GREMLIN Database
DUF4470 - Domain of unknown function (DUF4470)
PFAM: PF14737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (95)
Sequences: 836 (698)
Seq/√Len: 71.6
META: 0.273

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_N49_H4.5481.00
69_L89_I4.0441.00
19_D47_K3.5191.00
30_L90_W3.3431.00
35_K39_S3.1631.00
4_N54_D2.4161.00
3_G31_R2.1511.00
88_E92_N2.1321.00
30_L67_L2.0971.00
10_L24_L1.9281.00
59_V63_N1.8321.00
30_L66_L1.6981.00
27_S63_N1.6901.00
81_E84_E1.6541.00
5_T31_R1.6250.99
4_N28_G1.5690.99
70_L86_F1.5300.99
24_L27_S1.5130.99
28_G54_D1.4720.99
87_L92_N1.4590.99
19_D46_R1.4490.99
9_D13_L1.4110.98
29_D36_T1.3980.98
69_L85_L1.3590.98
9_D40_L1.3220.98
60_L63_N1.3030.97
10_L36_T1.2960.97
11_L43_D1.2610.97
43_D89_I1.2340.96
26_G59_V1.2300.96
24_L50_F1.2300.96
7_A36_T1.1840.95
14_L18_E1.1720.95
25_L53_N1.1630.95
27_S60_L1.1610.95
4_N59_V1.1580.95
19_D88_E1.1310.94
23_L38_A1.1140.94
78_G81_E1.1110.93
51_T54_D1.1080.93
67_L83_A1.0900.93
72_D84_E1.0900.93
24_L66_L1.0650.92
8_L45_S1.0480.91
7_A68_T1.0300.91
34_L37_L0.9970.89
69_L77_L0.9890.89
6_P9_D0.9650.88
42_S66_L0.9620.87
1_P67_L0.9600.87
82_A88_E0.9570.87
25_L66_L0.9410.86
2_W5_T0.9390.86
64_L67_L0.9340.86
28_G31_R0.9220.85
87_L91_Y0.9160.85
81_E85_L0.9050.84
82_A92_N0.8970.83
14_L33_V0.8740.82
80_R95_I0.8680.81
2_W13_L0.8560.80
88_E91_Y0.8390.79
32_H82_A0.8390.79
86_F91_Y0.8070.76
26_G31_R0.8040.76
24_L48_L0.8000.76
86_F92_N0.7990.76
75_D78_G0.7900.75
2_W83_A0.7860.74
47_K83_A0.7670.73
4_N55_I0.7660.73
29_D34_L0.7640.72
36_T65_L0.7550.71
17_E20_L0.7350.69
54_D63_N0.7260.68
38_A87_L0.7210.68
20_L49_H0.7150.67
13_L22_I0.7130.67
38_A43_D0.7020.66
12_Q85_L0.6990.66
12_Q45_S0.6980.65
37_L40_L0.6980.65
9_D17_E0.6890.64
57_P61_A0.6860.64
11_L40_L0.6840.64
73_L80_R0.6780.63
21_N47_K0.6730.63
82_A85_L0.6730.63
43_D46_R0.6640.62
83_A87_L0.6600.61
30_L63_N0.6590.61
58_E80_R0.6560.61
2_W9_D0.6530.60
40_L48_L0.6500.60
58_E93_A0.6460.59
15_P20_L0.6450.59
42_S45_S0.6440.59
25_L28_G0.6420.59
30_L34_L0.6420.59
23_L71_L0.6380.59
10_L69_L0.6350.58
13_L60_L0.6330.58
69_L95_I0.6320.58
14_L17_E0.6290.57
30_L71_L0.6200.56
50_F59_V0.6200.56
8_L13_L0.6150.56
8_L24_L0.6120.55
10_L15_P0.6030.54
50_F56_E0.6030.54
11_L18_E0.6020.54
41_P44_Y0.5940.53
67_L71_L0.5920.53
13_L19_D0.5900.53
68_T72_D0.5900.53
33_V56_E0.5890.53
45_S66_L0.5800.51
9_D12_Q0.5720.51
4_N63_N0.5710.50
18_E50_F0.5680.50
28_G59_V0.5650.50
49_H74_P0.5650.50
45_S72_D0.5640.50
37_L42_S0.5580.49
57_P60_L0.5550.48
78_G82_A0.5540.48
13_L41_P0.5510.48
40_L46_R0.5450.47
24_L63_N0.5420.47
39_S42_S0.5370.46
49_H52_L0.5330.46
23_L61_A0.5290.45
24_L90_W0.5280.45
27_S79_L0.5270.45
3_G29_D0.5200.44
51_T86_F0.5200.44
61_A65_L0.5200.44
37_L90_W0.5190.44
58_E65_L0.5150.44
24_L40_L0.5100.43
54_D62_R0.5010.42
34_L58_E0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ppvA 2 0.9579 32.4 0.88 Contact Map
2o2zA 2 0.9474 26.9 0.884 Contact Map
2q7xA 2 0.6842 26.7 0.884 Contact Map
1vptA 2 0.9158 23.9 0.887 Contact Map
3magA 2 0.9158 21.5 0.89 Contact Map
4nnjA 2 0.8947 19.6 0.891 Contact Map
2jhpA 1 0.9789 16.3 0.895 Contact Map
1y8qB 1 0.8421 15.3 0.897 Contact Map
1pc6A 2 0.8211 13.8 0.899 Contact Map
4ii2A 1 0.8947 13.3 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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