GREMLIN Database
THEG - Testicular haploid expressed repeat
PFAM: PF14912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (57)
Sequences: 827 (583)
Seq/√Len: 77.2
META: 0.164

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V41_A3.0751.00
3_V7_A2.6671.00
37_V42_L2.4341.00
4_S7_A2.2371.00
39_P42_L2.1471.00
4_S8_L2.1111.00
52_E55_K2.0421.00
26_H30_Q1.7581.00
14_P18_E1.7511.00
41_A44_A1.6271.00
29_Y33_R1.6101.00
39_P43_K1.6051.00
38_S42_L1.5030.99
25_R33_R1.5010.99
44_A47_S1.4670.99
15_R18_E1.3340.98
2_P57_K1.3200.98
22_P25_R1.3030.98
10_A13_S1.2730.98
5_R8_L1.2320.97
13_S16_I1.2300.97
48_P52_E1.2020.97
46_P51_L1.1600.96
28_I33_R1.1350.95
38_S41_A1.0970.94
5_R9_K1.0910.94
12_A17_L1.0810.94
46_P55_K1.0230.92
23_K26_H1.0210.92
10_A18_E1.0080.91
41_A47_S1.0070.91
1_W12_A1.0070.91
13_S17_L1.0040.91
14_P17_L0.9650.89
45_V52_E0.9580.89
41_A54_A0.9450.88
15_R49_R0.9430.88
40_A47_S0.8850.85
42_L45_V0.8820.85
30_Q33_R0.8810.85
36_K45_V0.8540.83
46_P50_I0.8400.82
40_A44_A0.8240.81
25_R32_N0.8140.80
53_L56_P0.7900.78
17_L27_P0.7850.77
22_P55_K0.7740.76
40_A45_V0.7670.76
37_V43_K0.7600.75
25_R29_Y0.7540.74
10_A16_I0.7460.74
25_R35_V0.7160.70
19_L55_K0.7000.69
12_A16_I0.6950.68
20_A48_P0.6760.66
17_L51_L0.6750.66
6_A11_K0.6710.65
20_A47_S0.6650.65
16_I24_V0.6620.64
23_K29_Y0.6590.64
3_V31_P0.6370.61
23_K51_L0.6280.60
43_K47_S0.6270.60
2_P5_R0.6170.59
26_H35_V0.6170.59
6_A9_K0.6100.58
44_A50_I0.6080.58
37_V40_A0.6000.57
42_L57_K0.5990.57
2_P6_A0.5800.54
20_A36_K0.5700.53
48_P51_L0.5620.52
38_S48_P0.5610.52
42_L48_P0.5580.52
40_A46_P0.5460.50
26_H33_R0.5390.49
4_S9_K0.5390.49
45_V51_L0.5370.49
37_V47_S0.5340.49
11_K40_A0.5260.48
17_L48_P0.5240.47
16_I28_I0.5130.46
8_L27_P0.5100.45
36_K43_K0.5040.45
20_A43_K0.5010.44
36_K40_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wx1A 2 0.3509 3.4 0.863 Contact Map
4oo3A 1 0.4211 2 0.877 Contact Map
4kqiA 2 0.5439 1.6 0.885 Contact Map
4hdrB 1 0.5439 1.5 0.887 Contact Map
3mcxA 1 0.3333 1.2 0.893 Contact Map
1eswA 1 0.4561 1.1 0.894 Contact Map
1ksiA 2 0.6667 1.1 0.894 Contact Map
3syjA 2 0.1053 1.1 0.895 Contact Map
2r7dA 1 0.3333 0.9 0.9 Contact Map
1spuA 2 0.5263 0.9 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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