GREMLIN Database
ABC_trans_N - ABC-transporter extracellular N-terminal
PFAM: PF14510 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (77)
Sequences: 1855 (1280)
Seq/√Len: 145.9
META: 0.171

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_Q11_E2.4071.00
13_D16_N2.3851.00
35_N39_L2.0861.00
74_R81_N1.9971.00
30_S33_F1.9891.00
36_E40_K1.9171.00
24_S32_E1.8911.00
12_V15_S1.8831.00
28_P33_F1.8051.00
23_D27_D1.7591.00
33_F68_G1.7461.00
61_F64_L1.6231.00
40_K44_N1.5981.00
14_V17_L1.5691.00
28_P76_Q1.5671.00
43_R57_I1.5471.00
8_Q12_V1.5231.00
69_V74_R1.5131.00
30_S38_W1.5121.00
13_D18_G1.5001.00
28_P38_W1.4821.00
77_P82_V1.4571.00
77_P81_N1.4431.00
43_R47_D1.4301.00
34_D51_I1.4031.00
9_S30_S1.3491.00
46_I56_T1.3071.00
42_L46_I1.2791.00
24_S27_D1.2471.00
73_T81_N1.2161.00
50_G54_P1.2031.00
79_V83_L1.1971.00
21_E27_D1.1891.00
39_L57_I1.1551.00
45_R59_V1.1400.99
35_N41_K1.1380.99
79_V82_V1.1370.99
69_V77_P1.1370.99
16_N19_L1.1360.99
70_G74_R1.0990.99
46_I53_L1.0660.99
69_V73_T1.0640.99
10_K20_Q1.0390.99
45_R48_R1.0370.99
14_V18_G1.0290.99
46_I54_P1.0090.99
61_F83_L1.0030.99
34_D37_K0.9810.98
75_Y81_N0.9530.98
38_W67_E0.9460.98
25_L37_K0.9340.98
60_R64_L0.9120.97
44_N48_R0.8950.97
27_D38_W0.8940.97
35_N59_V0.8880.97
36_E60_R0.8790.97
21_E32_E0.8780.97
10_K13_D0.8530.96
27_D30_S0.8410.96
55_R66_V0.8390.96
8_Q19_L0.8360.96
14_V19_L0.8300.96
57_I71_V0.8290.96
25_L29_L0.8240.95
34_D45_R0.8210.95
10_K24_S0.7980.95
51_I71_V0.7590.93
43_R54_P0.7480.93
24_S84_L0.7450.92
45_R54_P0.7400.92
47_D54_P0.7390.92
15_S20_Q0.7180.91
38_W70_G0.7070.90
28_P65_N0.7070.90
29_L59_V0.7050.90
39_L54_P0.7040.90
57_I64_L0.6890.89
39_L55_R0.6850.89
42_L55_R0.6840.89
39_L62_E0.6760.88
35_N61_F0.6740.88
50_G53_L0.6720.88
36_E51_I0.6690.88
38_W76_Q0.6620.87
45_R77_P0.6590.87
33_F40_K0.6440.86
66_V70_G0.6430.86
55_R77_P0.6370.85
52_E83_L0.6340.85
27_D68_G0.6260.84
43_R59_V0.6240.84
47_D52_E0.6210.84
33_F58_G0.6160.83
61_F72_G0.6140.83
73_T77_P0.6060.82
42_L47_D0.6010.81
33_F38_W0.6000.81
39_L67_E0.5830.80
48_R51_I0.5820.79
20_Q24_S0.5810.79
28_P79_V0.5800.79
15_S18_G0.5790.79
80_G84_L0.5730.78
76_Q79_V0.5580.77
49_V62_E0.5580.77
10_K63_N0.5560.76
61_F79_V0.5550.76
15_S68_G0.5520.76
12_V16_N0.5370.74
56_T60_R0.5190.71
15_S19_L0.5140.71
20_Q63_N0.5110.70
75_Y80_G0.5090.70
43_R55_R0.5050.69
52_E56_T0.5010.69
49_V57_I0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1unnC 1 0.8235 6.6 0.901 Contact Map
2qtcA 2 0.0706 6.1 0.902 Contact Map
2im5A 1 0.9529 5.9 0.903 Contact Map
3mfiA 1 0.7765 4.6 0.908 Contact Map
3os4A 1 0.9412 4.3 0.909 Contact Map
3sscA 1 0.6118 4.2 0.909 Contact Map
1vjuA 1 0.9294 4 0.91 Contact Map
4pl9A 1 0.6941 3.8 0.912 Contact Map
3j4aA 3 0.9412 3.5 0.913 Contact Map
4tqrA 1 0.7294 3.4 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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