GREMLIN Database
Clr5 - Clr5 domain
PFAM: PF14420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 1178 (1012)
Seq/√Len: 140.3
META: 0.281

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_R18_E2.7111.00
12_T51_F2.6091.00
39_E43_K2.3561.00
11_I46_L2.2161.00
45_R48_K2.0821.00
7_H11_I1.8681.00
30_E36_K1.8581.00
27_E31_E1.7811.00
28_I32_E1.7201.00
20_K24_E1.7051.00
14_L25_V1.6751.00
8_K12_T1.6071.00
13_R17_D1.5731.00
29_M42_Y1.5051.00
12_T16_I1.3651.00
40_R44_R1.3441.00
7_H10_I1.3431.00
37_A42_Y1.2891.00
10_I32_E1.2651.00
26_M39_E1.2651.00
20_K28_I1.2251.00
46_L51_F1.1640.99
3_D6_A1.1210.99
29_M46_L1.0660.99
14_L28_I1.0450.99
46_L52_R1.0280.99
5_E8_K1.0220.99
26_M30_E1.0130.99
41_Q45_R1.0060.98
10_I33_H0.9930.98
8_K51_F0.9870.98
10_I13_R0.9290.97
29_M37_A0.8950.97
22_L42_Y0.8890.97
16_I51_F0.8820.97
12_T17_D0.8710.96
23_K39_E0.8700.96
21_T24_E0.8580.96
2_E41_Q0.8520.96
4_W37_A0.8400.95
24_E27_E0.8140.95
20_K25_V0.7570.92
41_Q44_R0.7540.92
15_Y53_K0.7530.92
10_I14_L0.7370.91
26_M29_M0.7170.90
9_P12_T0.7130.90
40_R43_K0.7070.89
7_H29_M0.6960.89
21_T47_K0.6750.87
19_N48_K0.6730.87
21_T25_V0.6720.87
42_Y46_L0.6460.85
11_I29_M0.6340.84
29_M33_H0.6250.83
11_I42_Y0.6170.82
15_Y22_L0.6130.81
24_E36_K0.6070.81
38_S41_Q0.6070.81
44_R47_K0.6010.80
22_L25_V0.5980.80
6_A36_K0.5830.78
15_Y45_R0.5670.76
35_F41_Q0.5650.76
10_I28_I0.5570.75
21_T32_E0.5560.75
11_I25_V0.5540.75
9_P13_R0.5390.73
2_E17_D0.5340.72
21_T41_Q0.5290.71
9_P34_G0.5230.70
12_T15_Y0.5180.70
27_E48_K0.5160.69
25_V42_Y0.5140.69
4_W53_K0.5130.69
40_R47_K0.5110.69
3_D7_H0.5100.68
22_L26_M0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k78A 1 0.9245 68.8 0.749 Contact Map
2k27A 1 0.9811 51.3 0.774 Contact Map
3lapA 6 0.9057 35.4 0.796 Contact Map
1pdnC 1 0.8491 30.2 0.803 Contact Map
2ahqA 1 0.9245 29.5 0.804 Contact Map
3v4gA 5 0.9245 28.7 0.804 Contact Map
1b4aA 5 0.9057 27 0.808 Contact Map
1u78A 1 0.8679 25.3 0.81 Contact Map
4fcyA 4 0.9811 20.7 0.818 Contact Map
4trbA 2 1 15.3 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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