GREMLIN Database
DYW_deaminase - DYW family of nucleic acid deaminases
PFAM: PF14432 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (125)
Sequences: 4371 (2606)
Seq/√Len: 233.1
META: 0.094

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_I104_I5.5831.00
114_E127_K4.1411.00
24_Q81_S3.6401.00
50_F98_G3.3021.00
103_A107_I3.2541.00
24_Q27_E3.1571.00
31_K34_E3.1151.00
6_I78_G2.7621.00
25_S29_Y2.6171.00
35_L111_T2.6061.00
4_S90_I2.3071.00
104_I117_V2.0461.00
39_L103_A1.9271.00
96_V117_V1.9211.00
42_A109_K1.8931.00
75_I90_I1.8791.00
40_K61_E1.8031.00
39_L110_I1.7061.00
31_K80_I1.6751.00
13_H22_H1.6351.00
3_C14_E1.5771.00
38_K41_E1.5761.00
75_I107_I1.5731.00
96_V104_I1.5081.00
47_D98_G1.4881.00
3_C16_V1.4361.00
34_E38_K1.4271.00
36_S72_K1.3891.00
39_L106_L1.3731.00
82_T86_T1.3571.00
82_T88_I1.3431.00
82_T113_R1.3271.00
22_H28_I1.3231.00
36_S67_S1.2771.00
20_R29_Y1.2721.00
55_V65_A1.2621.00
29_Y73_L1.2391.00
89_R116_I1.2341.00
36_S39_L1.2011.00
8_V81_S1.1781.00
42_A110_I1.1601.00
21_S25_S1.1601.00
50_F53_H1.1241.00
38_K111_T1.1221.00
13_H77_F1.1101.00
39_L107_I1.0951.00
116_I125_H1.0921.00
24_Q77_F1.0901.00
78_G88_I1.0571.00
37_E41_E1.0381.00
14_E91_V1.0341.00
31_K111_T1.0321.00
97_C100_C1.0301.00
26_E30_A1.0281.00
65_A120_R1.0171.00
5_W91_V1.0111.00
9_K81_S1.0001.00
44_Y99_D0.9931.00
102_S106_L0.9871.00
27_E30_A0.9811.00
8_V82_T0.9801.00
79_L107_I0.9731.00
18_G68_Y0.9731.00
83_P86_T0.9661.00
38_K42_A0.9551.00
69_H100_C0.9481.00
47_D102_S0.9371.00
54_D60_K0.9241.00
82_T85_G0.9211.00
25_S73_L0.9201.00
5_W14_E0.9191.00
48_T72_K0.9141.00
71_E94_L0.9071.00
87_P116_I0.9041.00
31_K76_A0.8970.99
65_A68_Y0.8950.99
32_L76_A0.8880.99
44_Y102_S0.8850.99
87_P114_E0.8740.99
51_V55_V0.8680.99
2_G94_L0.8670.99
14_E120_R0.8650.99
51_V66_L0.8610.99
39_L111_T0.8540.99
35_L76_A0.8520.99
5_W83_P0.8370.99
82_T87_P0.8360.99
19_D70_S0.8300.99
10_G53_H0.8290.99
48_T51_V0.8250.99
35_L107_I0.8200.99
8_V77_F0.8000.99
31_K79_L0.7890.99
48_T57_E0.7750.98
48_T60_K0.7670.98
118_R122_R0.7660.98
42_A106_L0.7570.98
9_K83_P0.7540.98
79_L111_T0.7470.98
77_F81_S0.7430.98
55_V60_K0.7400.98
51_V60_K0.7370.98
118_R123_F0.7310.98
31_K38_K0.7310.98
104_I107_I0.7270.98
11_K14_E0.7250.98
20_R25_S0.7250.98
114_E125_H0.7150.97
20_R26_E0.7110.97
98_G102_S0.6970.97
32_L103_A0.6930.97
4_S104_I0.6870.97
15_F77_F0.6850.97
28_I31_K0.6790.97
2_G93_N0.6710.96
33_E37_E0.6660.96
8_V121_N0.6490.96
111_T120_R0.6450.95
37_E112_G0.6400.95
29_Y68_Y0.6350.95
47_D50_F0.6350.95
91_V123_F0.6340.95
75_I96_V0.6340.95
50_F66_L0.6330.95
32_L39_L0.6300.95
72_K99_D0.6290.95
71_E92_K0.6280.95
35_L103_A0.6220.94
67_S121_N0.6190.94
52_L56_E0.6170.94
56_E59_E0.6150.94
55_V59_E0.6070.94
83_P87_P0.6010.93
46_P51_V0.5990.93
27_E88_I0.5930.93
30_A37_E0.5890.93
28_I32_L0.5880.93
53_H66_L0.5870.92
57_E60_K0.5850.92
52_L55_V0.5850.92
95_R122_R0.5830.92
94_L122_R0.5800.92
14_E18_G0.5770.92
107_I111_T0.5750.92
72_K104_I0.5740.92
26_E108_S0.5710.91
5_W121_N0.5690.91
20_R33_E0.5690.91
48_T53_H0.5690.91
7_E12_V0.5670.91
79_L86_T0.5660.91
36_S110_I0.5660.91
10_G98_G0.5630.91
29_Y33_E0.5630.91
101_H124_H0.5610.91
32_L73_L0.5610.91
31_K121_N0.5570.90
66_L72_K0.5550.90
103_A106_L0.5530.90
70_S123_F0.5460.90
94_L99_D0.5430.89
5_W89_R0.5410.89
84_P112_G0.5360.89
70_S74_A0.5350.89
51_V122_R0.5300.88
101_H105_K0.5260.88
73_L90_I0.5220.87
59_E62_E0.5210.87
71_E122_R0.5180.87
101_H108_S0.5170.87
32_L36_S0.5160.87
5_W9_K0.5160.87
16_V65_A0.5140.87
11_K120_R0.5140.87
16_V91_V0.5130.86
41_E47_D0.5130.86
10_G13_H0.5120.86
20_R62_E0.5110.86
35_L79_L0.5090.86
103_A110_I0.5080.86
35_L50_F0.5080.86
33_E68_Y0.5050.86
14_E21_S0.5050.86
17_A62_E0.5040.85
109_K112_G0.5030.85
24_Q121_N0.5030.85
17_A36_S0.5030.85
26_E33_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b89A 1 0.4409 19.8 0.932 Contact Map
3rmtA 4 0.9449 14.5 0.936 Contact Map
3slhA 4 0.9606 11.7 0.939 Contact Map
2waoA 1 0.3622 8.4 0.942 Contact Map
1dvpA 2 0.7874 7.8 0.943 Contact Map
1pm4A 3 0.315 7.7 0.943 Contact Map
16pkA 1 0.8976 6.9 0.945 Contact Map
2jtnA 1 0.685 6.6 0.945 Contact Map
2fr5A 6 0.7795 6.5 0.945 Contact Map
1t3bA 2 0.7874 6.3 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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