GREMLIN Database
DUF4417 - Domain of unknown function (DUF4417)
PFAM: PF14386 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (175)
Sequences: 1904 (1594)
Seq/√Len: 120.5
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_E157_E3.8081.00
71_T96_G3.5811.00
154_E158_R3.4121.00
39_G68_G3.1341.00
127_K160_E2.8731.00
43_F132_A2.5401.00
128_G160_E2.4691.00
43_F109_N2.4571.00
113_G117_S2.3191.00
83_A86_I2.1281.00
53_W91_R2.1231.00
27_S44_L2.0921.00
6_Y86_I2.0351.00
115_E150_A2.0101.00
97_A101_S1.9891.00
3_D10_I1.9731.00
84_M87_W1.9461.00
110_V125_I1.9371.00
69_V99_W1.9291.00
89_I93_R1.8341.00
110_V155_M1.8201.00
70_I109_N1.7181.00
88_N91_R1.7161.00
29_A62_K1.6381.00
131_V164_I1.6051.00
93_R125_I1.6041.00
55_N58_K1.5891.00
130_V163_T1.5711.00
27_S48_R1.5691.00
156_L164_I1.5611.00
26_F59_Y1.5571.00
131_V155_M1.5481.00
133_I152_L1.5471.00
112_W151_G1.5441.00
22_K38_K1.5351.00
60_L102_N1.5291.00
95_I99_W1.4911.00
69_V104_I1.4731.00
122_F155_M1.4711.00
82_L116_R1.4641.00
89_I92_N1.4491.00
25_P41_H1.4361.00
146_E150_A1.4351.00
51_R59_Y1.4271.00
4_G123_D1.4181.00
82_L120_F1.4181.00
14_T105_K1.4151.00
155_M159_L1.4151.00
57_E98_Y1.3981.00
53_W74_F1.3961.00
5_K119_D1.3821.00
83_A90_Y1.3731.00
4_G7_E1.3701.00
85_Q117_S1.3651.00
85_Q120_F1.3561.00
25_P44_L1.3051.00
89_I120_F1.2951.00
42_F49_F1.2931.00
80_M84_M1.2851.00
25_P28_K1.2781.00
63_L69_V1.2430.99
93_R124_G1.2340.99
13_P100_Q1.2150.99
50_E91_R1.2140.99
125_I131_V1.2060.99
40_V63_L1.1910.99
23_L41_H1.1890.99
12_K100_Q1.1790.99
70_I132_A1.1570.99
117_S120_F1.1510.99
11_I126_P1.1510.99
87_W91_R1.1460.99
11_I71_T1.1430.99
61_E64_K1.1390.99
122_F154_E1.1290.99
60_L98_Y1.1250.99
4_G10_I1.1210.99
130_V162_S1.1200.99
45_D48_R1.0990.99
78_R147_L1.0980.99
152_L164_I1.0780.98
123_D158_R1.0630.98
14_T17_I1.0590.98
64_K102_N1.0570.98
82_L86_I1.0500.98
78_R144_D1.0440.98
50_E54_N1.0430.98
37_N67_K1.0420.98
118_Y122_F1.0370.98
112_W122_F1.0220.98
36_K65_K1.0210.98
62_K65_K1.0040.97
52_V99_W0.9970.97
21_D37_N0.9830.97
152_L178_I0.9740.97
94_W97_A0.9570.97
49_F52_V0.9530.97
99_W104_I0.9520.97
110_V131_V0.9510.96
7_E82_L0.9440.96
53_W87_W0.9370.96
118_Y151_G0.9340.96
148_F151_G0.9320.96
76_L113_G0.9280.96
23_L70_I0.9260.96
6_Y83_A0.9240.96
12_K126_P0.9160.96
76_L111_R0.9120.96
52_V95_I0.9120.96
63_L99_W0.9080.95
35_D65_K0.9070.95
141_S144_D0.9030.95
111_R134_S0.9020.95
171_P174_M0.8960.95
22_K35_D0.8930.95
29_A40_V0.8910.95
42_F52_V0.8830.95
152_L155_M0.8800.95
26_F63_L0.8790.95
92_N125_I0.8780.95
108_P125_I0.8780.95
64_K104_I0.8700.94
42_F63_L0.8690.94
50_E53_W0.8680.94
118_Y150_A0.8640.94
149_L173_E0.8590.94
112_W121_C0.8500.94
172_D175_F0.8440.93
17_I20_P0.8410.93
73_D109_N0.8400.93
71_T92_N0.8400.93
5_K82_L0.8380.93
166_V170_P0.8370.93
85_Q113_G0.8290.93
12_K97_A0.8270.93
56_P95_I0.8260.93
128_G162_S0.8220.92
26_F42_F0.8180.92
22_K37_N0.8140.92
107_I132_A0.8100.92
43_F70_I0.8050.92
128_G159_L0.8030.91
56_P99_W0.8010.91
11_I96_G0.7930.91
90_Y94_W0.7830.90
52_V63_L0.7790.90
76_L89_I0.7770.90
122_F151_G0.7740.90
84_M88_N0.7700.90
135_T166_V0.7580.89
150_A153_E0.7470.88
127_K159_L0.7460.88
98_Y102_N0.7430.88
8_I123_D0.7350.87
81_P90_Y0.7330.87
12_K16_I0.7280.87
73_D111_R0.7250.87
74_F95_I0.7250.87
166_V175_F0.7240.87
115_E118_Y0.7190.86
131_V159_L0.7180.86
85_Q114_D0.7090.85
153_E177_N0.7070.85
172_D176_G0.7040.85
57_E102_N0.6970.84
28_K48_R0.6950.84
16_I105_K0.6930.84
72_P96_G0.6920.84
63_L66_F0.6910.84
24_I29_A0.6880.84
118_Y121_C0.6880.84
15_D162_S0.6880.84
81_P84_M0.6870.84
83_A87_W0.6860.84
60_L99_W0.6840.83
13_P16_I0.6820.83
13_P126_P0.6790.83
149_L177_N0.6740.82
59_Y95_I0.6720.82
89_I110_V0.6650.82
110_V159_L0.6640.82
142_K145_R0.6620.81
139_I171_P0.6600.81
134_S167_Y0.6530.80
58_K62_K0.6520.80
7_E116_R0.6470.80
23_L39_G0.6450.80
56_P94_W0.6440.80
152_L175_F0.6420.79
145_R149_L0.6380.79
117_S121_C0.6380.79
26_F51_R0.6300.78
174_M177_N0.6290.78
83_A91_R0.6260.78
114_D117_S0.6240.77
74_F91_R0.6240.77
24_I40_V0.6230.77
94_W98_Y0.6200.77
87_W90_Y0.6200.77
56_P59_Y0.6180.77
153_E157_E0.6180.77
11_I108_P0.6120.76
50_E87_W0.6100.76
161_P168_G0.6060.75
3_D123_D0.6050.75
53_W88_N0.6020.75
119_D158_R0.6020.75
90_Y124_G0.5940.74
111_R138_C0.5920.74
148_F155_M0.5840.73
153_E178_I0.5830.72
63_L104_I0.5820.72
157_E160_E0.5760.72
6_Y82_L0.5750.71
62_K66_F0.5750.71
32_K35_D0.5750.71
125_I129_S0.5740.71
60_L104_I0.5740.71
82_L118_Y0.5730.71
71_T106_V0.5720.71
170_P174_M0.5690.71
152_L156_L0.5680.71
133_I148_F0.5670.70
122_F131_V0.5580.69
129_S159_L0.5560.69
97_A100_Q0.5550.69
26_F44_L0.5530.69
143_E146_E0.5510.68
41_H70_I0.5500.68
49_F98_Y0.5480.68
33_K36_K0.5450.67
117_S147_L0.5430.67
82_L85_Q0.5430.67
155_M164_I0.5420.67
93_R120_F0.5400.67
53_W90_Y0.5380.66
21_D67_K0.5380.66
39_G70_I0.5350.66
29_A66_F0.5350.66
134_S137_G0.5350.66
59_Y63_L0.5320.66
51_R54_N0.5320.66
23_L26_F0.5300.65
152_L166_V0.5290.65
44_L49_F0.5270.65
93_R135_T0.5250.65
120_F123_D0.5240.64
126_P129_S0.5230.64
30_K62_K0.5230.64
92_N109_N0.5210.64
48_R51_R0.5190.64
133_I151_G0.5190.64
71_T109_N0.5190.64
111_R136_V0.5180.64
56_P60_L0.5150.63
11_I14_T0.5150.63
71_T110_V0.5150.63
73_D137_G0.5090.62
119_D123_D0.5070.62
138_C148_F0.5060.62
7_E81_P0.5040.61
21_D58_K0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q6tA 1 0.7713 16.9 0.944 Contact Map
4jc0A 1 0.5 15 0.945 Contact Map
2bfwA 1 0.4255 10.3 0.949 Contact Map
3pdiB 2 0.5851 9.3 0.95 Contact Map
3aekB 2 0.5585 9.3 0.95 Contact Map
2ynmD 2 0.5585 6.9 0.953 Contact Map
3qv2A 1 0.7128 6.8 0.953 Contact Map
2o6lA 2 0.3936 5.7 0.955 Contact Map
3u7qA 1 0.7819 5.3 0.955 Contact Map
2hiqA 2 0.4362 5.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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