GREMLIN Database
SnAC - Snf2-ATP coupling, chromatin remodelling complex
PFAM: PF14619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (74)
Sequences: 652 (517)
Seq/√Len: 60.1
META: 0.313

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R7_A4.0981.00
11_D14_G2.6781.00
10_W14_G2.4061.00
67_D72_E2.3771.00
3_R7_A2.3651.00
11_D15_G2.3441.00
34_Y73_E2.1641.00
71_T74_Q2.1171.00
15_G18_K2.0061.00
11_D16_K1.8051.00
10_W13_E1.7850.99
72_E76_L1.7820.99
5_E8_E1.6150.99
65_K74_Q1.5820.99
4_R9_E1.5480.98
30_L34_Y1.5200.98
47_E50_E1.4990.98
33_W73_E1.4660.98
12_E15_G1.4620.98
14_G18_K1.3540.96
30_L56_R1.3490.96
30_L37_D1.3470.96
58_A62_K1.2990.95
39_N42_E1.2880.95
3_R6_E1.2810.95
13_E16_K1.2290.94
11_D18_K1.2170.94
12_E16_K1.1940.93
21_P54_Y1.1850.93
6_E23_R1.1500.91
5_E9_E1.1450.91
44_E48_E1.1090.90
2_R5_E1.0980.89
69_G73_E1.0960.89
30_L35_L1.0580.88
33_W60_E1.0580.88
11_D17_G1.0300.86
37_D54_Y1.0190.86
34_Y74_Q0.9890.84
43_E46_K0.9730.83
25_M54_Y0.9660.82
67_D73_E0.9310.80
64_V69_G0.9300.80
32_E68_D0.9280.80
34_Y65_K0.9210.79
69_G74_Q0.9040.78
54_Y57_G0.8820.76
41_E44_E0.8800.76
19_P74_Q0.8480.73
10_W16_K0.8330.72
34_Y57_G0.8290.72
22_P26_E0.8260.71
71_T75_W0.8050.69
36_K62_K0.8040.69
40_E43_E0.7980.69
50_E53_E0.7960.69
37_D72_E0.7880.68
31_P64_V0.7720.66
34_Y37_D0.7550.64
26_E71_T0.7550.64
44_E49_E0.7400.63
28_D35_L0.7350.62
16_K20_R0.7290.62
22_P28_D0.7250.61
62_K65_K0.7080.59
30_L72_E0.6990.58
25_M68_D0.6980.58
42_E46_K0.6970.58
15_G20_R0.6820.57
67_D70_L0.6770.56
10_W17_G0.6710.55
10_W15_G0.6670.55
15_G19_P0.6600.54
41_E70_L0.6570.54
23_R62_K0.6520.53
60_E63_E0.6500.53
25_M74_Q0.6460.53
37_D41_E0.6400.52
47_E52_E0.6330.51
23_R74_Q0.6310.51
33_W63_E0.6300.51
51_E54_Y0.6280.51
5_E46_K0.6230.50
6_E9_E0.6090.48
4_R8_E0.6040.48
13_E17_G0.5890.46
27_E57_G0.5880.46
14_G17_G0.5860.46
16_K75_W0.5860.46
54_Y67_D0.5840.46
51_E64_V0.5770.45
27_E55_G0.5720.44
37_D75_W0.5710.44
58_A61_R0.5680.44
46_K49_E0.5660.44
19_P75_W0.5590.43
18_K21_P0.5590.43
50_E54_Y0.5580.43
29_E75_W0.5560.43
42_E45_E0.5540.42
27_E70_L0.5390.41
56_R60_E0.5380.41
23_R33_W0.5300.40
50_E56_R0.5300.40
53_E61_R0.5210.39
27_E72_E0.5170.38
20_R35_L0.5150.38
32_E52_E0.5050.37
26_E35_L0.5030.37
41_E45_E0.5000.37
14_G20_R0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yu1A 1 0 7.1 0.886 Contact Map
3wxwA 1 0.5921 6.2 0.889 Contact Map
1qb3A 2 0.7763 3.4 0.902 Contact Map
3qy2A 4 0.8421 2.7 0.908 Contact Map
3gjxB 1 0.6447 2.4 0.909 Contact Map
4f1nA 1 0.8026 2.1 0.912 Contact Map
4mp0B 1 0.2105 2.1 0.912 Contact Map
3cxjA 3 0.7763 1.9 0.914 Contact Map
4kreA 1 0.7763 1.9 0.914 Contact Map
2yhbA 1 0.8421 1.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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