GREMLIN Database
PT-TG - Pre-toxin TG
PFAM: PF14449 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (72)
Sequences: 740 (592)
Seq/√Len: 69.7
META: 0.63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S29_D3.6161.00
10_D19_K3.4321.00
37_S40_D2.6481.00
10_D20_D2.3191.00
36_L40_D2.3121.00
19_K23_E2.2731.00
13_P16_G1.9881.00
6_S19_K1.8701.00
24_A41_R1.8441.00
36_L41_R1.6931.00
20_D23_E1.6731.00
29_D32_T1.6050.99
38_T42_A1.6030.99
59_G63_K1.5440.99
23_E30_P1.5390.99
38_T41_R1.5320.99
12_I15_V1.4010.98
47_G50_A1.2920.97
34_E40_D1.2760.97
24_A48_A1.2160.96
71_A75_A1.1620.94
9_L19_K1.1560.94
68_G72_A1.1500.94
15_V35_K1.1410.94
24_A36_L1.1310.94
70_K73_K1.0920.92
19_K29_D1.0910.92
23_E44_A1.0770.92
9_L12_I1.0480.91
49_L53_I1.0370.90
71_A74_A1.0360.90
14_E23_E1.0120.89
17_G20_D1.0070.89
44_A47_G1.0030.89
65_G69_A0.9990.89
50_A53_I0.9980.89
47_G54_P0.9920.88
20_D41_R0.9790.88
23_E36_L0.9760.87
41_R45_G0.9750.87
14_E18_V0.9580.86
39_W42_A0.9480.86
62_G65_G0.9460.86
50_A54_P0.9240.84
24_A27_G0.9180.84
72_A75_A0.9030.83
28_K32_T0.8790.81
69_A74_A0.8670.80
28_K35_K0.8560.80
47_G52_L0.8560.80
45_G64_K0.8530.79
59_G62_G0.8360.78
17_G51_G0.8340.78
41_R44_A0.8280.77
11_F70_K0.8200.77
15_V19_K0.8200.77
68_G73_K0.8180.76
6_S10_D0.8050.75
55_V61_A0.7930.74
62_G66_K0.7870.74
13_P19_K0.7860.73
55_V59_G0.7850.73
42_A45_G0.7780.73
42_A46_V0.7710.72
34_E46_V0.7700.72
22_Y26_T0.7670.72
20_D44_A0.7630.71
65_G68_G0.7630.71
10_D13_P0.7620.71
16_G19_K0.7320.68
31_I69_A0.7200.67
4_L62_G0.7180.67
18_V22_Y0.7080.66
13_P23_E0.7050.65
59_G65_G0.7040.65
61_A73_K0.7040.65
20_D24_A0.6980.64
5_L12_I0.6920.64
56_G60_K0.6600.60
4_L8_A0.6580.60
9_L23_E0.6570.60
6_S20_D0.6560.60
21_A26_T0.6560.60
6_S16_G0.6500.59
56_G59_G0.6450.58
22_Y30_P0.6410.58
64_K68_G0.6410.58
46_V50_A0.6380.57
17_G52_L0.6320.57
39_W43_L0.6290.56
29_D34_E0.6190.55
20_D48_A0.6010.53
20_D47_G0.5900.52
6_S32_T0.5880.51
48_A51_G0.5740.50
65_G71_A0.5720.50
64_K67_K0.5670.49
7_L11_F0.5600.48
19_K30_P0.5520.47
6_S15_V0.5490.47
16_G51_G0.5430.46
33_G45_G0.5340.45
40_D43_L0.5220.44
48_A52_L0.5210.43
21_A25_I0.5170.43
19_K26_T0.5090.42
12_I19_K0.5080.42
69_A73_K0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1gA 2 1 5.1 0.883 Contact Map
1g62A 1 0.557 5.1 0.883 Contact Map
2np2A 2 0.7595 4.5 0.887 Contact Map
1exeA 2 0.8354 3.9 0.89 Contact Map
2mluA 1 0.3418 3.7 0.891 Contact Map
1g61A 1 0.5443 3.6 0.891 Contact Map
4n1vA 2 0.7089 3.5 0.893 Contact Map
4pt4A 2 0.8354 3.2 0.894 Contact Map
1p71A 2 0.7722 3 0.896 Contact Map
1owfA 1 0.7848 2.7 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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