GREMLIN Database
PMR5N - PMR5 N terminal Domain
PFAM: PF14416 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 1978 (872)
Seq/√Len: 121.0
META: 0.086

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_K50_D2.9261.00
7_D50_D2.9061.00
27_D30_F2.7161.00
48_Q53_D2.6211.00
31_N34_K2.1941.00
33_Q43_L2.1261.00
19_T22_S1.9881.00
39_D42_Y1.8151.00
13_D46_R1.5051.00
4_D7_D1.4391.00
31_N43_L1.3641.00
28_E35_N1.3401.00
12_Y41_D1.3391.00
14_E44_K1.3221.00
28_E34_K1.3051.00
33_Q42_Y1.2420.99
41_D44_K1.2160.99
18_Y23_C1.2000.99
29_Q35_N1.1850.99
13_D16_P1.1720.99
27_D35_N1.1100.99
26_I29_Q1.0890.99
15_Y44_K1.0810.98
37_R40_S1.0640.98
37_R42_Y1.0620.98
9_K24_P1.0530.98
21_S28_E1.0220.98
11_V48_Q1.0000.97
16_P38_P0.9870.97
26_I31_N0.9800.97
12_Y34_K0.9670.97
46_R49_P0.9550.97
25_F35_N0.9520.97
29_Q45_W0.9510.97
26_I30_F0.8720.94
24_P33_Q0.8650.94
2_G50_D0.8600.94
10_W23_C0.8430.93
36_G42_Y0.8420.93
15_Y30_F0.7990.91
13_D17_L0.7920.91
5_L27_D0.7900.91
49_P52_C0.7780.90
7_D51_G0.7440.88
25_F29_Q0.7410.88
20_N43_L0.7300.87
9_K33_Q0.7180.86
47_W52_C0.7140.86
17_L42_Y0.7110.86
23_C32_C0.7080.85
2_G13_D0.6890.84
34_K45_W0.6810.83
12_Y48_Q0.6760.83
2_G51_G0.6720.82
36_G39_D0.6720.82
9_K48_Q0.6520.80
2_G14_E0.6330.79
10_W18_Y0.6240.78
25_F30_F0.6210.77
5_L20_N0.6150.77
41_D45_W0.6100.76
30_F45_W0.6060.75
26_I34_K0.5930.74
46_R53_D0.5850.73
36_G45_W0.5680.71
2_G6_F0.5580.69
20_N31_N0.5570.69
6_F27_D0.5550.69
17_L37_R0.5450.68
20_N30_F0.5270.65
17_L44_K0.5220.64
20_N34_K0.5130.63
15_Y46_R0.5110.63
45_W50_D0.5070.62
5_L17_L0.5050.62
2_G12_Y0.5020.61
24_P28_E0.5010.61
19_T33_Q0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dadA 1 0.7358 4.4 0.903 Contact Map
3cw3A 1 0.7736 3.2 0.909 Contact Map
2mi5A 1 0.6415 2.5 0.915 Contact Map
1zwmA 1 0.7736 1.8 0.92 Contact Map
3pjxA 1 0.3396 1.8 0.92 Contact Map
1u5mA 1 0.5472 1.8 0.92 Contact Map
1fjrA 1 1 1.7 0.922 Contact Map
1h4aX 1 0.7925 1.5 0.924 Contact Map
4pfbA 1 0 1.5 0.924 Contact Map
1ytqA 4 0.8679 1.4 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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