GREMLIN Database
DUF4491 - Domain of unknown function (DUF4491)
PFAM: PF14898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (92)
Sequences: 2137 (1406)
Seq/√Len: 146.6
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K82_E3.4821.00
31_T78_E3.3301.00
25_G33_C2.9691.00
10_A59_L2.8641.00
44_L63_F2.6811.00
40_L67_L2.0831.00
18_F67_L2.0581.00
51_I60_L2.0521.00
31_T75_F2.0511.00
72_G76_E2.0311.00
29_F33_C1.9311.00
89_N92_R1.7561.00
18_F70_S1.7501.00
28_Y89_N1.7161.00
78_E82_E1.6911.00
38_L42_I1.6791.00
11_T62_V1.6491.00
8_G65_F1.6311.00
25_G29_F1.6121.00
53_N56_L1.5561.00
34_W75_F1.5321.00
45_I64_G1.5051.00
51_I56_L1.4611.00
47_A60_L1.3981.00
45_I68_L1.3621.00
63_F67_L1.3431.00
24_K28_Y1.3421.00
7_I58_A1.3361.00
2_F6_I1.3041.00
25_G37_F1.2721.00
44_L67_L1.2411.00
75_F78_E1.2321.00
82_E88_K1.2171.00
33_C36_V1.2161.00
18_F21_I1.1481.00
67_L70_S1.1230.99
7_I55_I1.1100.99
14_I63_F1.0970.99
46_A50_F1.0830.99
18_F63_F1.0830.99
64_G68_L1.0660.99
54_V58_A1.0650.99
3_T54_V1.0590.99
35_W74_L1.0510.99
77_Q80_R1.0380.99
6_I55_I1.0340.99
44_L47_A1.0280.99
25_G70_S1.0160.99
73_E77_Q0.9950.99
38_L71_I0.9900.99
14_I76_E0.9870.99
57_S61_G0.9810.98
17_L21_I0.9760.98
79_K83_K0.9710.98
29_F36_V0.9480.98
43_A47_A0.9090.97
3_T55_I0.9050.97
18_F66_S0.8950.97
11_T15_I0.8810.97
44_L60_L0.8750.97
21_I70_S0.8730.97
25_G74_L0.8720.97
72_G79_K0.8660.97
34_W38_L0.8550.96
47_A50_F0.8240.96
8_G68_L0.8160.95
23_I86_F0.8090.95
19_H22_V0.8060.95
3_T6_I0.8040.95
76_E79_K0.7990.95
21_I37_F0.7820.94
6_I9_L0.7760.94
21_I58_A0.7670.93
23_I70_S0.7670.93
48_S58_A0.7540.93
26_E78_E0.7380.92
16_G20_P0.7310.92
46_A54_V0.7230.91
16_G19_H0.7170.91
4_G61_G0.7150.91
44_L64_G0.7050.90
26_E34_W0.7010.90
69_W73_E0.6960.90
56_L59_L0.6910.89
78_E88_K0.6810.89
73_E80_R0.6800.89
42_I46_A0.6750.88
33_C74_L0.6700.88
10_A14_I0.6640.87
9_L54_V0.6610.87
26_E31_T0.6610.87
17_L42_I0.6590.87
13_L17_L0.6550.87
21_I25_G0.6550.87
12_F20_P0.6500.86
17_L20_P0.6460.86
10_A55_I0.6460.86
23_I66_S0.6430.86
7_I62_V0.6400.85
24_K30_G0.6350.85
30_G34_W0.6290.84
81_V85_W0.6240.84
43_A50_F0.6230.84
52_E57_S0.6220.84
27_Y37_F0.6190.83
5_L48_S0.6130.83
39_L43_A0.6030.82
22_V70_S0.6020.82
16_G30_G0.5920.81
16_G22_V0.5920.81
22_V66_S0.5920.81
21_I67_L0.5860.80
47_A51_I0.5810.79
18_F40_L0.5750.79
88_K92_R0.5750.79
43_A46_A0.5720.78
11_T54_V0.5640.77
65_F68_L0.5640.77
63_F66_S0.5610.77
71_I86_F0.5570.77
27_Y48_S0.5540.76
11_T14_I0.5450.75
25_G30_G0.5440.75
4_G57_S0.5360.74
72_G75_F0.5320.73
1_N4_G0.5280.73
64_G69_W0.5260.72
45_I58_A0.5240.72
27_Y84_G0.5220.72
81_V84_G0.5180.71
10_A13_L0.5170.71
59_L63_F0.5140.71
35_W64_G0.5110.70
40_L44_L0.5100.70
1_N52_E0.5080.70
83_K86_F0.5070.70
12_F15_I0.5030.69
23_I30_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wjnM 1 0.8913 12.1 0.927 Contact Map
1fftA 1 0.9674 6.6 0.935 Contact Map
1eysL 1 0.8587 6.4 0.936 Contact Map
3tx3A 2 0.8478 6.3 0.936 Contact Map
3dh4A 3 0.913 5.7 0.937 Contact Map
3l1lA 2 0.913 5.7 0.937 Contact Map
4wgvA 2 0.9239 5.6 0.937 Contact Map
2gsmA 1 0.9565 5.4 0.938 Contact Map
2yevA 1 0.9348 5 0.939 Contact Map
1m56C 2 0.75 4.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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