GREMLIN Database
DUF4433 - Domain of unknown function (DUF4433)
PFAM: PF14487 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 204 (201)
Sequences: 4648 (4061)
Seq/√Len: 286.5
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_K183_E5.3261.00
130_I135_I4.8021.00
110_G117_T3.2031.00
4_T12_I3.0851.00
110_G151_R3.0561.00
22_N58_D2.9611.00
9_L182_V2.7851.00
23_E26_E2.7841.00
170_G197_E2.7811.00
94_V170_G2.6841.00
17_G162_S2.5821.00
23_E161_D2.3881.00
131_D152_R2.3101.00
23_E27_R2.3091.00
176_E179_K2.2241.00
109_D118_E2.1181.00
104_G160_P2.0571.00
120_Y129_K2.0531.00
117_T151_R1.9411.00
109_D120_Y1.8911.00
178_V181_R1.8831.00
65_C153_K1.8821.00
125_D129_K1.8671.00
131_D134_A1.8501.00
95_I163_V1.8241.00
96_D169_E1.7761.00
40_Q57_H1.7611.00
36_D73_N1.7491.00
99_V169_E1.7051.00
93_L168_I1.6511.00
62_F163_V1.6121.00
7_D32_T1.6121.00
4_T8_N1.6121.00
175_N178_V1.5961.00
99_V102_E1.5681.00
173_V182_V1.5421.00
41_D45_T1.5371.00
88_E175_N1.5311.00
10_P185_L1.4981.00
55_T58_D1.4861.00
122_D125_D1.4821.00
88_E174_Y1.4711.00
14_E189_A1.4621.00
15_N27_R1.4471.00
165_W168_I1.4201.00
148_D152_R1.3871.00
15_N29_L1.3731.00
110_G114_S1.3691.00
15_N19_L1.3581.00
142_D149_R1.3481.00
2_H18_L1.3361.00
94_V172_G1.3311.00
148_D151_R1.2961.00
54_G59_Y1.2941.00
103_L164_P1.2851.00
108_T119_F1.2771.00
39_I113_A1.2691.00
71_L90_I1.2641.00
54_G161_D1.2631.00
93_L171_I1.2521.00
19_L24_L1.2461.00
108_T117_T1.2401.00
83_Y86_G1.1931.00
68_S71_L1.1861.00
164_P167_L1.1831.00
24_L29_L1.1791.00
54_G160_P1.1771.00
171_I182_V1.1711.00
135_I153_K1.1701.00
73_N77_R1.1681.00
159_V163_V1.1671.00
176_E180_E1.1341.00
105_F157_F1.1311.00
69_P153_K1.1311.00
59_Y106_V1.1231.00
114_S151_R1.1231.00
85_G89_D1.1191.00
101_V123_L1.1091.00
75_R78_G1.1011.00
174_Y178_V1.0861.00
152_R155_A1.0811.00
134_A152_R1.0771.00
46_R115_S1.0711.00
95_I168_I1.0681.00
9_L171_I1.0561.00
170_G199_R1.0551.00
60_V163_V1.0521.00
114_S117_T1.0431.00
19_L23_E1.0421.00
134_A137_A1.0391.00
174_Y200_P1.0371.00
9_L93_L1.0361.00
8_N31_Y1.0301.00
18_L60_V1.0301.00
21_R40_Q1.0281.00
123_L126_L1.0271.00
44_L57_H1.0271.00
180_E183_E1.0201.00
172_G202_W1.0121.00
18_L21_R1.0051.00
35_G40_Q0.9971.00
3_I92_I0.9931.00
34_I70_M0.9911.00
107_F122_D0.9831.00
176_E198_V0.9831.00
19_L162_S0.9761.00
9_L91_V0.9761.00
67_R71_L0.9761.00
39_I42_R0.9741.00
189_A192_H0.9731.00
51_P121_S0.9721.00
63_Y154_Q0.9711.00
47_P55_T0.9641.00
132_W135_I0.9581.00
89_D181_R0.9581.00
4_T31_Y0.9421.00
3_I90_I0.9401.00
56_L111_N0.9401.00
108_T112_A0.9401.00
59_Y160_P0.9271.00
177_A181_R0.9241.00
54_G58_D0.9241.00
141_R146_D0.9211.00
35_G57_H0.9201.00
20_S23_E0.9191.00
6_I178_V0.9051.00
69_P150_K0.9001.00
146_D152_R0.8971.00
20_S161_D0.8961.00
72_Y77_R0.8911.00
65_C68_S0.8851.00
10_P14_E0.8801.00
100_L159_V0.8801.00
38_E82_E0.8771.00
20_S24_L0.8771.00
134_A149_R0.8501.00
1_Y66_P0.8471.00
110_G148_D0.8451.00
36_D39_I0.8441.00
33_D37_P0.8421.00
5_H89_D0.8311.00
95_I99_V0.8301.00
111_N154_Q0.8281.00
21_R24_L0.8281.00
101_V105_F0.8241.00
181_R184_A0.8241.00
183_E187_A0.8181.00
73_N79_N0.8161.00
138_R201_D0.8131.00
71_L92_I0.8080.99
63_Y68_S0.8070.99
132_W136_F0.8060.99
94_V169_E0.8060.99
100_L163_V0.8040.99
186_L195_P0.8000.99
56_L61_P0.7940.99
11_S15_N0.7930.99
146_D149_R0.7890.99
181_R185_L0.7850.99
13_L165_W0.7800.99
42_R113_A0.7730.99
116_Y151_R0.7720.99
72_Y75_R0.7710.99
65_C92_I0.7660.99
24_L31_Y0.7610.99
105_F159_V0.7580.99
18_L22_N0.7550.99
76_H80_V0.7520.99
69_P154_Q0.7520.99
67_R92_I0.7510.99
68_S92_I0.7510.99
3_I34_I0.7490.99
50_V106_V0.7480.99
92_I172_G0.7470.99
73_N150_K0.7470.99
51_P106_V0.7460.99
182_V196_V0.7450.99
137_A149_R0.7420.99
165_W192_H0.7410.99
180_E184_A0.7370.99
48_V119_F0.7370.99
99_V167_L0.7320.99
21_R33_D0.7300.99
182_V185_L0.7290.99
133_D137_A0.7230.99
76_H79_N0.7210.99
173_V179_K0.7150.99
41_D44_L0.7110.99
67_R72_Y0.7080.99
102_E167_L0.7040.99
89_D178_V0.7030.99
131_D135_I0.7030.99
64_F107_F0.6960.98
77_R80_V0.6930.98
91_V173_V0.6930.98
97_L123_L0.6840.98
100_L157_F0.6830.98
65_C135_I0.6790.98
145_E149_R0.6790.98
46_R113_A0.6770.98
187_A190_G0.6730.98
39_I57_H0.6720.98
107_F126_L0.6690.98
190_G193_R0.6690.98
22_N26_E0.6660.98
110_G155_A0.6650.98
50_V119_F0.6640.98
49_P52_P0.6630.98
86_G89_D0.6630.98
103_L162_S0.6610.98
185_L188_A0.6590.98
22_N57_H0.6570.98
8_N11_S0.6550.98
74_I77_R0.6540.98
18_L24_L0.6530.98
70_M74_I0.6520.98
35_G39_I0.6480.98
34_I90_I0.6440.97
179_K198_V0.6410.97
106_V157_F0.6350.97
185_L189_A0.6330.97
94_V197_E0.6280.97
1_Y172_G0.6270.97
7_D89_D0.6270.97
31_Y34_I0.6250.97
163_V168_I0.6250.97
184_A187_A0.6250.97
143_D149_R0.6220.97
6_I181_R0.6210.97
140_W143_D0.6170.97
37_P41_D0.6170.97
139_D143_D0.6160.97
32_T85_G0.6160.97
88_E177_A0.6150.97
110_G152_R0.6140.97
172_G199_R0.6140.97
64_F157_F0.6120.97
83_Y89_D0.6100.96
27_R30_N0.6090.96
175_N200_P0.6070.96
96_D99_V0.6060.96
165_W194_P0.6040.96
68_S153_K0.6020.96
2_H11_S0.5990.96
177_A180_E0.5970.96
47_P53_G0.5960.96
31_Y35_G0.5920.96
168_I194_P0.5890.96
105_F160_P0.5880.96
130_I134_A0.5800.95
112_A158_L0.5790.95
72_Y76_H0.5770.95
142_D150_K0.5760.95
39_I111_N0.5720.95
48_V51_P0.5710.95
92_I203_Y0.5710.95
98_E102_E0.5690.95
21_R61_P0.5690.95
62_F157_F0.5680.95
199_R202_W0.5660.95
23_E162_S0.5660.95
123_L127_D0.5640.95
97_L101_V0.5630.95
142_D145_E0.5620.95
124_D127_D0.5610.94
184_A188_A0.5600.94
64_F130_I0.5600.94
47_P50_V0.5590.94
112_A119_F0.5590.94
186_L196_V0.5580.94
21_R57_H0.5570.94
34_I74_I0.5550.94
183_E196_V0.5550.94
71_L75_R0.5500.94
189_A197_E0.5500.94
2_H12_I0.5470.94
76_H81_P0.5460.94
68_S154_Q0.5450.94
7_D181_R0.5440.94
48_V54_G0.5440.94
58_D160_P0.5420.93
110_G116_Y0.5420.93
149_R153_K0.5400.93
63_Y70_M0.5360.93
131_D149_R0.5350.93
42_R115_S0.5310.93
28_G31_Y0.5300.93
106_V160_P0.5260.92
75_R79_N0.5230.92
150_K154_Q0.5180.92
138_R141_R0.5170.92
5_H8_N0.5170.92
139_D142_D0.5160.92
21_R31_Y0.5150.92
171_I194_P0.5150.92
195_P201_D0.5100.91
103_L159_V0.5090.91
48_V52_P0.5070.91
48_V59_Y0.5040.91
95_I167_L0.5030.91
137_A140_W0.5020.91
38_E42_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wfxA 3 0.4314 81.7 0.901 Contact Map
4m5rA 2 0.1912 3.3 0.955 Contact Map
1brvA 1 0.0931 2.4 0.958 Contact Map
2o0qA 1 0.5441 2.1 0.96 Contact Map
4gelA 2 0.2745 1.8 0.961 Contact Map
1v0wA 1 0.4069 1.7 0.962 Contact Map
4zrlB 1 0.1814 1.4 0.963 Contact Map
2ejbA 6 0.25 1.3 0.964 Contact Map
3u4zA 2 0.2647 1.2 0.965 Contact Map
5aj3R 1 0.3235 1.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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