GREMLIN Database
Imm1 - Immunity protein Imm1
PFAM: PF14430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (115)
Sequences: 1487 (1357)
Seq/√Len: 126.5
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_D110_R3.9291.00
60_A105_A3.0381.00
111_E120_P2.8571.00
22_D106_L2.7111.00
17_T20_E2.5881.00
26_D106_L2.4791.00
72_Y75_G2.4581.00
101_P104_T2.2931.00
71_F75_G2.2711.00
70_G74_V2.2211.00
111_E119_P2.1651.00
97_R125_E2.0821.00
70_G75_G2.0581.00
85_F88_G1.9371.00
73_S76_G1.8341.00
111_E115_T1.7711.00
18_W110_R1.7711.00
71_F74_V1.7541.00
108_A122_V1.7411.00
61_V94_F1.7211.00
37_V41_L1.6441.00
22_D26_D1.6271.00
111_E121_S1.5471.00
15_V21_L1.5461.00
18_W113_F1.5091.00
100_V105_A1.4991.00
18_W114_E1.4641.00
104_T107_R1.3961.00
83_V89_G1.3591.00
62_L108_A1.3361.00
16_A20_E1.2831.00
95_P98_W1.2791.00
49_P53_I1.2641.00
21_L25_L1.2150.99
102_L106_L1.2140.99
70_G73_S1.2120.99
21_L28_L1.1990.99
59_Y99_V1.1940.99
18_W21_L1.1810.99
49_P54_G1.1770.99
72_Y76_G1.1620.99
63_L66_D1.1520.99
72_Y77_P1.1420.99
119_P122_V1.1390.99
83_V87_L1.1340.99
21_L113_F1.1280.99
76_G79_A1.1250.99
106_L110_R1.1210.99
85_F99_V1.1040.99
71_F76_G1.0820.99
110_R114_E1.0760.99
107_R119_P1.0730.99
25_L102_L1.0660.99
117_E120_P1.0650.99
18_W22_D1.0460.98
84_E91_G1.0420.98
87_L91_G1.0140.98
45_P103_E1.0110.98
75_G79_A1.0100.98
90_G93_E1.0080.98
82_E93_E0.9870.98
57_G60_A0.9660.97
37_V40_W0.9640.97
87_L90_G0.9600.97
88_G91_G0.9600.97
15_V18_W0.9540.97
85_F90_G0.9460.97
100_V122_V0.9460.97
67_D70_G0.9430.97
49_P55_V0.9370.97
29_D32_A0.9260.96
87_L92_T0.9240.96
88_G92_T0.9230.96
34_P37_V0.8940.96
96_A99_V0.8910.96
104_T122_V0.8870.95
41_L45_P0.8730.95
13_V27_R0.8720.95
64_Y68_D0.8580.95
99_V105_A0.8570.95
74_V122_V0.8570.95
53_I62_L0.8450.94
37_V43_G0.8450.94
107_R110_R0.8420.94
53_I105_A0.8350.94
41_L112_F0.8320.94
49_P52_G0.8200.93
52_G61_V0.8090.93
100_V108_A0.8080.93
51_L109_A0.8050.93
48_G53_I0.8010.92
89_G94_F0.8000.92
38_E89_G0.8000.92
15_V24_A0.7990.92
89_G92_T0.7900.92
56_G60_A0.7790.91
51_L55_V0.7720.91
86_D89_G0.7690.91
106_L109_A0.7670.91
77_P123_E0.7620.90
21_L109_A0.7560.90
20_E23_A0.7550.90
70_G78_D0.7410.89
30_G34_P0.7270.88
34_P55_V0.7240.88
115_T120_P0.7190.88
113_F126_E0.6980.86
40_W54_G0.6900.85
50_S53_I0.6810.85
56_G61_V0.6780.84
23_A27_R0.6740.84
115_T118_R0.6710.84
52_G55_V0.6650.83
55_V60_A0.6610.83
118_R124_W0.6550.82
86_D91_G0.6540.82
83_V99_V0.6510.82
38_E43_G0.6440.81
54_G61_V0.6410.81
48_G56_G0.6340.80
73_S78_D0.6340.80
86_D90_G0.6320.80
49_P56_G0.6260.79
77_P80_P0.6220.79
72_Y118_R0.6220.79
64_Y67_D0.6190.79
108_A121_S0.6160.78
115_T121_S0.6150.78
73_S77_P0.6140.78
116_G120_P0.6110.78
39_L109_A0.6070.77
49_P66_D0.5960.76
83_V96_A0.5940.76
27_R30_G0.5920.75
11_E14_E0.5860.75
15_V20_E0.5860.75
106_L113_F0.5810.74
111_E117_E0.5780.74
43_G46_E0.5740.73
44_D48_G0.5730.73
87_L94_F0.5730.73
60_A64_Y0.5680.72
33_R112_F0.5630.72
29_D34_P0.5610.72
34_P41_L0.5600.71
42_S112_F0.5580.71
37_V99_V0.5510.70
49_P62_L0.5490.70
21_L29_D0.5460.69
107_R121_S0.5460.69
87_L93_E0.5440.69
107_R114_E0.5430.69
59_Y101_P0.5420.69
28_L32_A0.5400.69
26_D46_E0.5370.68
53_I109_A0.5370.68
84_E88_G0.5350.68
91_G94_F0.5340.68
56_G59_Y0.5320.68
62_L65_F0.5320.68
52_G63_L0.5310.67
105_A126_E0.5210.66
40_W50_S0.5150.65
114_E123_E0.5120.65
14_E20_E0.5110.64
94_F108_A0.5090.64
29_D106_L0.5060.64
11_E15_V0.5040.63
70_G76_G0.5040.63
36_L87_L0.5020.63
48_G52_G0.5020.63
61_V105_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q6zA 4 0.3386 13.3 0.892 Contact Map
2ktrA 2 0.315 11 0.896 Contact Map
4mjsB 1 0.315 10.9 0.897 Contact Map
2ihtA 4 0.4331 9.3 0.9 Contact Map
1q1oA 1 0.3228 8.7 0.901 Contact Map
2uz1A 4 0.4094 8.6 0.901 Contact Map
1wj6A 1 0.378 8.6 0.901 Contact Map
1vd2A 1 0.3386 8.5 0.901 Contact Map
2bkfA 1 0.3307 8.3 0.902 Contact Map
1pqsA 1 0.3228 8.1 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.