GREMLIN Database
Peptidase_S78_2 - Putative phage serine protease XkdF
PFAM: PF14550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (111)
Sequences: 6682 (4855)
Seq/√Len: 460.8
META: 0.974

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_Y90_G3.1631.00
11_E103_K3.1001.00
101_K106_E2.8161.00
19_V89_V2.6051.00
91_V110_F2.4221.00
100_E104_S2.2551.00
17_G110_F2.2101.00
13_R96_D2.1881.00
13_R99_W2.1391.00
12_K38_E2.0791.00
14_I90_G2.0101.00
68_S87_W1.9201.00
18_P21_I1.8581.00
52_N113_E1.7931.00
34_K84_K1.7541.00
64_T94_D1.7391.00
72_D75_S1.6891.00
51_V91_V1.6791.00
53_L107_L1.6381.00
23_D34_K1.6311.00
72_D76_K1.5641.00
43_K47_N1.5611.00
14_I92_K1.5041.00
26_D30_D1.4681.00
65_V91_V1.4681.00
41_A68_S1.4431.00
46_K94_D1.4091.00
38_E42_E1.4011.00
46_K64_T1.3921.00
65_V89_V1.3811.00
33_S36_T1.3301.00
71_V88_M1.3021.00
20_L32_F1.2931.00
14_I66_V1.2701.00
46_K92_K1.2681.00
22_P86_T1.2521.00
24_R27_A1.2371.00
96_D100_E1.1981.00
101_K104_S1.1811.00
25_V31_Y1.1761.00
72_D77_L1.1741.00
101_K107_L1.1681.00
41_A45_M1.1561.00
36_T39_K1.1521.00
53_L98_V1.1391.00
97_E101_K1.1361.00
15_V93_V1.1181.00
53_L101_K1.1091.00
67_E90_G1.1011.00
57_G113_E1.0871.00
24_R29_G1.0841.00
18_P86_T1.0821.00
24_R30_D1.0791.00
25_V29_G1.0611.00
75_S78_G1.0581.00
83_P86_T1.0491.00
99_W102_V1.0381.00
45_M68_S1.0361.00
42_E67_E1.0301.00
10_E103_K1.0111.00
25_V30_D1.0041.00
7_K10_E1.0001.00
82_V88_M0.9731.00
76_K79_G0.9641.00
19_V112_I0.9631.00
71_V82_V0.9591.00
73_D78_G0.9581.00
51_V63_G0.9551.00
25_V28_Q0.9511.00
20_L112_I0.9441.00
63_G98_V0.9351.00
21_I83_P0.9281.00
82_V86_T0.9231.00
73_D76_K0.9141.00
21_I86_T0.9121.00
52_N56_D0.8991.00
62_G95_D0.8911.00
44_F65_V0.8891.00
42_E92_K0.8801.00
69_W88_M0.8581.00
41_A70_I0.8511.00
42_E66_V0.8491.00
11_E99_W0.8481.00
15_V102_V0.8401.00
16_Y88_M0.8401.00
99_W103_K0.8381.00
35_E39_K0.8211.00
74_K77_L0.8081.00
26_D29_G0.8071.00
27_A30_D0.8061.00
96_D99_W0.7961.00
41_A87_W0.7951.00
18_P88_M0.7921.00
26_D31_Y0.7531.00
52_N57_G0.7471.00
21_I24_R0.7411.00
24_R31_Y0.7391.00
54_M107_L0.7371.00
93_V99_W0.7361.00
32_F40_A0.7341.00
98_V107_L0.7251.00
20_L37_I0.7151.00
18_P82_V0.7151.00
18_P22_P0.7121.00
73_D79_G0.7101.00
45_M49_R0.7061.00
28_Q31_Y0.6981.00
93_V102_V0.6981.00
32_F37_I0.6921.00
49_R64_T0.6901.00
24_R28_Q0.6871.00
63_G93_V0.6851.00
74_K78_G0.6791.00
40_A43_K0.6731.00
34_K37_I0.6711.00
71_V75_S0.6671.00
76_K81_D0.6671.00
9_D12_K0.6621.00
73_D77_L0.6561.00
71_V84_K0.6511.00
16_Y42_E0.6411.00
75_S79_G0.6371.00
44_F91_V0.6260.99
100_E103_K0.6250.99
62_G94_D0.6170.99
72_D78_G0.6050.99
105_G108_K0.6040.99
44_F87_W0.6030.99
75_S80_L0.6020.99
20_L40_A0.6000.99
74_K80_L0.5980.99
40_A114_G0.5970.99
74_K79_G0.5970.99
97_E100_E0.5960.99
63_G94_D0.5950.99
67_E70_I0.5940.99
56_D59_K0.5890.99
57_G61_G0.5830.99
20_L31_Y0.5770.99
38_E70_I0.5740.99
14_I42_E0.5740.99
16_Y69_W0.5710.99
43_K46_K0.5710.99
77_L80_L0.5620.99
32_F36_T0.5620.99
42_E45_M0.5520.99
13_R92_K0.5510.99
36_T112_I0.5460.98
37_I41_A0.5460.98
45_M48_G0.5450.98
67_E71_V0.5420.98
44_F68_S0.5390.98
37_I40_A0.5350.98
50_N60_V0.5340.98
19_V65_V0.5280.98
10_E13_R0.5270.98
52_N61_G0.5260.98
68_S89_V0.5260.98
27_A31_Y0.5230.98
75_S82_V0.5180.98
12_K35_E0.5160.98
45_M64_T0.5140.98
45_M65_V0.5130.98
102_V107_L0.5130.98
32_F112_I0.5070.98
18_P83_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2re7A 2 0.725 6.3 0.921 Contact Map
2ovcA 3 0.1083 5.9 0.922 Contact Map
2aq6A 2 0.6333 5.4 0.923 Contact Map
1vzvA 2 0.7667 5.2 0.924 Contact Map
4ehiA 2 0.4 5.1 0.924 Contact Map
3u1wA 3 0.7167 4.1 0.928 Contact Map
4w23R 1 0.6333 4.1 0.928 Contact Map
3zeyL 1 0.625 3.4 0.931 Contact Map
4h3wA 1 0.4083 3.3 0.931 Contact Map
4wyhA 1 0.775 3.2 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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