GREMLIN Database
DUF4494 - Domain of unknown function (DUF4494)
PFAM: PF14902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 1942 (1230)
Seq/√Len: 104.7
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_K113_E3.8681.00
77_A112_L3.6031.00
80_S95_A2.6321.00
29_L33_E2.4941.00
109_Y128_I2.4821.00
4_C38_I2.3701.00
59_N97_Y2.2301.00
3_E56_K2.0991.00
114_E117_K2.0231.00
106_K109_Y1.9991.00
64_F115_G1.9761.00
60_Y99_L1.9621.00
80_S126_A1.9361.00
32_T36_A1.9151.00
39_I50_F1.9001.00
105_L109_Y1.9001.00
106_K110_K1.8911.00
65_F74_W1.8691.00
46_I50_F1.8151.00
79_V98_M1.8131.00
11_T17_Q1.8111.00
77_A128_I1.8041.00
7_K21_T1.7761.00
76_K97_Y1.6301.00
31_F55_I1.6221.00
76_K129_T1.6011.00
40_E43_S1.5901.00
78_K95_A1.5571.00
9_E17_Q1.5531.00
73_R130_E1.5511.00
107_E111_N1.5301.00
26_V38_I1.5211.00
124_E130_E1.5211.00
66_S111_N1.4971.00
53_T57_R1.4961.00
102_A107_E1.4611.00
9_E19_K1.4431.00
5_K54_D1.4251.00
84_L89_G1.4201.00
12_M16_K1.4201.00
12_M18_K1.4161.00
109_Y125_I1.4111.00
93_K124_E1.3931.00
72_D103_S1.3460.99
51_E57_R1.3250.99
82_I91_E1.2820.99
39_I43_S1.2710.99
31_F57_R1.2640.99
66_S71_G1.2590.99
100_V111_N1.2530.99
4_C55_I1.2440.99
65_F101_Q1.2360.99
28_A34_A1.2290.99
103_S107_E1.2190.99
41_E137_F1.2130.99
65_F138_P1.2090.99
36_A40_E1.1930.99
68_D71_G1.1830.99
10_K22_E1.1530.98
71_G107_E1.1460.98
1_W4_C1.1440.98
79_V116_M1.1410.98
7_K19_K1.1380.98
3_E23_P1.1090.98
115_G118_G1.0910.98
1_W136_V1.0850.98
100_V112_L1.0780.97
67_E70_N1.0740.97
118_G122_D1.0620.97
78_K97_Y1.0480.97
110_K113_E1.0470.97
109_Y113_E1.0250.97
105_L128_I1.0140.96
12_M17_Q1.0140.96
23_P132_P0.9990.96
5_K23_P0.9980.96
107_E110_K0.9860.96
80_S93_K0.9830.96
63_I99_L0.9800.96
52_V55_I0.9750.95
112_L116_M0.9620.95
36_A39_I0.9550.95
74_W99_L0.9470.95
54_D57_R0.9400.94
113_E123_Y0.9380.94
75_Y103_S0.9300.94
85_D88_S0.9290.94
95_A126_A0.9230.94
61_S96_V0.9210.94
126_A130_E0.9150.94
119_T122_D0.9100.93
126_A132_P0.9040.93
83_T94_T0.8920.93
3_E58_A0.8900.93
81_F94_T0.8750.92
71_G101_Q0.8740.92
42_M46_I0.8650.92
105_L125_I0.8590.91
6_V42_M0.8160.89
65_F136_V0.8140.89
31_F52_V0.8010.88
99_L133_I0.7970.88
27_D33_E0.7930.88
38_I42_M0.7920.87
109_Y126_A0.7880.87
74_W101_Q0.7830.87
41_E44_P0.7820.87
102_A111_N0.7810.87
31_F54_D0.7640.86
79_V112_L0.7580.85
81_F96_V0.7530.85
6_V46_I0.7480.84
22_E134_M0.7470.84
23_P133_I0.7470.84
98_M112_L0.7400.84
31_F35_E0.7310.83
2_F57_R0.7260.83
117_K121_A0.7210.82
60_Y63_I0.7210.82
5_K21_T0.7000.80
98_M115_G0.7000.80
19_K51_E0.6910.79
75_Y133_I0.6900.79
27_D37_R0.6890.79
102_A108_A0.6850.79
63_I104_D0.6850.79
8_Y46_I0.6840.79
4_C26_V0.6820.78
6_V38_I0.6810.78
82_I122_D0.6790.78
8_Y22_E0.6790.78
38_I52_V0.6670.77
110_K114_E0.6660.77
9_E12_M0.6650.77
71_G103_S0.6620.76
42_M137_F0.6550.76
16_K43_S0.6530.75
7_K74_W0.6520.75
111_N115_G0.6490.75
33_E37_R0.6480.75
31_F56_K0.6480.75
4_C34_A0.6440.74
125_I128_I0.6430.74
107_E113_E0.6420.74
58_A76_K0.6410.74
27_D30_S0.6390.74
14_N18_K0.6390.74
109_Y132_P0.6370.74
116_M119_T0.6350.73
111_N114_E0.6280.73
7_K53_T0.6240.72
93_K126_A0.6200.72
57_R109_Y0.6190.71
51_E54_D0.6190.71
73_R103_S0.6130.71
41_E75_Y0.6120.71
25_L98_M0.6090.70
77_A100_V0.6050.70
5_K132_P0.6050.70
68_D111_N0.6000.69
67_E71_G0.5950.68
12_M15_G0.5950.68
101_Q135_D0.5910.68
119_T123_Y0.5900.68
1_W27_D0.5880.68
113_E125_I0.5850.67
78_K126_A0.5800.67
46_I49_E0.5800.67
66_S101_Q0.5790.66
72_D101_Q0.5760.66
77_A105_L0.5740.66
70_N103_S0.5690.65
73_R124_E0.5650.65
43_S47_S0.5650.65
11_T16_K0.5640.64
3_E73_R0.5640.64
112_L115_G0.5590.64
30_S36_A0.5580.64
2_F31_F0.5510.63
83_T86_E0.5480.62
66_S103_S0.5470.62
90_K114_E0.5400.61
97_Y126_A0.5400.61
29_L36_A0.5370.61
4_C42_M0.5360.60
6_V48_G0.5360.60
44_P61_S0.5330.60
25_L63_I0.5330.60
115_G120_M0.5310.60
24_Y135_D0.5310.60
32_T55_I0.5290.60
42_M45_Y0.5280.59
116_M122_D0.5250.59
29_L37_R0.5210.58
2_F54_D0.5200.58
98_M116_M0.5200.58
89_G94_T0.5190.58
2_F6_V0.5190.58
48_G52_V0.5080.56
80_S129_T0.5070.56
10_K20_V0.5060.56
34_A55_I0.5040.56
62_E84_L0.5010.55
27_D91_E0.5010.55
38_I50_F0.5010.55
29_L120_M0.5000.55
58_A61_S0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ieqA 3 0.2878 3.3 0.941 Contact Map
2pjpA 1 0.705 2.5 0.945 Contact Map
2mamA 1 0.2878 2.4 0.945 Contact Map
2g3rA 2 0.6906 1.9 0.948 Contact Map
1cvrA 1 0.3885 1.8 0.949 Contact Map
1wdgA 3 0.259 1.7 0.95 Contact Map
2k0mA 1 0.3669 1.6 0.951 Contact Map
4lh9A 4 0.2878 1.5 0.951 Contact Map
1yobA 1 0.3381 1.5 0.951 Contact Map
2cozA 1 0.2878 1.4 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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