GREMLIN Database
DUF4492 - Domain of unknown function (DUF4492)
PFAM: PF14899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (62)
Sequences: 2465 (1444)
Seq/√Len: 183.3
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_F33_A3.7281.00
4_F8_Y2.8181.00
3_I6_F2.5591.00
50_T53_E2.5211.00
16_L20_L2.2591.00
45_K54_R2.0641.00
8_Y12_R1.8451.00
59_L63_T1.7961.00
5_R9_D1.7591.00
25_L29_F1.6521.00
33_A37_L1.6211.00
15_T20_L1.4361.00
28_L31_M1.3301.00
55_S58_V1.3181.00
35_L38_F1.2831.00
36_K42_D1.2421.00
52_E56_E1.2261.00
43_F46_T1.2131.00
51_D54_R1.2081.00
10_G21_W1.1951.00
5_R8_Y1.1891.00
47_N57_Y1.1301.00
57_Y61_Q1.1181.00
43_F57_Y1.1131.00
48_F51_D1.0981.00
48_F57_Y1.0971.00
43_F47_N1.0941.00
14_M17_G1.0741.00
35_L40_F1.0691.00
14_M21_W1.0691.00
16_L19_T1.0571.00
42_D45_K1.0491.00
55_S59_L1.0291.00
22_L26_I1.0080.99
42_D47_N1.0060.99
17_G21_W0.9990.99
47_N54_R0.9840.99
9_D13_N0.9690.99
31_M35_L0.9600.99
56_E60_E0.9330.99
48_F54_R0.9290.99
2_R5_R0.9220.99
44_L58_V0.8980.99
22_L25_L0.8940.99
44_L57_Y0.8780.99
51_D55_S0.8590.98
15_T22_L0.8520.98
21_W24_I0.8370.98
34_I37_L0.8320.98
41_P45_K0.8210.98
34_I40_F0.8090.97
33_A38_F0.8040.97
30_I34_I0.7840.97
29_F34_I0.7610.96
53_E56_E0.7520.96
6_F9_D0.7460.96
50_T54_R0.7350.96
41_P54_R0.7280.95
7_Y11_F0.7230.95
41_P46_T0.7130.95
28_L32_F0.7020.94
43_F61_Q0.7020.94
11_F24_I0.6880.94
19_T23_I0.6670.93
9_D12_R0.6650.93
36_K39_F0.6600.92
3_I24_I0.6580.92
32_F36_K0.6570.92
34_I38_F0.6510.92
35_L39_F0.6370.91
25_L28_L0.6260.90
6_F11_F0.6210.90
5_R13_N0.6140.89
49_D53_E0.6050.89
19_T22_L0.6040.88
46_T49_D0.6020.88
25_L38_F0.5890.87
14_M18_K0.5820.87
22_L59_L0.5810.86
11_F21_W0.5680.85
7_Y24_I0.5660.85
48_F53_E0.5660.85
49_D52_E0.5620.85
47_N59_L0.5550.84
2_R46_T0.5480.83
55_S60_E0.5390.82
54_R59_L0.5340.82
5_R56_E0.5330.81
42_D46_T0.5060.78
11_F14_M0.5060.78
13_N16_L0.5040.78
26_I61_Q0.5040.78
29_F38_F0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3skqA 1 0.0635 14.7 0.89 Contact Map
3mk7C 2 0.7619 2.9 0.922 Contact Map
3j7ys 1 0.1905 2.6 0.923 Contact Map
2zw3A 5 0.8413 2 0.927 Contact Map
2cvcA 1 0.127 1.8 0.929 Contact Map
3zyzA 1 0.381 1.7 0.93 Contact Map
3echC 1 0.1905 1.6 0.932 Contact Map
4b2zA 1 0.7143 1.5 0.933 Contact Map
1uqtA 2 0.8413 1.4 0.934 Contact Map
1srvA 1 0.4444 1.3 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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