GREMLIN Database
Vwaint - VWA / Hh protein intein-like
PFAM: PF14624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (64)
Sequences: 1132 (899)
Seq/√Len: 112.4
META: 0.739

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_H55_Y4.1911.00
5_A54_H3.0141.00
45_N52_V2.5031.00
37_R40_Q2.4441.00
37_R41_L2.3681.00
21_R25_E2.2841.00
20_R23_W2.1691.00
39_H51_G2.1231.00
13_Q23_W2.0801.00
38_A45_N1.7291.00
29_R33_L1.6231.00
63_L66_R1.5931.00
44_C64_R1.5561.00
62_E66_R1.5261.00
25_E29_R1.4731.00
46_N49_D1.4081.00
19_S23_W1.3801.00
14_V35_L1.3761.00
34_S45_N1.3541.00
16_E23_W1.3211.00
13_Q16_E1.3131.00
11_E58_P1.1280.99
35_L39_H1.1130.98
30_H33_L1.1070.98
12_G16_E1.1000.98
58_P62_E1.0960.98
46_N52_V1.0840.98
18_L32_L1.0470.98
57_G60_F1.0470.98
17_A45_N1.0390.97
63_L67_A1.0190.97
51_G55_Y1.0100.97
24_Y32_L1.0040.97
34_S44_C0.9680.96
58_P61_K0.9600.96
27_W46_N0.9370.95
42_Q57_G0.9300.95
7_L11_E0.9260.95
8_A25_E0.9140.95
17_A31_Y0.8940.94
38_A52_V0.8860.94
61_K65_D0.8740.93
13_Q48_K0.8730.93
27_W49_D0.8630.93
24_Y29_R0.8220.91
4_K10_L0.7630.87
27_W47_F0.7600.87
58_P66_R0.7460.86
24_Y33_L0.7440.86
35_L51_G0.7440.86
62_E65_D0.7280.85
5_A8_A0.7240.85
61_K64_R0.7200.84
7_L10_L0.6980.82
44_C61_K0.6950.82
31_Y35_L0.6940.82
23_W48_K0.6920.82
12_G42_Q0.6790.81
26_K56_G0.6790.81
41_L67_A0.6730.80
15_S19_S0.6710.80
13_Q17_A0.6700.80
56_G61_K0.6690.80
4_K7_L0.6590.79
59_L62_E0.6590.79
24_Y36_L0.6450.77
17_A27_W0.6420.77
4_K40_Q0.6410.77
18_L41_L0.6380.76
59_L63_L0.6260.75
36_L40_Q0.6180.74
18_L21_R0.6090.73
15_S25_E0.6000.72
29_R45_N0.5940.71
18_L36_L0.5920.71
32_L51_G0.5920.71
37_R50_P0.5870.70
57_G61_K0.5840.70
57_G63_L0.5700.68
56_G59_L0.5680.68
23_W26_K0.5680.68
35_L52_V0.5610.67
12_G27_W0.5570.66
52_V57_G0.5300.63
26_K34_S0.5280.62
30_H51_G0.5260.62
15_S62_E0.5250.62
33_L57_G0.5220.61
8_A11_E0.5210.61
36_L58_P0.5060.59
4_K36_L0.5050.59
13_Q45_N0.5050.59
27_W48_K0.5030.59
17_A32_L0.5010.58
4_K25_E0.5010.58
25_E37_R0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vw1A 5 1 27.1 0.857 Contact Map
2ixoA 1 0.9565 11 0.881 Contact Map
2ixnA 1 0.9275 9.5 0.884 Contact Map
1yvlA 3 0.8986 9.5 0.884 Contact Map
2ixmA 1 0.9565 9.3 0.885 Contact Map
2vsqA 1 0.971 8.7 0.886 Contact Map
1cp2A 2 0.4058 7.7 0.889 Contact Map
4ziaA 2 0.8986 6.9 0.891 Contact Map
3t5oA 1 0.9855 6.7 0.892 Contact Map
4e04A 2 0.3768 6.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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