GREMLIN Database
FISNA - Fish-specific NACHT associated domain
PFAM: PF14484 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (72)
Sequences: 1016 (553)
Seq/√Len: 65.2
META: 0.079

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_G42_V3.0971.00
6_K37_G2.9421.00
13_F17_A2.6531.00
69_D72_K2.5301.00
58_P61_Q2.1421.00
59_D63_T2.0451.00
3_S7_K1.8731.00
25_L29_Y1.7861.00
13_F21_N1.7551.00
9_F68_E1.6370.99
52_E55_S1.6330.99
23_T26_N1.5900.99
7_K10_Q1.5500.99
57_K64_P1.5120.99
64_P68_E1.4670.98
10_Q27_Q1.4590.98
18_K22_P1.4520.98
15_G28_I1.4350.98
63_T70_I1.4100.98
8_K43_N1.4080.98
60_R68_E1.4030.98
21_N38_G1.3480.97
61_Q64_P1.3360.97
12_V49_R1.3180.97
19_A66_K1.3010.96
13_F16_I1.3010.96
30_T37_G1.2930.96
13_F22_P1.2830.96
59_D62_E1.2720.96
4_S70_I1.1520.93
31_E49_R1.1410.93
28_I40_G1.1370.93
27_Q40_G1.1010.91
18_K38_G1.0970.91
60_R67_C1.0960.91
2_K6_K1.0920.91
54_A58_P1.0770.90
39_S47_E1.0610.90
10_Q24_L1.0530.89
11_C22_P1.0440.89
21_N36_E1.0050.87
19_A37_G0.9670.85
15_G46_H0.9570.84
65_I69_D0.9520.84
57_K60_R0.9450.84
21_N65_I0.9380.83
1_L53_T0.9360.83
16_I29_Y0.8990.80
16_I20_G0.8780.79
67_C70_I0.8770.79
15_G25_L0.8710.78
34_I41_E0.8640.78
38_G70_I0.8630.78
15_G20_G0.8350.75
31_E53_T0.8160.74
55_S63_T0.8160.74
1_L62_E0.8150.74
53_T56_R0.7990.72
3_S24_L0.7920.71
5_L38_G0.7890.71
2_K67_C0.7740.70
8_K35_T0.7690.69
16_I61_Q0.7580.68
25_L30_T0.7330.65
8_K21_N0.7220.64
66_K69_D0.7080.63
1_L15_G0.7070.63
39_S44_N0.7030.62
54_A57_K0.6940.61
57_K62_E0.6800.60
10_Q67_C0.6800.60
22_P47_E0.6770.59
15_G30_T0.6760.59
5_L31_E0.6760.59
29_Y58_P0.6640.58
39_S67_C0.6520.56
12_V59_D0.6440.56
2_K58_P0.6310.54
46_H69_D0.6260.53
40_G71_F0.6210.53
39_S63_T0.6160.52
3_S17_A0.6060.51
39_S43_N0.5950.50
33_Y38_G0.5930.50
6_K45_E0.5930.50
28_I38_G0.5920.49
31_E66_K0.5920.49
37_G43_N0.5730.47
53_T60_R0.5660.46
44_N53_T0.5630.46
12_V44_N0.5510.45
15_G37_G0.5430.44
45_E49_R0.5410.44
47_E52_E0.5380.43
13_F20_G0.5380.43
15_G50_Q0.5350.43
24_L33_Y0.5340.43
61_Q67_C0.5290.42
33_Y72_K0.5230.41
19_A22_P0.5230.41
16_I19_A0.5220.41
19_A68_E0.5130.40
56_R66_K0.5110.40
36_E48_V0.5100.40
23_T32_L0.5060.40
18_K45_E0.5050.39
7_K27_Q0.5030.39
50_Q70_I0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kxfK 4 0.75 45.7 0.84 Contact Map
3nuhB 1 0.5833 7.2 0.891 Contact Map
2xcsB 2 0.7083 4.6 0.901 Contact Map
3k9fC 1 0.6806 3.6 0.905 Contact Map
1fioA 1 0.7917 3.5 0.906 Contact Map
3c65A 1 0.75 3 0.909 Contact Map
2xkjE 2 0.8611 3 0.909 Contact Map
4gfhA 2 0.8472 2.8 0.911 Contact Map
2nrrA 1 0.6944 2.6 0.912 Contact Map
3l4jA 1 0.8889 2.5 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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