GREMLIN Database
DUF4428 - Domain of unknown function (DUF4428)
PFAM: PF14471 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (48)
Sequences: 632 (412)
Seq/√Len: 59.4
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_E25_D2.9241.00
46_E50_E2.6931.00
4_I22_L2.6101.00
30_L48_I2.2301.00
2_C5_C2.1171.00
14_N21_N2.0031.00
18_E39_R1.7910.99
46_E49_K1.7400.99
45_V49_K1.7020.99
34_F43_S1.6250.99
47_E50_E1.5440.98
30_L43_S1.5090.98
15_R37_R1.4410.97
15_R27_A1.3780.97
3_D20_G1.3350.96
3_D45_V1.3280.96
15_R24_K1.1800.92
6_G36_D1.1660.92
9_I20_G1.1160.90
17_L22_L1.0660.88
21_N24_K1.0630.88
31_S35_S1.0110.85
9_I14_N0.9840.83
30_L33_F0.9680.82
28_K39_R0.9590.82
32_P43_S0.9560.81
27_A37_R0.9420.80
28_K36_D0.9340.80
3_D21_N0.9030.77
17_L23_C0.9020.77
14_N22_L0.8910.77
14_N17_L0.8300.71
9_I21_N0.8260.71
35_S39_R0.8180.70
9_I13_G0.8040.69
12_L24_K0.7940.68
13_G32_P0.7740.66
3_D10_G0.7690.65
30_L34_F0.7600.64
12_L16_K0.7580.64
7_E10_G0.7540.64
43_S48_I0.7430.63
18_E42_Q0.7400.62
5_C26_C0.7320.62
35_S49_K0.7270.61
3_D48_I0.7190.60
17_L43_S0.6830.56
4_I49_K0.6830.56
18_E50_E0.6810.56
7_E29_K0.6680.55
1_N12_L0.6630.54
44_T47_E0.6600.54
9_I12_L0.6470.52
5_C23_C0.6450.52
36_D47_E0.6410.52
11_L27_A0.6330.51
14_N20_G0.6120.48
11_L24_K0.5870.46
2_C26_C0.5790.45
10_G35_S0.5780.45
43_S46_E0.5740.44
13_G48_I0.5720.44
9_I24_K0.5670.43
38_R42_Q0.5660.43
13_G20_G0.5540.42
10_G13_G0.5520.42
4_I24_K0.5400.40
8_K11_L0.5370.40
36_D43_S0.5140.38
23_C26_C0.5040.37
19_D45_V0.5020.36
2_C23_C0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 1 72.2 0.703 Contact Map
2gviA 3 0.549 72.1 0.703 Contact Map
1ovxA 2 0.6863 71.5 0.705 Contact Map
2ds5A 2 0.7451 71.2 0.705 Contact Map
3d00A 2 0.5294 67.6 0.713 Contact Map
3avrA 1 1 47.9 0.745 Contact Map
4uf0A 2 1 47.5 0.746 Contact Map
4dduA 1 0.902 44.5 0.751 Contact Map
1y02A 1 0.902 43.5 0.752 Contact Map
2fiyA 1 0.9804 36.8 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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