GREMLIN Database
DUF4419 - Domain of unknown function (DUF4419)
PFAM: PF14388 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 301 (290)
Sequences: 1150 (1019)
Seq/√Len: 59.8
META: 0.683

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_L171_D4.7961.00
172_E184_D4.7051.00
139_P177_A4.2581.00
55_E123_E3.5051.00
101_T104_E3.3421.00
143_E178_E3.2281.00
7_V17_L3.1911.00
54_K83_N3.0641.00
80_I113_M2.9871.00
39_N42_E2.9001.00
136_E294_R2.8401.00
68_D71_E2.7681.00
173_F176_A2.6841.00
153_A164_D2.6341.00
60_F63_G2.6011.00
53_K121_E2.5841.00
79_Q82_E2.5761.00
146_L174_V2.5601.00
32_F36_V2.4921.00
32_F155_Y2.4561.00
149_A170_L2.3861.00
150_E167_R2.2961.00
96_D144_K2.2851.00
144_K148_R2.2661.00
139_P178_E2.2551.00
18_V292_A2.2291.00
76_F113_M2.2171.00
117_K260_P2.1491.00
143_E147_D2.1091.00
8_H192_Y2.1051.00
3_F27_L2.1001.00
28_I152_L2.0591.00
153_A163_T2.0351.00
261_F274_M2.0331.00
44_R48_V2.0311.00
95_P108_S2.0181.00
261_F276_L2.0011.00
145_I148_R1.9561.00
284_E296_E1.9541.00
47_F119_Y1.9481.00
55_E121_E1.9391.00
56_L79_Q1.8861.00
165_E211_K1.8641.00
96_D108_S1.8411.00
286_D289_T1.7310.99
262_K273_P1.7180.99
81_A90_R1.6980.99
27_L212_F1.6840.99
229_N232_L1.6690.99
107_A297_I1.6620.99
72_V124_V1.6620.99
146_L167_R1.6480.99
31_G214_P1.6470.99
60_F64_L1.6250.99
127_G200_S1.6190.99
41_E44_R1.5950.99
126_T263_W1.5930.99
63_G67_N1.5850.99
94_V109_E1.5790.99
63_G66_D1.5680.99
126_T200_S1.5510.98
172_E175_A1.5300.98
20_S23_D1.5250.98
197_G202_P1.5230.98
264_D269_G1.5230.98
153_A160_E1.5120.98
3_F19_L1.4970.98
64_L67_N1.4790.98
6_A283_V1.4710.98
24_I173_F1.4590.98
60_F67_N1.4550.98
44_R50_H1.4520.98
59_E63_G1.4440.98
262_K271_E1.4340.97
280_F297_I1.4280.97
162_W214_P1.4240.97
191_I208_W1.4220.97
22_D99_T1.4140.97
73_F106_I1.4050.97
37_N118_S1.3980.97
39_N43_L1.3960.97
44_R52_G1.3840.97
57_V123_E1.3740.97
6_A17_L1.3660.97
149_A163_T1.3600.96
40_A43_L1.3510.96
160_E163_T1.3430.96
181_G184_D1.3330.96
263_W274_M1.3310.96
37_N117_K1.3170.96
61_D67_N1.3080.96
96_D105_R1.3070.96
42_E158_D1.2960.95
8_H12_A1.2870.95
29_L111_T1.2750.95
36_V155_Y1.2550.94
264_D271_E1.2340.94
48_V52_G1.2290.94
110_I278_A1.2100.93
139_P143_E1.1950.93
22_D26_L1.1910.93
116_M122_Y1.1900.93
258_S275_E1.1820.92
140_E143_E1.1820.92
169_I211_K1.1820.92
23_D136_E1.1790.92
142_W162_W1.1690.92
48_V119_Y1.1530.91
32_F93_L1.1470.91
35_H215_Y1.1440.91
76_F80_I1.1230.90
60_F75_E1.1220.90
23_D280_F1.1220.90
196_S203_P1.1130.90
26_L297_I1.1090.90
126_T202_P1.1010.89
216_D220_K1.0960.89
93_L112_L1.0960.89
60_F65_L1.0890.89
171_D175_A1.0860.89
145_I149_A1.0820.89
123_E264_D1.0780.88
36_V43_L1.0740.88
56_L83_N1.0660.88
3_F212_F1.0480.87
16_P132_S1.0430.87
255_G280_F1.0370.86
43_L46_R1.0300.86
50_H54_K1.0300.86
40_A44_R1.0260.86
27_L280_F1.0230.86
282_G298_G1.0230.86
31_G35_H1.0220.86
35_H43_L1.0160.85
61_D64_L1.0160.85
77_S112_L1.0070.85
20_S104_E1.0050.85
45_S51_E0.9990.84
285_Q291_L0.9980.84
9_L13_Q0.9950.84
151_K154_E0.9840.83
34_F38_A0.9830.83
40_A119_Y0.9780.83
100_T104_E0.9770.83
228_R232_L0.9580.82
22_D25_W0.9560.82
111_T257_S0.9460.81
176_A184_D0.9440.81
22_D100_T0.9430.81
80_I83_N0.9420.81
140_E144_K0.9350.80
169_I191_I0.9350.80
3_F280_F0.9340.80
31_G215_Y0.9330.80
59_E62_G0.9250.79
62_G67_N0.9210.79
175_A182_K0.9210.79
23_D27_L0.9110.78
7_V209_I0.9080.78
23_D294_R0.9080.78
48_V120_F0.9030.78
77_S80_I0.8950.77
2_G5_A0.8940.77
150_E163_T0.8910.77
77_S109_E0.8910.77
15_R293_L0.8860.76
58_V72_V0.8860.76
159_L162_W0.8830.76
178_E182_K0.8820.76
71_E75_E0.8760.76
60_F66_D0.8670.75
80_I84_I0.8670.75
35_H39_N0.8610.74
46_R154_E0.8600.74
72_V76_F0.8590.74
110_I276_L0.8560.74
2_G6_A0.8560.74
50_H119_Y0.8550.74
289_T292_A0.8490.73
12_A200_S0.8470.73
57_V125_Y0.8450.73
205_I252_L0.8450.73
265_D268_N0.8380.72
167_R171_D0.8360.72
28_I170_L0.8320.72
26_L280_F0.8290.71
41_E48_V0.8280.71
174_V178_E0.8230.71
135_L177_A0.8230.71
44_R120_F0.8110.70
142_W145_I0.8100.70
43_L48_V0.8090.70
56_L261_F0.8080.70
158_D161_W0.8060.69
110_I259_V0.8040.69
8_H193_K0.7980.69
213_F253_P0.7920.68
40_A118_S0.7880.68
197_G200_S0.7850.67
108_S111_T0.7850.67
41_E50_H0.7830.67
56_L80_I0.7820.67
1_H6_A0.7790.67
139_P174_V0.7790.67
26_L30_Q0.7710.66
149_A167_R0.7710.66
123_E251_D0.7630.65
171_D174_V0.7630.65
142_W170_L0.7610.65
69_W73_F0.7560.64
115_A118_S0.7540.64
35_H181_G0.7540.64
77_S90_R0.7480.64
200_S204_Y0.7410.63
114_D117_K0.7410.63
73_F80_I0.7370.62
89_L155_Y0.7370.62
113_M122_Y0.7370.62
76_F124_V0.7360.62
84_I93_L0.7360.62
57_V264_D0.7360.62
55_E262_K0.7350.62
95_P100_T0.7340.62
20_S31_G0.7340.62
196_S200_S0.7340.62
265_D269_G0.7340.62
259_V276_L0.7310.62
26_L107_A0.7310.62
49_D85_G0.7300.62
18_V136_E0.7300.62
85_G89_L0.7280.61
103_V106_I0.7220.61
90_R154_E0.7200.61
75_E79_Q0.7160.60
102_P105_R0.7160.60
25_W97_F0.7130.60
74_P109_E0.7120.60
105_R170_L0.7120.60
4_V213_F0.7100.59
58_V76_F0.7060.59
261_F269_G0.7060.59
169_I208_W0.7050.59
35_H213_F0.7030.59
69_W263_W0.7010.59
193_K200_S0.7010.59
124_V261_F0.7010.59
264_D268_N0.7010.59
32_F163_T0.7000.58
175_A183_P0.6990.58
203_P248_D0.6970.58
193_K202_P0.6960.58
11_Y14_H0.6950.58
126_T267_D0.6930.58
30_Q280_F0.6900.57
266_Y269_G0.6880.57
8_H11_Y0.6870.57
113_M259_V0.6870.57
214_P280_F0.6860.57
169_I187_F0.6840.57
36_V115_A0.6840.57
81_A91_D0.6830.57
159_L215_Y0.6820.56
47_F116_M0.6800.56
166_L169_I0.6790.56
155_Y163_T0.6770.56
226_L229_N0.6770.56
62_G65_L0.6750.56
161_W214_P0.6750.56
55_E264_D0.6720.55
40_A50_H0.6660.55
263_W268_N0.6660.55
61_D65_L0.6650.55
83_N120_F0.6650.55
143_E174_V0.6640.54
196_S202_P0.6630.54
126_T268_N0.6590.54
185_K189_Q0.6580.54
274_M301_V0.6570.54
190_S206_S0.6570.54
52_G119_Y0.6540.53
11_Y190_S0.6530.53
192_Y209_I0.6530.53
205_I249_T0.6520.53
48_V54_K0.6510.53
74_P106_I0.6500.53
146_L150_E0.6500.53
62_G66_D0.6490.53
112_L116_M0.6480.53
248_D251_D0.6480.53
73_F109_E0.6450.52
277_V300_A0.6440.52
14_H128_C0.6430.52
131_P135_L0.6410.52
175_A184_D0.6370.51
46_R158_D0.6360.51
58_V79_Q0.6350.51
225_K228_R0.6350.51
40_A48_V0.6280.50
22_D162_W0.6270.50
49_D171_D0.6270.50
277_V291_L0.6270.50
58_V75_E0.6270.50
265_D272_Y0.6260.50
126_T199_G0.6220.50
88_E91_D0.6210.50
146_L149_A0.6200.50
26_L108_S0.6190.49
104_E297_I0.6190.49
16_P292_A0.6150.49
28_I42_E0.6140.49
7_V293_L0.6130.49
107_A259_V0.6130.49
92_L151_K0.6120.49
82_E154_E0.6120.49
174_V177_A0.6110.49
121_E262_K0.6110.49
263_W267_D0.6100.48
238_V241_G0.6100.48
158_D215_Y0.6090.48
12_A193_K0.6080.48
81_A86_D0.6050.48
105_R108_S0.6050.48
173_F177_A0.6050.48
31_G162_W0.6020.47
168_P188_W0.6010.47
3_F7_V0.6000.47
131_P134_T0.6000.47
228_R231_L0.5980.47
187_F282_G0.5980.47
208_W212_F0.5980.47
26_L111_T0.5950.47
165_E169_I0.5940.47
153_A167_R0.5930.46
139_P176_A0.5930.46
50_H53_K0.5880.46
133_I187_F0.5870.46
16_P130_I0.5870.46
173_F188_W0.5860.46
29_L108_S0.5860.46
193_K201_G0.5850.46
143_E146_L0.5840.45
145_I170_L0.5840.45
33_A190_S0.5830.45
28_I166_L0.5800.45
140_E185_K0.5790.45
132_S135_L0.5780.45
111_T117_K0.5770.45
90_R112_L0.5760.45
2_G11_Y0.5750.44
43_L155_Y0.5740.44
29_L33_A0.5720.44
116_M126_T0.5700.44
30_Q111_T0.5700.44
56_L189_Q0.5680.44
54_K58_V0.5670.44
44_R51_E0.5670.44
90_R255_G0.5650.43
165_E212_F0.5650.43
155_Y280_F0.5640.43
283_V293_L0.5640.43
131_P299_W0.5630.43
33_A37_N0.5620.43
2_G17_L0.5610.43
7_V191_I0.5600.43
21_P25_W0.5600.43
73_F102_P0.5590.43
16_P285_Q0.5590.43
138_T176_A0.5580.43
190_S193_K0.5580.43
4_V205_I0.5580.43
105_R109_E0.5580.43
107_A278_A0.5540.42
187_F213_F0.5540.42
67_N110_I0.5540.42
30_Q285_Q0.5510.42
142_W188_W0.5490.42
177_A183_P0.5460.41
162_W181_G0.5460.41
159_L187_F0.5420.41
134_T166_L0.5410.41
199_G269_G0.5400.41
28_I145_I0.5380.40
99_T141_D0.5380.40
284_E294_R0.5370.40
126_T193_K0.5370.40
176_A188_W0.5370.40
133_I191_I0.5360.40
3_F32_F0.5360.40
16_P30_Q0.5350.40
286_D294_R0.5350.40
98_S144_K0.5340.40
114_D257_S0.5320.40
126_T203_P0.5310.40
1_H34_F0.5300.40
142_W173_F0.5260.39
93_L115_A0.5250.39
199_G249_T0.5240.39
51_E186_E0.5240.39
35_H285_Q0.5240.39
79_Q124_V0.5240.39
204_Y248_D0.5220.39
130_I187_F0.5220.39
191_I195_H0.5220.39
75_E78_D0.5210.39
73_F276_L0.5210.39
73_F76_F0.5210.39
152_L163_T0.5210.39
56_L76_F0.5200.39
113_M273_P0.5180.38
58_V217_K0.5160.38
88_E150_E0.5160.38
177_A181_G0.5160.38
55_E273_P0.5150.38
7_V29_L0.5130.38
22_D176_A0.5130.38
16_P23_D0.5120.38
12_A127_G0.5110.38
78_D112_L0.5110.38
41_E51_E0.5100.37
130_I191_I0.5100.37
83_N259_V0.5090.37
186_E190_S0.5080.37
15_R113_M0.5080.37
50_H83_N0.5080.37
40_A154_E0.5080.37
7_V19_L0.5080.37
94_V100_T0.5080.37
135_L176_A0.5060.37
176_A187_F0.5060.37
264_D267_D0.5050.37
17_L209_I0.5050.37
184_D282_G0.5050.37
163_T167_R0.5040.37
193_K263_W0.5030.37
210_T247_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jrtA 2 0.3355 39.3 0.963 Contact Map
4amgA 2 0.2625 17.7 0.969 Contact Map
4hlnA 1 0.2957 12.6 0.971 Contact Map
4p7aA 2 0.1993 9.5 0.972 Contact Map
3froA 3 0.3056 8.8 0.973 Contact Map
2iyfA 1 0.2724 8.2 0.973 Contact Map
2q83A 1 0.2027 8.1 0.973 Contact Map
4fkzA 2 0.3223 6.6 0.974 Contact Map
4pqgA 2 0.2857 6.3 0.974 Contact Map
3tixB 1 0.2625 5.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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