EpsG - PFAM28P - GREMLIN Contacts

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EpsG - EpsG family

PFAM:	PF14897	Sequences: KILLLLLFLLLILFAGLRYGVGTDYYNYLEIFENISSGSFSFSSGFEPGFYLLNKLLKSLGLNYQVFFFIIALIFIFLLYKFIKKYSKNPFLSLLLFFSLLFFFVSMNGIRQGLAIAIFLLALKYLLKKKLIKFLLLILLASLFHKSALIFLPLYFLAKKKLKKKLLLLLLILILLLLLLLSLILSLLSSLLPISEKYSSYLESEYSSGGGLIRVGLLLLLFILFLLLFKKIKKKKKKEKYKLLLNLYLIGLLLLLLFSFSSPIADRLALYFLIFQIILLPYLLSKIFKKKKRKLILLILILLYFLFFFYSLLNFGDSSGYLPYKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	326 (315)
Sequences:	8918 (8302)
Seq/√Len:	467.8
META:	0.755

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_G	143_L	4.272	1.00
130_K	133_K	3.768	1.00
49_G	144_F	2.851	1.00
55_K	59_S	2.848	1.00
142_S	149_L	2.843	1.00
77_F	81_K	2.830	1.00
119_F	151_F	2.820	1.00
29_L	33_E	2.608	1.00
57_L	70_I	2.570	1.00
153_P	156_F	2.547	1.00
64_Y	68_F	2.528	1.00
53_L	71_I	2.486	1.00
78_L	121_L	2.480	1.00
19_Y	25_Y	2.460	1.00
134_F	138_I	2.419	1.00
141_A	148_A	2.388	1.00
125_Y	137_L	2.367	1.00
85_K	124_K	2.330	1.00
138_I	142_S	2.286	1.00
54_N	67_F	2.267	1.00
81_K	121_L	2.260	1.00
115_A	148_A	2.216	1.00
78_L	82_F	2.172	1.00
45_G	48_P	2.164	1.00
23_T	108_N	2.159	1.00
47_E	111_R	2.059	1.00
65_Q	68_F	2.053	1.00
16_G	69_F	2.015	1.00
142_S	146_K	1.991	1.00
242_K	246_N	1.985	1.00
118_I	144_F	1.975	1.00
62_L	66_V	1.972	1.00
50_F	54_N	1.965	1.00
71_I	114_L	1.960	1.00
55_K	58_K	1.955	1.00
87_S	93_S	1.955	1.00
81_K	85_K	1.946	1.00
47_E	146_K	1.934	1.00
12_I	16_G	1.891	1.00
36_S	58_K	1.889	1.00
8_F	12_I	1.881	1.00
74_I	78_L	1.876	1.00
13_L	17_L	1.859	1.00
82_F	120_L	1.844	1.00
78_L	117_A	1.843	1.00
31_I	46_F	1.827	1.00
75_F	106_S	1.783	1.00
124_K	128_K	1.769	1.00
131_L	135_L	1.759	1.00
29_L	64_Y	1.735	1.00
147_S	271_Y	1.714	1.00
79_L	106_S	1.676	1.00
57_L	66_V	1.670	1.00
148_A	271_Y	1.669	1.00
123_L	275_F	1.621	1.00
112_Q	271_Y	1.620	1.00
12_I	73_L	1.604	1.00
122_A	134_F	1.598	1.00
278_I	282_Y	1.577	1.00
105_V	109_G	1.569	1.00
278_I	281_P	1.566	1.00
114_L	144_F	1.565	1.00
32_F	57_L	1.563	1.00
119_F	148_A	1.550	1.00
8_F	80_Y	1.534	1.00
12_I	76_I	1.530	1.00
73_L	77_F	1.523	1.00
118_I	137_L	1.519	1.00
85_K	128_K	1.516	1.00
122_A	137_L	1.515	1.00
15_A	72_A	1.510	1.00
83_I	93_S	1.493	1.00
57_L	62_L	1.456	1.00
97_F	106_S	1.443	1.00
126_L	134_F	1.414	1.00
131_L	155_Y	1.403	1.00
82_F	86_Y	1.399	1.00
125_Y	133_K	1.390	1.00
20_G	25_Y	1.378	1.00
216_G	220_L	1.357	1.00
99_S	103_F	1.351	1.00
80_Y	84_K	1.350	1.00
68_F	72_A	1.334	1.00
81_K	84_K	1.333	1.00
115_A	141_A	1.312	1.00
18_R	22_G	1.305	1.00
25_Y	68_F	1.305	1.00
48_P	143_L	1.292	1.00
67_F	71_I	1.289	1.00
78_L	118_I	1.285	1.00
256_L	260_F	1.284	1.00
22_G	108_N	1.281	1.00
75_F	117_A	1.277	1.00
128_K	133_K	1.277	1.00
82_F	124_K	1.271	1.00
231_K	234_K	1.265	1.00
79_L	117_A	1.263	1.00
282_Y	285_S	1.260	1.00
308_F	311_S	1.258	1.00
15_A	107_M	1.257	1.00
23_T	109_G	1.256	1.00
50_F	110_I	1.254	1.00
228_L	232_I	1.253	1.00
18_R	25_Y	1.250	1.00
106_S	113_G	1.242	1.00
30_E	34_N	1.212	1.00
61_G	66_V	1.209	1.00
118_I	141_A	1.193	1.00
72_A	76_I	1.187	1.00
290_K	294_K	1.186	1.00
63_N	66_V	1.183	1.00
117_A	121_L	1.181	1.00
289_K	293_R	1.164	1.00
289_K	292_K	1.161	1.00
230_K	233_K	1.158	1.00
112_Q	270_L	1.156	1.00
100_L	104_F	1.154	1.00
140_L	143_L	1.145	1.00
139_L	143_L	1.145	1.00
288_F	291_K	1.139	1.00
57_L	67_F	1.132	1.00
174_I	177_L	1.129	1.00
74_I	114_L	1.129	1.00
248_Y	276_Q	1.126	1.00
230_K	234_K	1.122	1.00
105_V	113_G	1.117	1.00
48_P	146_K	1.115	1.00
68_F	110_I	1.105	1.00
86_Y	124_K	1.104	1.00
52_L	56_L	1.099	1.00
75_F	78_L	1.098	1.00
197_K	200_S	1.093	1.00
83_I	277_I	1.091	1.00
243_L	247_L	1.087	1.00
122_A	141_A	1.086	1.00
233_K	236_K	1.080	1.00
129_K	132_I	1.074	1.00
126_L	155_Y	1.070	1.00
32_F	61_G	1.062	1.00
112_Q	147_S	1.054	1.00
51_Y	55_K	1.053	1.00
281_P	285_S	1.052	1.00
82_F	117_A	1.045	1.00
79_L	83_I	1.044	1.00
82_F	121_L	1.043	1.00
140_L	144_F	1.038	1.00
50_F	71_I	1.035	1.00
86_Y	127_L	1.017	1.00
121_L	124_K	1.017	1.00
308_F	312_L	1.013	1.00
65_Q	69_F	1.011	1.00
109_G	112_Q	1.010	1.00
288_F	292_K	1.007	1.00
133_K	137_L	1.005	1.00
160_K	163_K	1.004	1.00
306_L	310_Y	1.003	1.00
40_F	55_K	1.002	1.00
26_Y	30_E	1.000	1.00
32_F	36_S	0.997	1.00
214_R	219_L	0.995	1.00
309_F	312_L	0.992	1.00
307_F	311_S	0.991	1.00
20_G	26_Y	0.989	1.00
100_L	103_F	0.987	1.00
216_G	219_L	0.986	1.00
95_L	99_S	0.984	1.00
106_S	109_G	0.980	1.00
122_A	138_I	0.976	1.00
32_F	54_N	0.976	1.00
84_K	88_K	0.971	1.00
126_L	131_L	0.969	1.00
27_N	30_E	0.964	1.00
75_F	114_L	0.961	1.00
122_A	125_Y	0.960	1.00
75_F	79_L	0.960	1.00
177_L	181_L	0.957	1.00
31_I	54_N	0.956	1.00
12_I	69_F	0.952	1.00
109_G	113_G	0.952	1.00
4_L	80_Y	0.943	1.00
312_L	315_F	0.938	1.00
197_K	201_Y	0.937	1.00
217_L	221_L	0.935	1.00
304_Y	308_F	0.931	1.00
110_I	113_G	0.928	1.00
32_F	67_F	0.928	1.00
219_L	223_I	0.928	1.00
103_F	107_M	0.927	1.00
282_Y	286_K	0.926	1.00
269_A	272_F	0.923	1.00
256_L	259_S	0.922	1.00
290_K	293_R	0.920	1.00
137_L	140_L	0.913	1.00
109_G	270_L	0.912	1.00
277_I	281_P	0.911	1.00
29_L	68_F	0.911	1.00
72_A	75_F	0.907	1.00
71_I	110_I	0.904	1.00
142_S	148_A	0.903	1.00
99_S	102_F	0.903	1.00
25_Y	64_Y	0.903	1.00
58_K	62_L	0.901	1.00
80_Y	94_L	0.899	1.00
78_L	114_L	0.896	1.00
76_I	80_Y	0.888	1.00
32_F	62_L	0.888	1.00
166_L	170_L	0.887	1.00
105_V	270_L	0.883	1.00
234_K	237_K	0.878	1.00
15_A	102_F	0.877	1.00
178_L	181_L	0.876	1.00
25_Y	29_L	0.874	1.00
307_F	310_Y	0.874	1.00
93_S	281_P	0.874	1.00
214_R	221_L	0.871	1.00
76_I	106_S	0.870	1.00
27_N	109_G	0.867	1.00
15_A	106_S	0.866	1.00
175_L	178_L	0.865	1.00
14_F	18_R	0.863	1.00
50_F	111_R	0.862	1.00
229_F	232_I	0.862	1.00
54_N	58_K	0.860	1.00
118_I	121_L	0.859	1.00
136_L	140_L	0.857	1.00
279_L	282_Y	0.856	1.00
214_R	217_L	0.854	1.00
111_R	145_H	0.852	1.00
131_L	134_F	0.847	1.00
66_V	69_F	0.846	1.00
48_P	51_Y	0.845	1.00
57_L	61_G	0.844	1.00
119_F	141_A	0.840	1.00
311_S	315_F	0.839	1.00
112_Q	116_I	0.838	1.00
201_Y	205_E	0.836	1.00
115_A	271_Y	0.834	1.00
216_G	221_L	0.833	1.00
46_F	51_Y	0.831	1.00
218_L	221_L	0.830	1.00
49_G	71_I	0.828	1.00
165_K	169_L	0.825	1.00
81_K	124_K	0.825	1.00
210_G	213_I	0.825	1.00
303_L	307_F	0.824	1.00
228_L	231_K	0.823	1.00
180_L	183_L	0.821	1.00
19_Y	65_Q	0.821	1.00
166_L	169_L	0.816	1.00
198_Y	202_L	0.816	1.00
30_E	33_E	0.815	1.00
93_S	96_L	0.815	1.00
164_K	179_L	0.814	1.00
309_F	313_L	0.812	1.00
75_F	113_G	0.809	1.00
183_L	186_S	0.808	1.00
129_K	133_K	0.807	1.00
119_F	134_F	0.795	1.00
218_L	222_F	0.793	1.00
48_P	52_L	0.790	1.00
248_Y	252_L	0.790	1.00
53_L	57_L	0.790	1.00
122_A	126_L	0.782	1.00
168_L	172_I	0.782	1.00
251_G	255_L	0.777	1.00
204_S	207_S	0.777	1.00
5_L	8_F	0.775	1.00
53_L	67_F	0.773	1.00
134_F	155_Y	0.773	1.00
71_I	75_F	0.768	1.00
125_Y	134_F	0.767	1.00
235_K	238_K	0.765	1.00
143_L	146_K	0.763	1.00
274_I	277_I	0.761	1.00
32_F	64_Y	0.759	1.00
297_L	305_F	0.758	1.00
19_Y	22_G	0.757	1.00
247_L	251_G	0.751	1.00
119_F	138_I	0.750	1.00
19_Y	29_L	0.746	1.00
125_Y	130_K	0.744	1.00
275_F	279_L	0.743	1.00
138_I	151_F	0.742	1.00
51_Y	54_N	0.741	1.00
22_G	25_Y	0.741	1.00
10_L	14_F	0.737	1.00
3_L	7_L	0.733	1.00
165_K	168_L	0.733	1.00
123_L	127_L	0.732	1.00
113_G	117_A	0.729	1.00
269_A	273_L	0.728	1.00
160_K	164_K	0.728	1.00
215_V	222_F	0.727	1.00
21_V	107_M	0.726	1.00
291_K	294_K	0.724	1.00
252_L	256_L	0.724	1.00
149_L	153_P	0.722	1.00
129_K	159_K	0.719	1.00
251_G	273_L	0.716	1.00
153_P	158_A	0.715	1.00
16_G	72_A	0.711	1.00
216_G	222_F	0.708	1.00
78_L	81_K	0.707	1.00
305_F	309_F	0.705	1.00
163_K	166_L	0.704	1.00
128_K	132_I	0.703	1.00
116_I	271_Y	0.703	1.00
141_A	144_F	0.700	1.00
253_L	256_L	0.698	1.00
52_L	55_K	0.697	1.00
135_L	139_L	0.695	1.00
124_K	127_L	0.694	1.00
33_E	64_Y	0.693	1.00
25_Y	107_M	0.693	1.00
18_R	72_A	0.691	1.00
104_F	108_N	0.689	1.00
308_F	314_N	0.687	1.00
155_Y	158_A	0.685	1.00
138_I	141_A	0.685	1.00
232_I	235_K	0.684	1.00
177_L	180_L	0.681	1.00
302_L	306_L	0.677	1.00
56_L	60_L	0.676	1.00
8_F	76_I	0.675	1.00
105_V	112_Q	0.671	1.00
124_K	134_F	0.671	1.00
132_I	136_L	0.669	1.00
230_K	235_K	0.668	1.00
98_F	102_F	0.667	1.00
135_L	152_L	0.666	1.00
214_R	218_L	0.664	1.00
298_L	302_L	0.664	1.00
54_N	57_L	0.661	1.00
175_L	179_L	0.658	1.00
111_R	146_K	0.656	1.00
179_L	183_L	0.656	1.00
311_S	316_G	0.655	1.00
18_R	21_V	0.655	1.00
233_K	237_K	0.655	1.00
76_I	79_L	0.655	1.00
310_Y	314_N	0.652	1.00
216_G	230_K	0.651	1.00
84_K	87_S	0.648	1.00
281_P	284_L	0.647	1.00
303_L	306_L	0.646	1.00
57_L	60_L	0.645	1.00
185_L	189_S	0.645	1.00
231_K	235_K	0.643	1.00
225_F	229_F	0.642	1.00
120_L	274_I	0.642	1.00
221_L	224_L	0.641	1.00
280_L	283_L	0.636	1.00
15_A	76_I	0.632	1.00
164_K	168_L	0.631	0.99
227_L	230_K	0.631	0.99
119_F	122_A	0.629	0.99
121_L	125_Y	0.627	0.99
98_F	101_L	0.627	0.99
114_L	118_I	0.627	0.99
84_K	90_P	0.626	0.99
310_Y	313_L	0.626	0.99
13_L	16_G	0.625	0.99
119_F	123_L	0.625	0.99
311_S	314_N	0.623	0.99
167_L	170_L	0.622	0.99
248_Y	251_G	0.622	0.99
199_S	203_E	0.620	0.99
49_G	53_L	0.617	0.99
75_F	82_F	0.617	0.99
18_R	68_F	0.617	0.99
183_L	187_L	0.614	0.99
297_L	304_Y	0.610	0.99
12_I	17_L	0.610	0.99
263_P	266_D	0.609	0.99
151_F	271_Y	0.606	0.99
165_K	172_I	0.606	0.99
178_L	182_S	0.605	0.99
148_A	151_F	0.603	0.99
170_L	174_I	0.603	0.99
171_L	174_I	0.601	0.99
101_L	104_F	0.601	0.99
314_N	317_D	0.600	0.99
246_N	253_L	0.600	0.99
54_N	71_I	0.598	0.99
114_L	117_A	0.598	0.99
35_I	58_K	0.598	0.99
58_K	61_G	0.598	0.99
203_E	206_Y	0.596	0.99
301_I	305_F	0.596	0.99
134_F	151_F	0.595	0.99
220_L	223_I	0.592	0.99
219_L	222_F	0.590	0.99
249_L	253_L	0.590	0.99
299_I	303_L	0.589	0.99
154_L	247_L	0.582	0.99
86_Y	244_L	0.581	0.99
5_L	9_L	0.579	0.99
251_G	254_L	0.578	0.99
230_K	236_K	0.577	0.99
303_L	311_S	0.576	0.99
75_F	97_F	0.576	0.99
174_I	178_L	0.575	0.99
139_L	142_S	0.574	0.99
278_I	285_S	0.572	0.99
25_Y	109_G	0.572	0.99
57_L	64_Y	0.571	0.99
60_L	66_V	0.570	0.99
258_F	262_S	0.570	0.99
220_L	224_L	0.568	0.99
104_F	107_M	0.566	0.99
297_L	312_L	0.566	0.99
119_F	275_F	0.565	0.99
217_L	220_L	0.565	0.99
100_L	105_V	0.559	0.99
247_L	275_F	0.556	0.99
87_S	90_P	0.555	0.99
33_E	36_S	0.551	0.99
244_L	248_Y	0.549	0.99
26_Y	29_L	0.548	0.99
154_L	272_F	0.548	0.99
312_L	316_G	0.547	0.99
206_Y	209_G	0.547	0.99
209_G	212_L	0.546	0.99
135_L	155_Y	0.545	0.99
229_F	233_K	0.544	0.99
108_N	113_G	0.544	0.99
203_E	207_S	0.543	0.98
83_I	87_S	0.543	0.98
15_A	18_R	0.542	0.98
10_L	13_L	0.541	0.98
18_R	108_N	0.539	0.98
35_I	55_K	0.537	0.98
50_F	144_F	0.536	0.98
300_L	304_Y	0.536	0.98
127_L	131_L	0.536	0.98
232_I	236_K	0.536	0.98
50_F	67_F	0.534	0.98
35_I	38_G	0.534	0.98
79_L	97_F	0.534	0.98
151_F	154_L	0.533	0.98
161_K	164_K	0.531	0.98
308_F	313_L	0.531	0.98
279_L	283_L	0.529	0.98
257_L	260_F	0.527	0.98
112_Q	148_A	0.527	0.98
82_F	278_I	0.526	0.98
17_L	25_Y	0.526	0.98
35_I	39_S	0.525	0.98
129_K	158_A	0.525	0.98
146_K	197_K	0.524	0.98
153_P	272_F	0.524	0.98
235_K	239_E	0.524	0.98
272_F	275_F	0.523	0.98
31_I	34_N	0.523	0.98
301_I	306_L	0.522	0.98
101_L	105_V	0.522	0.98
165_K	179_L	0.522	0.98
215_V	218_L	0.521	0.98
46_F	49_G	0.519	0.98
246_N	254_L	0.519	0.98
266_D	270_L	0.519	0.98
73_L	76_I	0.517	0.98
96_L	277_I	0.516	0.98
304_Y	311_S	0.515	0.98
11_L	15_A	0.513	0.98
304_Y	307_F	0.512	0.98
20_G	29_L	0.509	0.98
246_N	250_I	0.504	0.98
32_F	58_K	0.504	0.98
184_I	188_L	0.502	0.98
156_F	160_K	0.501	0.97
120_L	275_F	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rceA	1	0.9172	3.8	0.946	Contact Map
2m7cA	1	0.0613	1	0.961	Contact Map
2l2tA	2	0.135	1	0.961	Contact Map
4gbfA	1	0.1718	1	0.961	Contact Map
2k3cA	1	0.0951	0.8	0.963	Contact Map
4w251	1	0.0828	0.6	0.967	Contact Map
1m56D	1	0.0583	0.5	0.968	Contact Map
3b5dA	2	0.2914	0.5	0.968	Contact Map
2jwaA	2	0.1288	0.5	0.968	Contact Map
2z73A	2	0.7975	0.5	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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