GREMLIN Database
DUF4573 - Domain of unknown function (DUF4573)
PFAM: PF15140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 174 (161)
Sequences: 565 (480)
Seq/√Len: 37.9
META: 0.558

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_G96_G2.5921.00
69_R105_E2.4601.00
39_E57_E2.3441.00
60_G96_G2.2871.00
93_E111_E2.1620.99
54_A72_E2.0980.99
87_Q105_E2.0590.99
111_E129_E1.9950.99
84_E120_E1.9940.99
96_G114_E1.9940.99
69_R87_Q1.9320.98
89_V107_V1.9200.98
51_K69_R1.9140.98
60_G78_G1.9000.98
53_V107_V1.8580.98
42_E96_G1.8320.98
75_D93_E1.8150.97
45_T99_E1.7860.97
66_E84_E1.7760.97
33_E51_K1.6480.95
99_E117_G1.6220.95
72_E90_G1.6030.95
77_V113_V1.5970.95
24_Q42_E1.5960.95
48_E66_E1.5920.94
60_G114_E1.5740.94
85_P103_P1.5640.94
102_E120_E1.5580.94
79_P97_P1.5470.94
84_E102_E1.5460.94
95_V131_V1.5430.94
55_P91_P1.5380.93
45_T63_A1.5350.93
81_E99_E1.5080.93
114_E132_E1.4520.91
57_E111_E1.4440.91
37_P55_P1.4400.91
42_E60_G1.4400.91
96_G132_E1.4300.91
57_E75_D1.4230.90
50_V104_V1.4010.90
64_P118_P1.4000.90
107_V125_V1.3880.89
105_E123_Q1.3870.89
61_P115_P1.3720.89
87_Q123_Q1.3690.89
39_E93_E1.3640.88
69_R123_Q1.3640.88
57_E93_E1.3630.88
77_V95_V1.3630.88
58_P76_P1.3210.87
63_A81_E1.3030.86
78_G114_E1.3000.86
81_E117_G1.2890.85
68_V86_V1.2850.85
103_P121_P1.2810.85
58_P112_P1.2670.84
62_V80_V1.2580.84
27_G63_A1.2430.83
30_D66_E1.2280.82
100_P118_P1.2280.82
51_K123_Q1.2160.82
67_P103_P1.2160.82
76_P112_P1.2090.81
40_P58_P1.1990.81
72_E108_E1.1990.81
44_V80_V1.1850.80
90_G126_E1.1840.80
48_E102_E1.1760.80
91_P109_P1.1670.79
118_P136_P1.1650.79
142_Q160_E1.1600.79
73_P91_P1.1590.79
68_V104_V1.1520.78
52_P106_P1.1490.78
43_P61_P1.1330.77
48_E120_E1.1300.77
106_P124_P1.1090.75
59_V95_V1.0970.75
36_E90_G1.0820.74
74_V110_V1.0660.72
108_E126_E1.0650.72
55_P109_P1.0630.72
95_V113_V1.0600.72
51_K105_E1.0570.72
21_E57_E1.0410.71
52_P124_P1.0350.70
20_V38_V1.0310.70
39_E129_E1.0280.70
86_V104_V1.0240.69
61_P79_P1.0240.69
42_E114_E1.0100.68
54_A135_S1.0080.68
51_K87_Q1.0060.68
66_E102_E1.0020.68
70_P88_P0.9960.67
69_R78_G0.9950.67
47_V83_V0.9940.67
75_D111_E0.9880.67
49_P67_P0.9790.66
98_V116_V0.9750.65
25_P43_P0.9750.65
97_P115_P0.9720.65
64_P100_P0.9660.65
71_V125_V0.9650.65
78_G132_E0.9610.64
51_K78_G0.9420.63
33_E69_R0.9400.63
26_V44_V0.9310.62
104_V122_V0.9280.62
73_P109_P0.9250.61
80_V98_V0.9230.61
53_V71_V0.9200.61
64_P91_P0.9170.61
71_V89_V0.9050.60
30_D48_E0.9020.59
49_P103_P0.8970.59
46_P64_P0.8910.58
44_V98_V0.8820.58
89_V125_V0.8810.58
92_V110_V0.8790.57
55_P73_P0.8760.57
43_P97_P0.8740.57
61_P97_P0.8720.57
68_V95_V0.8690.56
74_V92_V0.8680.56
39_E75_D0.8610.56
85_P121_P0.8610.56
45_T81_E0.8590.56
50_V86_V0.8470.55
79_P115_P0.8460.54
65_V83_V0.8390.54
80_V134_V0.8390.54
32_V50_V0.8390.54
76_P94_P0.8260.53
46_P100_P0.8220.52
25_P79_P0.8190.52
33_E105_E0.8120.51
24_Q60_G0.8110.51
75_D129_E0.8110.51
110_V128_V0.8100.51
46_P73_P0.8090.51
101_V119_V0.8040.51
18_E36_E0.8000.50
50_V68_V0.7940.50
82_P100_P0.7920.50
57_E120_E0.7820.49
108_E142_Q0.7810.49
100_P136_P0.7770.48
90_G117_G0.7760.48
63_A99_E0.7720.48
82_P118_P0.7630.47
36_E99_E0.7620.47
49_P85_P0.7550.46
21_E39_E0.7500.46
27_G45_T0.7440.45
60_G87_Q0.7440.45
36_E126_E0.7330.44
33_E87_Q0.7270.44
75_D102_E0.7260.44
38_V128_V0.7250.44
19_P55_P0.7230.44
28_P91_P0.7220.43
88_P124_P0.7130.43
45_T117_G0.7030.42
52_P70_P0.7030.42
12_D111_E0.7010.42
63_A117_G0.6980.41
34_P52_P0.6960.41
64_P109_P0.6930.41
12_D30_D0.6820.40
44_V62_V0.6810.40
18_E108_E0.6770.40
41_V77_V0.6760.39
113_V131_V0.6750.39
70_P97_P0.6730.39
37_P91_P0.6710.39
44_V116_V0.6700.39
41_V59_V0.6670.39
93_E120_E0.6670.39
93_E129_E0.6660.39
70_P106_P0.6620.38
123_Q139_E0.6620.38
64_P82_P0.6580.38
126_E142_Q0.6580.38
57_E129_E0.6580.38
24_Q51_K0.6560.38
109_P127_P0.6550.38
88_P106_P0.6540.38
43_P133_P0.6540.38
54_A90_G0.6490.37
86_V122_V0.6470.37
73_P100_P0.6420.37
42_E78_G0.6330.36
91_P127_P0.6310.36
47_V65_V0.6270.35
33_E78_G0.6220.35
28_P82_P0.6210.35
90_G135_S0.6120.34
94_P112_P0.6110.34
66_E129_E0.6090.34
40_P94_P0.6080.34
33_E96_G0.6060.34
38_V74_V0.6000.33
36_E108_E0.5920.33
46_P109_P0.5860.32
48_E154_E0.5850.32
59_V77_V0.5820.32
47_V74_V0.5740.31
60_G123_Q0.5740.31
50_V131_V0.5740.31
117_G135_S0.5690.31
57_E63_A0.5690.31
54_A126_E0.5660.31
68_V122_V0.5660.31
51_K148_E0.5650.31
27_G81_E0.5620.30
81_E135_S0.5600.30
105_E132_E0.5570.30
28_P46_P0.5510.29
49_P112_P0.5480.29
96_G148_E0.5460.29
71_V107_V0.5430.29
32_V86_V0.5430.29
53_V89_V0.5430.29
44_V89_V0.5320.28
39_E84_E0.5290.28
67_P121_P0.5290.28
46_P118_P0.5270.28
69_R139_E0.5270.28
92_V128_V0.5260.28
45_T108_E0.5240.27
27_G135_S0.5230.27
90_G108_E0.5220.27
62_V98_V0.5210.27
22_P76_P0.5210.27
60_G132_E0.5210.27
31_P67_P0.5160.27
124_P140_P0.5120.27
48_E75_D0.5070.26
88_P140_P0.5060.26
87_Q99_E0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lcmA 1 0.1379 1.2 0.942 Contact Map
1mskA 1 0.3678 0.6 0.953 Contact Map
3bulA 1 0.3333 0.6 0.953 Contact Map
2lu2A 1 0.4655 0.5 0.954 Contact Map
3b23C 1 0.0172 0.4 0.958 Contact Map
4ggdC 1 0.046 0.4 0.958 Contact Map
4x2uA 1 0.3621 0.3 0.963 Contact Map
2jrhA 1 0.2471 0.3 0.963 Contact Map
4ujqF 1 0.4483 0.3 0.964 Contact Map
4ep8C 3 0.3851 0.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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