GREMLIN Database
OTT_1508_deam - OTT_1508-like deaminase
PFAM: PF14441 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (64)
Sequences: 1149 (1013)
Seq/√Len: 126.7
META: 0.561

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_Y51_R3.5141.00
33_L57_L3.0441.00
7_L38_I2.9831.00
29_L52_G2.7891.00
4_I37_F2.4021.00
30_C52_G2.3511.00
35_H53_S2.3411.00
25_G51_R2.1721.00
9_H13_N2.0841.00
26_V30_C1.9291.00
30_C50_V1.8191.00
35_H39_R1.6281.00
61_W64_P1.5241.00
54_H58_Y1.4781.00
38_I50_V1.4581.00
59_P62_R1.4391.00
28_K54_H1.4141.00
36_L53_S1.4011.00
15_R18_K1.3891.00
32_Y57_L1.3801.00
8_L12_K1.3401.00
32_Y36_L1.3211.00
2_A54_H1.3021.00
23_Y29_L1.1870.99
42_H45_G1.1360.99
33_L58_Y1.0630.99
13_N17_L1.0550.98
40_A46_Y1.0390.98
16_P19_F0.9820.98
40_A48_I0.9800.97
40_A43_G0.9730.97
4_I38_I0.9270.96
17_L20_L0.9240.96
25_G35_H0.9220.96
4_I8_L0.9040.96
33_L61_W0.8800.95
33_L37_F0.8750.95
41_L44_K0.8660.95
46_Y49_K0.8550.94
42_H46_Y0.8420.94
10_L14_P0.7970.92
32_Y37_F0.7950.92
23_Y26_V0.7680.91
23_Y52_G0.7660.91
31_C34_C0.7640.90
26_V50_V0.7630.90
2_A51_R0.7580.90
13_N44_K0.7460.89
57_L62_R0.7410.89
12_K55_G0.7290.88
37_F48_I0.7270.88
13_N18_K0.7180.88
37_F56_K0.7120.87
13_N16_P0.7090.87
17_L21_P0.7010.86
42_H47_E0.6840.85
12_K47_E0.6820.85
8_L11_E0.6790.84
18_K21_P0.6690.84
7_L25_G0.6590.83
9_H27_S0.6590.83
4_I61_W0.6480.82
9_H20_L0.6430.81
5_Q8_L0.6350.80
24_I50_V0.6260.79
6_L33_L0.6210.79
26_V52_G0.6180.79
43_G47_E0.6160.78
50_V60_N0.6140.78
40_A44_K0.6080.77
41_L46_Y0.6070.77
26_V38_I0.6020.77
2_A58_Y0.6010.77
53_S56_K0.6000.76
44_K48_I0.6000.76
30_C53_S0.5930.76
36_L39_R0.5820.74
25_G63_L0.5810.74
8_L63_L0.5660.72
43_G46_Y0.5570.71
9_H15_R0.5520.70
8_L29_L0.5500.70
13_N21_P0.5450.69
11_E59_P0.5360.68
5_Q11_E0.5300.67
24_I37_F0.5290.67
7_L37_F0.5200.66
29_L50_V0.5190.66
27_S38_I0.5180.66
27_S56_K0.5150.65
52_G60_N0.5140.65
42_H49_K0.5040.63
52_G55_G0.5030.63
30_C33_L0.5030.63
35_H55_G0.5020.63
29_L35_H0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mzzA 1 0.9846 88.2 0.738 Contact Map
4j4jA 1 0.9846 87.9 0.74 Contact Map
3v4kA 3 0.9692 87 0.743 Contact Map
3vowA 1 0.9846 87 0.743 Contact Map
4xxoA 2 0.9692 80.1 0.764 Contact Map
2nytA 3 0.9692 77.5 0.77 Contact Map
4p9cA 5 0.8 61.9 0.794 Contact Map
1vq2A 3 0.9385 57.1 0.8 Contact Map
1wwrA 3 1 57.1 0.8 Contact Map
4eg2A 4 0.9538 55.6 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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