GREMLIN Database
AHH - A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
PFAM: PF14412 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (100)
Sequences: 2705 (2416)
Seq/√Len: 241.6
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_A50_G3.8351.00
91_R95_L3.4241.00
79_R104_E2.7651.00
79_R97_E2.6601.00
24_G45_N2.5551.00
23_P73_H2.5321.00
75_A79_R2.0551.00
90_A93_A2.0321.00
26_N29_R2.0001.00
17_Q65_R1.9141.00
32_R77_N1.8811.00
45_N50_G1.8131.00
16_Y52_F1.7681.00
97_E100_K1.7611.00
26_N73_H1.7371.00
18_A52_F1.7081.00
99_R102_R1.6461.00
53_L64_H1.6201.00
31_P35_E1.6191.00
48_A95_L1.5761.00
102_R106_R1.5311.00
33_A37_L1.4831.00
24_G44_I1.4791.00
87_P90_A1.4701.00
43_D46_D1.4681.00
12_P16_Y1.4071.00
33_A36_I1.4071.00
70_N74_E1.3531.00
17_Q55_R1.3361.00
25_K73_H1.3301.00
40_A85_K1.3101.00
74_E78_E1.2771.00
21_I51_V1.2661.00
30_A34_R1.2631.00
27_K30_A1.2441.00
34_R38_K1.2421.00
23_P26_N1.2351.00
34_R37_L1.2061.00
77_N81_D1.1931.00
24_G50_G1.1211.00
36_I77_N1.1061.00
40_A94_L1.1051.00
22_V37_L1.1021.00
89_G93_A1.1021.00
22_V33_A1.0951.00
21_I102_R1.0551.00
93_A96_E1.0531.00
32_R81_D1.0531.00
93_A97_E1.0501.00
103_E107_N1.0411.00
35_E39_K1.0401.00
39_K84_D1.0381.00
19_H67_P1.0371.00
86_S89_G1.0101.00
75_A78_E0.9961.00
36_I94_L0.9471.00
94_L102_R0.9411.00
90_A94_L0.9321.00
33_A77_N0.9291.00
72_Y76_V0.9231.00
92_E95_L0.9211.00
7_A12_P0.9121.00
79_R82_K0.8901.00
9_G12_P0.8881.00
37_L42_I0.8881.00
29_R70_N0.8850.99
29_R74_E0.8740.99
67_P73_H0.8690.99
53_L105_L0.8580.99
25_K67_P0.8530.99
42_I46_D0.8520.99
11_R52_F0.8480.99
37_L40_A0.8400.99
92_E96_E0.8320.99
86_S90_A0.8300.99
76_V105_L0.8250.99
51_V106_R0.8210.99
11_R16_Y0.8120.99
103_E106_R0.8100.99
48_A91_R0.8010.99
48_A99_R0.8010.99
19_H51_V0.7850.99
19_H72_Y0.7790.99
95_L99_R0.7680.99
73_H77_N0.7640.99
72_Y105_L0.7580.98
83_A97_E0.7530.98
37_L94_L0.7500.98
16_Y54_P0.7480.98
15_G55_R0.7430.98
34_R44_I0.7190.98
23_P76_V0.7180.98
23_P30_A0.7150.98
57_E66_G0.7150.98
53_L62_P0.7070.98
11_R14_P0.6990.97
104_E107_N0.6910.97
30_A36_I0.6840.97
23_P72_Y0.6800.97
55_R60_G0.6740.97
28_P31_P0.6710.97
98_L102_R0.6620.96
30_A73_H0.6610.96
47_A50_G0.6580.96
17_Q66_G0.6560.96
38_K43_D0.6420.96
12_P52_F0.6410.96
78_E89_G0.6230.95
57_E65_R0.6200.95
7_A11_R0.6100.94
94_L98_L0.6100.94
29_R77_N0.6030.94
32_R36_I0.6000.94
32_R35_E0.5990.94
22_V101_I0.5980.94
18_A45_N0.5980.94
19_H53_L0.5960.94
99_R106_R0.5870.93
69_T73_H0.5700.92
80_L83_A0.5620.92
40_A90_A0.5540.91
56_S66_G0.5520.91
76_V101_I0.5520.91
33_A42_I0.5520.91
26_N30_A0.5470.90
78_E82_K0.5470.90
99_R103_E0.5440.90
40_A84_D0.5430.90
79_R83_A0.5380.90
100_K104_E0.5360.90
31_P77_N0.5350.89
30_A33_A0.5330.89
57_E60_G0.5270.89
74_E77_N0.5270.89
36_I80_L0.5260.89
56_S63_G0.5220.88
31_P81_D0.5220.88
78_E81_D0.5210.88
8_G12_P0.5190.88
100_K103_E0.5160.88
11_R38_K0.5140.88
83_A94_L0.5130.87
17_Q52_F0.5130.87
86_S94_L0.5120.87
97_E101_I0.5090.87
89_G97_E0.5080.87
7_A14_P0.5060.87
82_K100_K0.5030.86
85_K93_A0.5030.86
79_R101_I0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fr2B 1 0.4404 55.2 0.841 Contact Map
3zfkA 1 0.4312 55 0.841 Contact Map
7ceiB 1 0.4404 47.8 0.847 Contact Map
4qkoB 2 0.4587 38.5 0.856 Contact Map
4uhqA 1 0.5138 32.1 0.862 Contact Map
1xreA 2 0.6514 23.6 0.87 Contact Map
3vlcE 1 0.2294 13 0.885 Contact Map
2lsoA 1 0.4128 12.6 0.886 Contact Map
3s4wB 1 0.6606 12.5 0.886 Contact Map
4ogeA 1 0.789 11.4 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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