GREMLIN Database
EpsG - EpsG family
PFAM: PF14897 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 326 (315)
Sequences: 8918 (8302)
Seq/√Len: 467.8
META: 0.755

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_G143_L4.2721.00
130_K133_K3.7681.00
49_G144_F2.8511.00
55_K59_S2.8481.00
142_S149_L2.8431.00
77_F81_K2.8301.00
119_F151_F2.8201.00
29_L33_E2.6081.00
57_L70_I2.5701.00
153_P156_F2.5471.00
64_Y68_F2.5281.00
53_L71_I2.4861.00
78_L121_L2.4801.00
19_Y25_Y2.4601.00
134_F138_I2.4191.00
141_A148_A2.3881.00
125_Y137_L2.3671.00
85_K124_K2.3301.00
138_I142_S2.2861.00
54_N67_F2.2671.00
81_K121_L2.2601.00
115_A148_A2.2161.00
78_L82_F2.1721.00
45_G48_P2.1641.00
23_T108_N2.1591.00
47_E111_R2.0591.00
65_Q68_F2.0531.00
16_G69_F2.0151.00
142_S146_K1.9911.00
242_K246_N1.9851.00
118_I144_F1.9751.00
62_L66_V1.9721.00
50_F54_N1.9651.00
71_I114_L1.9601.00
55_K58_K1.9551.00
87_S93_S1.9551.00
81_K85_K1.9461.00
47_E146_K1.9341.00
12_I16_G1.8911.00
36_S58_K1.8891.00
8_F12_I1.8811.00
74_I78_L1.8761.00
13_L17_L1.8591.00
82_F120_L1.8441.00
78_L117_A1.8431.00
31_I46_F1.8271.00
75_F106_S1.7831.00
124_K128_K1.7691.00
131_L135_L1.7591.00
29_L64_Y1.7351.00
147_S271_Y1.7141.00
79_L106_S1.6761.00
57_L66_V1.6701.00
148_A271_Y1.6691.00
123_L275_F1.6211.00
112_Q271_Y1.6201.00
12_I73_L1.6041.00
122_A134_F1.5981.00
278_I282_Y1.5771.00
105_V109_G1.5691.00
278_I281_P1.5661.00
114_L144_F1.5651.00
32_F57_L1.5631.00
119_F148_A1.5501.00
8_F80_Y1.5341.00
12_I76_I1.5301.00
73_L77_F1.5231.00
118_I137_L1.5191.00
85_K128_K1.5161.00
122_A137_L1.5151.00
15_A72_A1.5101.00
83_I93_S1.4931.00
57_L62_L1.4561.00
97_F106_S1.4431.00
126_L134_F1.4141.00
131_L155_Y1.4031.00
82_F86_Y1.3991.00
125_Y133_K1.3901.00
20_G25_Y1.3781.00
216_G220_L1.3571.00
99_S103_F1.3511.00
80_Y84_K1.3501.00
68_F72_A1.3341.00
81_K84_K1.3331.00
115_A141_A1.3121.00
18_R22_G1.3051.00
25_Y68_F1.3051.00
48_P143_L1.2921.00
67_F71_I1.2891.00
78_L118_I1.2851.00
256_L260_F1.2841.00
22_G108_N1.2811.00
75_F117_A1.2771.00
128_K133_K1.2771.00
82_F124_K1.2711.00
231_K234_K1.2651.00
79_L117_A1.2631.00
282_Y285_S1.2601.00
308_F311_S1.2581.00
15_A107_M1.2571.00
23_T109_G1.2561.00
50_F110_I1.2541.00
228_L232_I1.2531.00
18_R25_Y1.2501.00
106_S113_G1.2421.00
30_E34_N1.2121.00
61_G66_V1.2091.00
118_I141_A1.1931.00
72_A76_I1.1871.00
290_K294_K1.1861.00
63_N66_V1.1831.00
117_A121_L1.1811.00
289_K293_R1.1641.00
289_K292_K1.1611.00
230_K233_K1.1581.00
112_Q270_L1.1561.00
100_L104_F1.1541.00
140_L143_L1.1451.00
139_L143_L1.1451.00
288_F291_K1.1391.00
57_L67_F1.1321.00
174_I177_L1.1291.00
74_I114_L1.1291.00
248_Y276_Q1.1261.00
230_K234_K1.1221.00
105_V113_G1.1171.00
48_P146_K1.1151.00
68_F110_I1.1051.00
86_Y124_K1.1041.00
52_L56_L1.0991.00
75_F78_L1.0981.00
197_K200_S1.0931.00
83_I277_I1.0911.00
243_L247_L1.0871.00
122_A141_A1.0861.00
233_K236_K1.0801.00
129_K132_I1.0741.00
126_L155_Y1.0701.00
32_F61_G1.0621.00
112_Q147_S1.0541.00
51_Y55_K1.0531.00
281_P285_S1.0521.00
82_F117_A1.0451.00
79_L83_I1.0441.00
82_F121_L1.0431.00
140_L144_F1.0381.00
50_F71_I1.0351.00
86_Y127_L1.0171.00
121_L124_K1.0171.00
308_F312_L1.0131.00
65_Q69_F1.0111.00
109_G112_Q1.0101.00
288_F292_K1.0071.00
133_K137_L1.0051.00
160_K163_K1.0041.00
306_L310_Y1.0031.00
40_F55_K1.0021.00
26_Y30_E1.0001.00
32_F36_S0.9971.00
214_R219_L0.9951.00
309_F312_L0.9921.00
307_F311_S0.9911.00
20_G26_Y0.9891.00
100_L103_F0.9871.00
216_G219_L0.9861.00
95_L99_S0.9841.00
106_S109_G0.9801.00
122_A138_I0.9761.00
32_F54_N0.9761.00
84_K88_K0.9711.00
126_L131_L0.9691.00
27_N30_E0.9641.00
75_F114_L0.9611.00
122_A125_Y0.9601.00
75_F79_L0.9601.00
177_L181_L0.9571.00
31_I54_N0.9561.00
12_I69_F0.9521.00
109_G113_G0.9521.00
4_L80_Y0.9431.00
312_L315_F0.9381.00
197_K201_Y0.9371.00
217_L221_L0.9351.00
304_Y308_F0.9311.00
110_I113_G0.9281.00
32_F67_F0.9281.00
219_L223_I0.9281.00
103_F107_M0.9271.00
282_Y286_K0.9261.00
269_A272_F0.9231.00
256_L259_S0.9221.00
290_K293_R0.9201.00
137_L140_L0.9131.00
109_G270_L0.9121.00
277_I281_P0.9111.00
29_L68_F0.9111.00
72_A75_F0.9071.00
71_I110_I0.9041.00
142_S148_A0.9031.00
99_S102_F0.9031.00
25_Y64_Y0.9031.00
58_K62_L0.9011.00
80_Y94_L0.8991.00
78_L114_L0.8961.00
76_I80_Y0.8881.00
32_F62_L0.8881.00
166_L170_L0.8871.00
105_V270_L0.8831.00
234_K237_K0.8781.00
15_A102_F0.8771.00
178_L181_L0.8761.00
25_Y29_L0.8741.00
307_F310_Y0.8741.00
93_S281_P0.8741.00
214_R221_L0.8711.00
76_I106_S0.8701.00
27_N109_G0.8671.00
15_A106_S0.8661.00
175_L178_L0.8651.00
14_F18_R0.8631.00
50_F111_R0.8621.00
229_F232_I0.8621.00
54_N58_K0.8601.00
118_I121_L0.8591.00
136_L140_L0.8571.00
279_L282_Y0.8561.00
214_R217_L0.8541.00
111_R145_H0.8521.00
131_L134_F0.8471.00
66_V69_F0.8461.00
48_P51_Y0.8451.00
57_L61_G0.8441.00
119_F141_A0.8401.00
311_S315_F0.8391.00
112_Q116_I0.8381.00
201_Y205_E0.8361.00
115_A271_Y0.8341.00
216_G221_L0.8331.00
46_F51_Y0.8311.00
218_L221_L0.8301.00
49_G71_I0.8281.00
165_K169_L0.8251.00
81_K124_K0.8251.00
210_G213_I0.8251.00
303_L307_F0.8241.00
228_L231_K0.8231.00
180_L183_L0.8211.00
19_Y65_Q0.8211.00
166_L169_L0.8161.00
198_Y202_L0.8161.00
30_E33_E0.8151.00
93_S96_L0.8151.00
164_K179_L0.8141.00
309_F313_L0.8121.00
75_F113_G0.8091.00
183_L186_S0.8081.00
129_K133_K0.8071.00
119_F134_F0.7951.00
218_L222_F0.7931.00
48_P52_L0.7901.00
248_Y252_L0.7901.00
53_L57_L0.7901.00
122_A126_L0.7821.00
168_L172_I0.7821.00
251_G255_L0.7771.00
204_S207_S0.7771.00
5_L8_F0.7751.00
53_L67_F0.7731.00
134_F155_Y0.7731.00
71_I75_F0.7681.00
125_Y134_F0.7671.00
235_K238_K0.7651.00
143_L146_K0.7631.00
274_I277_I0.7611.00
32_F64_Y0.7591.00
297_L305_F0.7581.00
19_Y22_G0.7571.00
247_L251_G0.7511.00
119_F138_I0.7501.00
19_Y29_L0.7461.00
125_Y130_K0.7441.00
275_F279_L0.7431.00
138_I151_F0.7421.00
51_Y54_N0.7411.00
22_G25_Y0.7411.00
10_L14_F0.7371.00
3_L7_L0.7331.00
165_K168_L0.7331.00
123_L127_L0.7321.00
113_G117_A0.7291.00
269_A273_L0.7281.00
160_K164_K0.7281.00
215_V222_F0.7271.00
21_V107_M0.7261.00
291_K294_K0.7241.00
252_L256_L0.7241.00
149_L153_P0.7221.00
129_K159_K0.7191.00
251_G273_L0.7161.00
153_P158_A0.7151.00
16_G72_A0.7111.00
216_G222_F0.7081.00
78_L81_K0.7071.00
305_F309_F0.7051.00
163_K166_L0.7041.00
128_K132_I0.7031.00
116_I271_Y0.7031.00
141_A144_F0.7001.00
253_L256_L0.6981.00
52_L55_K0.6971.00
135_L139_L0.6951.00
124_K127_L0.6941.00
33_E64_Y0.6931.00
25_Y107_M0.6931.00
18_R72_A0.6911.00
104_F108_N0.6891.00
308_F314_N0.6871.00
155_Y158_A0.6851.00
138_I141_A0.6851.00
232_I235_K0.6841.00
177_L180_L0.6811.00
302_L306_L0.6771.00
56_L60_L0.6761.00
8_F76_I0.6751.00
105_V112_Q0.6711.00
124_K134_F0.6711.00
132_I136_L0.6691.00
230_K235_K0.6681.00
98_F102_F0.6671.00
135_L152_L0.6661.00
214_R218_L0.6641.00
298_L302_L0.6641.00
54_N57_L0.6611.00
175_L179_L0.6581.00
111_R146_K0.6561.00
179_L183_L0.6561.00
311_S316_G0.6551.00
18_R21_V0.6551.00
233_K237_K0.6551.00
76_I79_L0.6551.00
310_Y314_N0.6521.00
216_G230_K0.6511.00
84_K87_S0.6481.00
281_P284_L0.6471.00
303_L306_L0.6461.00
57_L60_L0.6451.00
185_L189_S0.6451.00
231_K235_K0.6431.00
225_F229_F0.6421.00
120_L274_I0.6421.00
221_L224_L0.6411.00
280_L283_L0.6361.00
15_A76_I0.6321.00
164_K168_L0.6310.99
227_L230_K0.6310.99
119_F122_A0.6290.99
121_L125_Y0.6270.99
98_F101_L0.6270.99
114_L118_I0.6270.99
84_K90_P0.6260.99
310_Y313_L0.6260.99
13_L16_G0.6250.99
119_F123_L0.6250.99
311_S314_N0.6230.99
167_L170_L0.6220.99
248_Y251_G0.6220.99
199_S203_E0.6200.99
49_G53_L0.6170.99
75_F82_F0.6170.99
18_R68_F0.6170.99
183_L187_L0.6140.99
297_L304_Y0.6100.99
12_I17_L0.6100.99
263_P266_D0.6090.99
151_F271_Y0.6060.99
165_K172_I0.6060.99
178_L182_S0.6050.99
148_A151_F0.6030.99
170_L174_I0.6030.99
171_L174_I0.6010.99
101_L104_F0.6010.99
314_N317_D0.6000.99
246_N253_L0.6000.99
54_N71_I0.5980.99
114_L117_A0.5980.99
35_I58_K0.5980.99
58_K61_G0.5980.99
203_E206_Y0.5960.99
301_I305_F0.5960.99
134_F151_F0.5950.99
220_L223_I0.5920.99
219_L222_F0.5900.99
249_L253_L0.5900.99
299_I303_L0.5890.99
154_L247_L0.5820.99
86_Y244_L0.5810.99
5_L9_L0.5790.99
251_G254_L0.5780.99
230_K236_K0.5770.99
303_L311_S0.5760.99
75_F97_F0.5760.99
174_I178_L0.5750.99
139_L142_S0.5740.99
278_I285_S0.5720.99
25_Y109_G0.5720.99
57_L64_Y0.5710.99
60_L66_V0.5700.99
258_F262_S0.5700.99
220_L224_L0.5680.99
104_F107_M0.5660.99
297_L312_L0.5660.99
119_F275_F0.5650.99
217_L220_L0.5650.99
100_L105_V0.5590.99
247_L275_F0.5560.99
87_S90_P0.5550.99
33_E36_S0.5510.99
244_L248_Y0.5490.99
26_Y29_L0.5480.99
154_L272_F0.5480.99
312_L316_G0.5470.99
206_Y209_G0.5470.99
209_G212_L0.5460.99
135_L155_Y0.5450.99
229_F233_K0.5440.99
108_N113_G0.5440.99
203_E207_S0.5430.98
83_I87_S0.5430.98
15_A18_R0.5420.98
10_L13_L0.5410.98
18_R108_N0.5390.98
35_I55_K0.5370.98
50_F144_F0.5360.98
300_L304_Y0.5360.98
127_L131_L0.5360.98
232_I236_K0.5360.98
50_F67_F0.5340.98
35_I38_G0.5340.98
79_L97_F0.5340.98
151_F154_L0.5330.98
161_K164_K0.5310.98
308_F313_L0.5310.98
279_L283_L0.5290.98
257_L260_F0.5270.98
112_Q148_A0.5270.98
82_F278_I0.5260.98
17_L25_Y0.5260.98
35_I39_S0.5250.98
129_K158_A0.5250.98
146_K197_K0.5240.98
153_P272_F0.5240.98
235_K239_E0.5240.98
272_F275_F0.5230.98
31_I34_N0.5230.98
301_I306_L0.5220.98
101_L105_V0.5220.98
165_K179_L0.5220.98
215_V218_L0.5210.98
46_F49_G0.5190.98
246_N254_L0.5190.98
266_D270_L0.5190.98
73_L76_I0.5170.98
96_L277_I0.5160.98
304_Y311_S0.5150.98
11_L15_A0.5130.98
304_Y307_F0.5120.98
20_G29_L0.5090.98
246_N250_I0.5040.98
32_F58_K0.5040.98
184_I188_L0.5020.98
156_F160_K0.5010.97
120_L275_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rceA 1 0.9172 3.8 0.946 Contact Map
2m7cA 1 0.0613 1 0.961 Contact Map
2l2tA 2 0.135 1 0.961 Contact Map
4gbfA 1 0.1718 1 0.961 Contact Map
2k3cA 1 0.0951 0.8 0.963 Contact Map
4w251 1 0.0828 0.6 0.967 Contact Map
1m56D 1 0.0583 0.5 0.968 Contact Map
3b5dA 2 0.2914 0.5 0.968 Contact Map
2jwaA 2 0.1288 0.5 0.968 Contact Map
2z73A 2 0.7975 0.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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