GREMLIN Database
DUF4418 - Domain of unknown function (DUF4418)
PFAM: PF14387 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (114)
Sequences: 1132 (938)
Seq/√Len: 87.8
META: 0.863

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_T78_I3.0791.00
18_V35_A2.6671.00
85_V98_F2.6421.00
9_A42_G2.4411.00
40_G82_L2.2571.00
63_G67_G2.1911.00
16_F100_A2.1511.00
80_T102_I2.0101.00
10_L14_F2.0101.00
38_E75_A2.0011.00
41_I78_I1.9171.00
32_H36_R1.9161.00
11_G14_F1.8491.00
40_G74_L1.8251.00
85_V94_R1.8031.00
48_L67_G1.8031.00
37_A83_I1.8021.00
65_S115_N1.7871.00
76_I105_G1.7781.00
38_E101_L1.7621.00
8_I101_L1.7151.00
12_P42_G1.7061.00
75_A105_G1.6881.00
33_W83_I1.6481.00
94_R98_F1.6331.00
9_A46_A1.6311.00
72_G105_G1.5581.00
88_M91_M1.5231.00
45_I68_I1.4921.00
77_L81_V1.4820.99
5_G42_G1.4530.99
34_T84_G1.4510.99
6_L10_L1.4470.99
102_I106_I1.4340.99
72_G108_L1.4280.99
37_A78_I1.3560.99
16_F19_C1.3550.99
18_V97_T1.3540.99
76_I109_I1.3400.99
110_V114_I1.3290.99
11_G16_F1.3010.99
33_W36_R1.2910.99
72_G109_I1.2880.99
92_A96_V1.2690.98
76_I102_I1.2530.98
30_K33_W1.1590.97
52_L64_L1.1580.97
60_T63_G1.1500.97
52_L61_R1.1260.97
68_I112_S1.1100.96
98_F102_I1.1050.96
80_T85_V1.1020.96
21_S28_M1.1010.96
100_A104_L1.0820.96
2_I49_G1.0800.96
10_L15_L1.0770.96
34_T79_P1.0540.95
8_I75_A1.0460.95
47_A51_L1.0420.95
74_L78_I1.0410.95
40_G63_G1.0390.95
2_I53_L1.0140.94
89_P94_R1.0080.94
21_S24_D1.0060.94
24_D91_M1.0030.94
4_L107_L0.9860.93
103_V107_L0.9580.92
48_L64_L0.9520.92
29_M86_C0.9380.91
39_I43_I0.9360.91
70_L73_I0.9330.91
6_L66_I0.9050.90
85_V102_I0.9040.90
78_I83_I0.8820.88
13_Q39_I0.8750.88
13_Q35_A0.8750.88
35_A38_E0.8660.87
18_V21_S0.8480.86
4_L7_L0.8350.85
40_G83_I0.8290.85
33_W40_G0.8210.84
80_T84_G0.8120.84
18_V32_H0.8000.83
4_L108_L0.7970.83
50_I54_F0.7940.82
41_I71_L0.7790.81
30_K88_M0.7750.81
33_W63_G0.7630.80
20_E23_G0.7570.79
43_I74_L0.7530.79
3_V71_L0.7470.78
5_G49_G0.7450.78
18_V22_M0.7410.78
73_I107_L0.7370.77
34_T97_T0.7210.76
2_I46_A0.7200.76
16_F38_E0.7140.75
44_L71_L0.7130.75
50_I89_P0.7040.74
50_I113_L0.7040.74
8_I68_I0.7030.74
22_M27_K0.6980.74
12_P15_L0.6960.73
28_M36_R0.6920.73
18_V44_L0.6890.73
44_L51_L0.6890.73
14_F17_P0.6820.72
97_T101_L0.6820.72
11_G15_L0.6790.72
31_C86_C0.6790.72
34_T37_A0.6750.71
8_I12_P0.6670.70
87_A92_A0.6670.70
7_L18_V0.6660.70
55_F59_K0.6560.69
5_G12_P0.6550.69
49_G68_I0.6550.69
96_V99_P0.6530.69
9_A12_P0.6480.68
36_R41_I0.6460.68
60_T66_I0.6440.68
28_M33_W0.6430.67
41_I75_A0.6420.67
80_T98_F0.6420.67
32_H91_M0.6380.67
49_G85_V0.6380.67
34_T85_V0.6350.66
50_I56_K0.6340.66
73_I109_I0.6340.66
51_L59_K0.6330.66
104_L111_L0.6280.66
77_L82_L0.6240.65
35_A39_I0.6230.65
10_L13_Q0.6190.64
13_Q17_P0.6160.64
11_G96_V0.6160.64
11_G100_A0.6150.64
16_F99_P0.6020.62
7_L104_L0.6000.62
74_L82_L0.5900.61
30_K83_I0.5870.60
23_G87_A0.5800.59
12_P97_T0.5750.59
88_M114_I0.5740.59
5_G9_A0.5740.59
4_L104_L0.5700.58
8_I108_L0.5670.58
56_K109_I0.5640.57
47_A70_L0.5600.57
104_L115_N0.5580.57
11_G17_P0.5500.55
46_A50_I0.5490.55
5_G11_G0.5480.55
45_I108_L0.5410.54
36_R78_I0.5390.54
59_K62_L0.5370.54
29_M95_T0.5360.54
51_L55_F0.5340.53
24_D28_M0.5330.53
28_M53_L0.5320.53
101_L105_G0.5310.53
24_D27_K0.5280.53
35_A85_V0.5280.53
61_R81_V0.5250.52
44_L57_D0.5210.52
31_C93_C0.5180.51
53_L114_I0.5100.50
43_I113_L0.5040.49
52_L56_K0.5020.49
96_V100_A0.5000.49
33_W67_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.4915 4.9 0.926 Contact Map
4o6yA 2 0.8814 4.7 0.927 Contact Map
4ev6A 3 0.4915 4.1 0.929 Contact Map
2jwaA 2 0.339 2.4 0.937 Contact Map
3b5dA 2 0.6271 1.5 0.944 Contact Map
2ks1B 1 0.2712 0.9 0.95 Contact Map
3ux4A 3 0.6017 0.8 0.952 Contact Map
3x29A 1 0.7627 0.7 0.954 Contact Map
2a65A 2 0.7542 0.7 0.955 Contact Map
2xq2A 2 0.6949 0.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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