GREMLIN Database
SseB_C - SseB protein C-terminal domain
PFAM: PF14581 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 2185 (1598)
Seq/√Len: 156.7
META: 0.759

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_F36_A4.3581.00
34_R55_E3.3691.00
15_Y20_V2.8671.00
23_L27_F2.5851.00
30_R66_A2.5361.00
27_F67_A2.5181.00
26_L30_R2.3451.00
27_F33_V2.2851.00
26_L66_A2.2651.00
36_A103_F2.1481.00
52_I83_F2.1481.00
34_R57_D2.0241.00
53_G86_L2.0191.00
93_S96_L1.8481.00
61_E65_R1.7941.00
26_L70_V1.7391.00
41_V51_L1.6241.00
10_G40_L1.6011.00
9_L41_V1.5361.00
17_T21_A1.5321.00
35_A105_E1.4911.00
66_A69_E1.4511.00
101_R105_E1.4451.00
18_E21_A1.4421.00
49_H82_D1.4391.00
22_A25_A1.4271.00
67_A83_F1.4151.00
52_I81_V1.4011.00
95_W99_N1.3881.00
30_R63_L1.3861.00
40_L50_L1.3681.00
92_V95_W1.3611.00
53_G96_L1.3611.00
42_Q45_G1.3131.00
16_P20_V1.3111.00
88_D93_S1.2781.00
90_Q94_D1.2481.00
27_F103_F1.2291.00
56_L60_W1.2261.00
95_W98_E1.2031.00
67_A71_A1.1911.00
39_A100_V1.1801.00
21_A25_A1.1461.00
86_L97_L1.1411.00
60_W85_P1.0820.99
54_V85_P1.0800.99
75_L78_G1.0760.99
94_D98_E1.0690.99
13_A16_P1.0590.99
8_L42_Q1.0580.99
20_V24_S1.0560.99
75_L80_P1.0360.99
26_L63_L1.0300.99
40_L48_P0.9950.99
14_E17_T0.9830.99
50_L53_G0.9760.99
12_P15_Y0.9740.99
5_T8_L0.9720.99
75_L81_V0.9720.99
59_D62_E0.9650.99
51_L82_D0.9550.99
64_V83_F0.9330.98
27_F54_V0.8980.98
22_A70_V0.8950.98
11_E100_V0.8740.97
24_S28_A0.8610.97
34_R106_R0.8390.97
28_A104_Y0.8180.96
36_A54_V0.8110.96
62_E65_R0.8070.96
39_A51_L0.8050.96
11_E15_Y0.7960.96
76_P79_E0.7850.95
17_T20_V0.7830.95
56_L85_P0.7800.95
60_W64_V0.7680.95
14_E79_E0.7550.94
12_P40_L0.7500.94
25_A32_E0.7500.94
37_Y86_L0.7460.94
5_T43_V0.7450.94
18_E74_A0.7440.94
26_L29_K0.7370.93
3_K7_V0.7330.93
38_L52_I0.7280.93
35_A86_L0.7280.93
35_A55_E0.7190.92
96_L99_N0.7100.92
43_V49_H0.7080.92
99_N105_E0.7060.92
92_V96_L0.7040.92
93_S97_L0.6970.91
75_L79_E0.6910.91
96_L100_V0.6900.91
89_E93_S0.6890.91
20_V38_L0.6850.90
42_Q48_P0.6800.90
55_E93_S0.6730.90
6_Q44_P0.6710.90
62_E66_A0.6700.90
14_E20_V0.6690.89
66_A70_V0.6590.89
70_V74_A0.6580.89
41_V82_D0.6560.89
17_T24_S0.6520.88
11_E95_W0.6480.88
29_K34_R0.6420.87
10_G13_A0.6410.87
91_G94_D0.6330.87
19_L76_P0.6250.86
75_L82_D0.6210.86
90_Q93_S0.6200.86
29_K78_G0.6160.85
46_E88_D0.6100.85
69_E72_A0.5980.83
22_A55_E0.5970.83
13_A17_T0.5950.83
36_A52_I0.5950.83
39_A96_L0.5930.83
94_D101_R0.5930.83
47_E80_P0.5880.82
51_L84_V0.5860.82
42_Q50_L0.5840.82
66_A73_G0.5820.82
41_V49_H0.5810.82
14_E33_V0.5770.81
33_V67_A0.5740.81
28_A31_P0.5730.81
39_A97_L0.5700.80
68_G83_F0.5700.80
44_P72_A0.5660.80
23_L68_G0.5590.79
44_P74_A0.5580.79
41_V75_L0.5580.79
34_R46_E0.5560.79
36_A67_A0.5480.78
3_K45_G0.5480.78
49_H80_P0.5420.77
55_E88_D0.5420.77
18_E76_P0.5400.77
36_A63_L0.5360.76
21_A106_R0.5320.76
9_L86_L0.5300.76
5_T13_A0.5290.75
52_I55_E0.5290.75
10_G82_D0.5270.75
34_R101_R0.5260.75
58_G61_E0.5260.75
64_V73_G0.5210.74
7_V11_E0.5140.73
70_V73_G0.5080.72
16_P71_A0.5060.72
33_V104_Y0.5020.72
34_R105_E0.5010.71
34_R58_G0.5010.71
61_E77_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rffA 1 0.934 79.5 0.801 Contact Map
1no5A 4 0.9057 45.4 0.841 Contact Map
3c18A 2 0.783 33.2 0.853 Contact Map
1wotA 1 0.8774 22.5 0.865 Contact Map
2pbeA 1 0.783 18.6 0.87 Contact Map
1ylqA 2 0.8113 15.7 0.874 Contact Map
4d4iA 1 0.6509 11.4 0.882 Contact Map
4kgbA 2 0.9057 11 0.882 Contact Map
3ivrA 2 0.0094 10.9 0.883 Contact Map
2ahuA 3 0.9528 10.9 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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