GREMLIN Database
RLAN - RimK-like ATPgrasp N-terminal domain
PFAM: PF14401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (146)
Sequences: 3142 (2129)
Seq/√Len: 176.2
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_R108_E4.0241.00
3_D7_D3.4981.00
117_V128_L3.4831.00
106_L117_V3.4021.00
13_L16_A3.0921.00
88_S116_R2.9091.00
88_S143_H2.5041.00
89_I103_A2.4391.00
86_T116_R2.3391.00
97_K100_D2.3171.00
120_V129_Q2.2951.00
51_T112_A2.2051.00
83_D121_R2.2021.00
89_I117_V2.1911.00
105_Q109_L2.1571.00
71_L75_S2.1291.00
140_P143_H2.0891.00
4_Y43_H2.0631.00
69_D73_Q1.9951.00
86_T118_T1.9671.00
93_R100_D1.8861.00
139_L143_H1.8611.00
55_L133_P1.8181.00
46_I111_P1.7941.00
139_L147_F1.7091.00
144_R148_A1.6751.00
88_S94_N1.6591.00
69_D125_R1.6381.00
7_D10_Y1.6361.00
9_E12_E1.6091.00
79_P98_R1.5941.00
84_E118_T1.5441.00
26_R29_S1.4831.00
95_L143_H1.4581.00
96_A99_Y1.4511.00
10_Y13_L1.4211.00
88_S95_L1.4161.00
114_L139_L1.4121.00
87_L99_Y1.4041.00
112_A133_P1.3931.00
82_S96_A1.2821.00
60_L110_F1.2581.00
9_E13_L1.2471.00
94_N103_A1.2401.00
116_R134_I1.2401.00
39_E50_K1.2271.00
6_T10_Y1.2011.00
10_Y16_A1.1691.00
105_Q108_E1.1561.00
85_F119_F1.1411.00
141_E144_R1.1351.00
94_N99_Y1.1311.00
72_I75_S1.1301.00
53_Q56_K1.1201.00
20_N35_S1.1081.00
6_T14_R1.0991.00
122_R125_R1.0951.00
114_L134_I1.0561.00
50_K54_D1.0531.00
36_L49_V1.0210.99
73_Q125_R1.0110.99
90_Y140_P1.0050.99
64_A110_F1.0050.99
61_Y65_S0.9930.99
73_Q76_L0.9880.99
80_I85_F0.9850.99
112_A115_L0.9810.99
2_R30_R0.9780.99
27_Y32_Y0.9770.99
21_L114_L0.9720.99
24_S56_K0.9570.99
8_P12_E0.9490.99
3_D9_E0.9430.99
87_L102_L0.9410.99
75_S99_Y0.9380.99
85_F126_W0.9380.99
119_F126_W0.9370.99
31_G38_A0.9340.99
80_I84_E0.9240.99
5_L30_R0.9240.99
37_L41_R0.9180.99
80_I99_Y0.9170.99
136_L144_R0.9130.99
85_F88_S0.9080.99
31_G35_S0.9040.99
38_A41_R0.9030.99
52_I56_K0.9020.99
94_N100_D0.8840.98
12_E15_R0.8820.98
21_L24_S0.8750.98
134_I138_D0.8680.98
25_Y29_S0.8660.98
89_I115_L0.8610.98
51_T133_P0.8570.98
82_S85_F0.8520.98
114_L147_F0.8510.98
121_R126_W0.8490.98
55_L115_L0.8460.98
7_D11_S0.8430.98
53_Q110_F0.8420.98
95_L146_F0.8420.98
141_E145_D0.8410.98
34_V126_W0.8390.98
65_S128_L0.8360.98
101_R104_R0.8350.98
35_S52_I0.8310.98
34_V43_H0.8310.98
3_D70_E0.8060.97
48_S111_P0.8060.97
17_R44_R0.7970.97
22_C34_V0.7930.97
3_D10_Y0.7920.97
55_L61_Y0.7860.97
71_L74_K0.7820.96
121_R124_G0.7780.96
144_R147_F0.7730.96
66_E70_E0.7660.96
36_L41_R0.7620.96
37_L40_A0.7580.96
20_N31_G0.7550.96
44_R51_T0.7530.96
75_S103_A0.7500.96
117_V131_I0.7490.95
49_V53_Q0.7480.95
2_R10_Y0.7450.95
81_K88_S0.7430.95
22_C40_A0.7320.95
145_D148_A0.7320.95
53_Q111_P0.7300.95
28_Q54_D0.7250.95
39_E61_Y0.7230.95
110_F131_I0.7170.94
80_I83_D0.7150.94
55_L112_A0.7150.94
94_N143_H0.7150.94
11_S16_A0.7050.94
57_S64_A0.6990.94
70_E74_K0.6970.93
19_I91_F0.6940.93
79_P142_E0.6920.93
56_K61_Y0.6900.93
46_I107_F0.6870.93
139_L144_R0.6810.93
31_G52_I0.6800.93
30_R50_K0.6780.92
118_T124_G0.6770.92
24_S29_S0.6740.92
45_V146_F0.6660.92
105_Q111_P0.6590.91
22_C126_W0.6560.91
62_R65_S0.6510.91
59_S128_L0.6460.91
6_T11_S0.6440.90
120_V127_R0.6400.90
38_A43_H0.6360.90
44_R108_E0.6330.90
76_L85_F0.6320.90
78_A129_Q0.6270.89
88_S114_L0.6180.89
64_A109_L0.6180.89
74_K85_F0.6100.88
59_S62_R0.6080.88
90_Y146_F0.6060.88
8_P23_R0.6050.87
100_D103_A0.6050.87
88_S134_I0.6030.87
76_L119_F0.6030.87
49_V107_F0.6000.87
76_L80_I0.5930.86
131_I136_L0.5910.86
36_L40_A0.5870.86
134_I140_P0.5840.86
95_L147_F0.5790.85
87_L119_F0.5780.85
56_K60_L0.5720.84
12_E39_E0.5610.83
128_L147_F0.5610.83
74_K101_R0.5580.83
58_K61_Y0.5580.83
96_A143_H0.5570.83
37_L43_H0.5530.82
106_L137_S0.5520.82
118_T132_R0.5520.82
57_S60_L0.5490.82
48_S110_F0.5480.82
68_L102_L0.5430.81
25_Y135_S0.5430.81
5_L17_R0.5390.81
71_L105_Q0.5390.81
24_S51_T0.5390.81
85_F96_A0.5390.81
95_L142_E0.5380.81
45_V93_R0.5350.80
39_E55_L0.5340.80
70_E73_Q0.5340.80
81_K121_R0.5330.80
6_T109_L0.5320.80
63_L118_T0.5320.80
81_K86_T0.5310.80
39_E54_D0.5310.80
95_L99_Y0.5300.80
28_Q112_A0.5300.80
61_Y128_L0.5290.80
108_E114_L0.5260.79
48_S97_K0.5250.79
6_T9_E0.5230.79
136_L141_E0.5230.79
10_Y14_R0.5220.79
118_T129_Q0.5160.78
7_D16_A0.5160.78
23_R39_E0.5150.78
3_D13_L0.5140.78
7_D12_E0.5120.77
49_V131_I0.5090.77
93_R104_R0.5090.77
87_L117_V0.5050.76
3_D6_T0.5020.76
48_S61_Y0.5010.76
6_T12_E0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cs6A 1 0.56 30.8 0.93 Contact Map
3orsA 5 0.3467 19.8 0.936 Contact Map
3lp6A 5 0.3867 18.4 0.937 Contact Map
3rg8A 6 0.3533 13.5 0.941 Contact Map
3ooxA 1 0.6333 11.4 0.943 Contact Map
3on7A 4 0.56 11 0.943 Contact Map
3oowA 5 0.3467 10.8 0.944 Contact Map
3trhA 5 0.3533 10 0.944 Contact Map
4grdA 5 0.3867 9.7 0.945 Contact Map
2vk9A 1 0.7867 9.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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