GREMLIN Database
PHM7_cyt - Cytosolic domain of 10TM putative phosphate transporter
PFAM: PF14703 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (77)
Sequences: 2008 (1333)
Seq/√Len: 151.9
META: 0.305

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E76_R4.6531.00
52_H66_A4.4721.00
49_R65_D3.5021.00
18_A74_L2.8551.00
66_A70_Y2.4491.00
37_R41_L2.1991.00
26_E71_T1.6391.00
25_A66_A1.6041.00
5_V9_P1.5341.00
12_V16_D1.5081.00
58_G61_G1.5081.00
23_E27_A1.5051.00
71_T75_K1.4391.00
40_A44_G1.4021.00
40_A43_K1.3841.00
54_T60_F1.3651.00
44_G47_P1.3481.00
41_L47_P1.3251.00
14_E73_E1.3111.00
42_K45_K1.2991.00
55_G58_G1.2881.00
18_A70_Y1.2811.00
56_F60_F1.2621.00
14_E77_L1.2481.00
29_Y67_I1.2401.00
41_L44_G1.2011.00
14_E76_R1.1511.00
38_L42_K1.1471.00
37_R40_A1.1391.00
34_N37_R1.1381.00
40_A45_K1.1241.00
72_E76_R1.1210.99
15_R26_E1.1170.99
43_K46_K1.1160.99
32_N36_L1.0610.99
2_V5_V1.0530.99
29_Y33_A1.0120.99
19_V74_L1.0100.99
19_V23_E0.9850.99
38_L46_K0.9740.99
18_A77_L0.9630.98
52_H64_V0.9610.98
30_L34_N0.9610.98
72_E75_K0.9510.98
50_P67_I0.9510.98
26_E29_Y0.9370.98
39_K46_K0.9260.98
11_L14_E0.9250.98
15_R19_V0.9160.98
38_L44_G0.9110.98
6_K9_P0.9030.98
41_L46_K0.8940.98
65_D68_D0.8940.98
9_P13_E0.8900.97
39_K42_K0.8860.97
24_Y28_K0.8790.97
17_K28_K0.8780.97
42_K47_P0.8620.97
41_L45_K0.8560.97
40_A47_P0.8350.96
51_T63_K0.8350.96
66_A69_Y0.8260.96
16_D20_R0.7900.95
43_K47_P0.7870.95
55_G59_L0.7800.95
11_L77_L0.7750.94
40_A46_K0.7570.94
38_L43_K0.7510.93
26_E31_K0.7420.93
30_L63_K0.7270.92
35_K38_L0.7100.91
14_E18_A0.7100.91
38_L41_L0.7090.91
5_V20_R0.7010.91
54_T61_G0.7000.91
13_E17_K0.6860.90
39_K43_K0.6710.89
16_D19_V0.6700.89
22_L65_D0.6630.88
5_V74_L0.6570.88
52_H70_Y0.6520.87
49_R68_D0.6430.87
74_L77_L0.6420.87
34_N38_L0.6310.86
42_K46_K0.6260.85
52_H69_Y0.6250.85
21_K70_Y0.6150.84
2_V71_T0.6140.84
68_D72_E0.6120.84
64_V76_R0.6070.83
10_K13_E0.6060.83
22_L67_I0.6020.83
16_D31_K0.5880.81
31_K34_N0.5800.81
5_V69_Y0.5640.79
22_L74_L0.5570.78
53_R63_K0.5570.78
32_N35_K0.5520.77
5_V19_V0.5440.76
20_R41_L0.5350.75
2_V15_R0.5350.75
1_I23_E0.5340.75
53_R56_F0.5340.75
2_V9_P0.5260.74
68_D75_K0.5230.73
36_L40_A0.5200.73
8_L23_E0.5150.72
12_V19_V0.5130.72
57_L60_F0.5130.72
9_P20_R0.5120.72
35_K42_K0.5070.71
23_E26_E0.5070.71
2_V26_E0.5060.71
28_K48_K0.5050.71
3_R9_P0.5020.70
4_D15_R0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l8dA 2 0.7308 10.4 0.865 Contact Map
1fsuA 1 0.7308 8.5 0.87 Contact Map
4fzsA 2 0.7564 4.3 0.886 Contact Map
4upkA 3 0.6923 3.8 0.89 Contact Map
2k4nA 1 0.3333 3.7 0.89 Contact Map
3ghgA 2 0.9487 3.6 0.89 Contact Map
2qzuA 2 0.5513 3.5 0.892 Contact Map
1xe1A 2 0.1154 3.3 0.892 Contact Map
2e52A 2 1 3.2 0.893 Contact Map
4uqzB 1 0 3.2 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0049 seconds.