GREMLIN Database
DUF4416 - Domain of unknown function (DUF4416)
PFAM: PF14385 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (160)
Sequences: 4820 (3824)
Seq/√Len: 302.3
META: 0.962

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R76_A3.1881.00
21_L34_E3.0481.00
23_R83_E2.6521.00
5_F104_L2.6081.00
134_S155_N2.5801.00
44_D47_E2.5101.00
3_K32_D2.4371.00
109_T122_I2.2561.00
47_E52_P2.1991.00
70_L107_A2.0141.00
151_I155_N2.0051.00
153_F157_V1.9201.00
6_V94_L1.9071.00
72_D120_D1.9001.00
30_P62_E1.8891.00
42_F147_S1.8851.00
4_L65_I1.8021.00
129_I138_L1.8011.00
134_S151_I1.7881.00
60_S157_V1.7581.00
82_E85_A1.7571.00
69_E72_D1.6921.00
32_D60_S1.6871.00
103_K111_D1.6381.00
58_F150_Y1.5761.00
100_T103_K1.5681.00
65_I73_I1.5461.00
33_L153_F1.5401.00
39_P55_K1.5301.00
12_D15_E1.5221.00
34_E57_R1.5101.00
8_V94_L1.4961.00
2_V67_P1.4941.00
148_P152_E1.4921.00
4_L28_F1.4871.00
9_L56_R1.4751.00
76_A79_E1.4731.00
9_L54_L1.4471.00
4_L73_I1.4401.00
102_A111_D1.4151.00
72_D119_G1.4041.00
65_I98_Y1.3691.00
137_P151_I1.3641.00
105_V116_I1.3371.00
67_P103_K1.3301.00
24_L61_F1.3241.00
76_A80_L1.3241.00
2_V100_T1.3171.00
40_F140_W1.2911.00
148_P151_I1.2891.00
50_M54_L1.2881.00
131_R136_Q1.2741.00
118_L124_A1.2651.00
37_P57_R1.2421.00
8_V59_L1.2391.00
104_L154_F1.2251.00
6_V24_L1.2071.00
28_F73_I1.1931.00
78_N122_I1.1881.00
100_T111_D1.1811.00
6_V61_F1.1781.00
7_G56_R1.1721.00
23_R84_F1.1531.00
113_S129_I1.1441.00
71_A119_G1.1421.00
116_I124_A1.1381.00
156_R159_E1.1221.00
131_R139_P1.1201.00
47_E54_L1.1171.00
25_E30_P1.1151.00
20_A84_F1.1021.00
10_S37_P1.0881.00
102_A112_Y1.0871.00
75_L120_D1.0721.00
137_P146_R1.0581.00
130_Y135_F1.0511.00
147_S150_Y1.0401.00
126_V138_L1.0361.00
152_E156_R1.0351.00
2_V98_Y1.0311.00
99_L104_L1.0261.00
23_R26_E1.0231.00
86_R91_R1.0171.00
65_I69_E1.0141.00
115_R125_E1.0071.00
25_E31_I0.9961.00
112_Y142_Y0.9911.00
56_R144_D0.9871.00
111_D123_Y0.9841.00
86_R89_K0.9841.00
69_E73_I0.9831.00
23_R27_R0.9761.00
38_F56_R0.9731.00
68_E119_G0.9711.00
28_F76_A0.9691.00
21_L25_E0.9681.00
106_L127_T0.9651.00
3_K60_S0.9581.00
67_P100_T0.9571.00
22_E25_E0.9541.00
33_L157_V0.9531.00
7_G58_F0.9491.00
135_F155_N0.9491.00
5_F60_S0.9471.00
71_A120_D0.9471.00
21_L59_L0.9461.00
47_E53_P0.9421.00
22_E26_E0.9331.00
103_K116_I0.9311.00
5_F157_V0.9271.00
111_D116_I0.9261.00
79_E82_E0.9221.00
67_P102_A0.9161.00
150_Y154_F0.9131.00
40_F43_T0.9021.00
129_I139_P0.8911.00
78_N109_T0.8861.00
64_L161_Y0.8861.00
60_S153_F0.8801.00
33_L156_R0.8691.00
10_S16_L0.8631.00
18_E22_E0.8551.00
14_E18_E0.8541.00
12_D91_R0.8531.00
102_A113_S0.8511.00
19_E22_E0.8491.00
14_E37_P0.8471.00
115_R142_Y0.8441.00
10_S17_L0.8341.00
20_A92_V0.8191.00
108_T142_Y0.8181.00
58_F154_F0.8161.00
75_L78_N0.8151.00
8_V17_L0.8081.00
49_E91_R0.8071.00
79_E83_E0.8041.00
136_Q139_P0.8001.00
32_D160_K0.7961.00
15_E18_E0.7931.00
103_K129_I0.7921.00
9_L50_M0.7850.99
75_L122_I0.7830.99
16_L91_R0.7810.99
73_I96_P0.7790.99
135_F151_I0.7770.99
14_E55_K0.7770.99
19_E23_R0.7710.99
68_E117_Y0.7650.99
3_K157_V0.7630.99
132_K136_Q0.7580.99
31_I34_E0.7560.99
118_L122_I0.7490.99
113_S138_L0.7480.99
98_Y105_V0.7440.99
35_S38_F0.7360.99
72_D76_A0.7350.99
11_S54_L0.7220.99
34_E59_L0.7200.99
98_Y103_K0.7180.99
38_F153_F0.7180.99
112_Y115_R0.7160.99
33_L60_S0.7110.99
73_I77_T0.7110.99
115_R145_Y0.7090.99
16_L19_E0.6990.99
84_F91_R0.6980.99
6_V77_T0.6960.99
124_A127_T0.6950.99
115_R127_T0.6870.99
31_I61_F0.6850.99
10_S20_A0.6820.99
108_T112_Y0.6790.98
71_A75_L0.6730.98
8_V92_V0.6700.98
38_F58_F0.6680.98
17_L57_R0.6670.98
85_A89_K0.6620.98
21_L57_R0.6590.98
37_P55_K0.6580.98
71_A107_A0.6580.98
6_V59_L0.6550.98
68_E71_A0.6540.98
67_P123_Y0.6530.98
106_L125_E0.6520.98
129_I136_Q0.6440.98
84_F92_V0.6420.98
108_T114_H0.6340.98
85_A91_R0.6310.98
108_T113_S0.6290.98
11_S91_R0.6280.98
42_F145_Y0.6260.97
109_T125_E0.6230.97
67_P117_Y0.6230.97
113_S131_R0.6140.97
125_E142_Y0.6080.97
143_P146_R0.6060.97
24_L80_L0.6000.97
80_L84_F0.5940.97
36_P149_E0.5930.96
78_N82_E0.5850.96
109_T115_R0.5840.96
108_T125_E0.5820.96
33_L160_K0.5810.96
105_V124_A0.5670.95
12_D16_L0.5660.95
78_N107_A0.5610.95
16_L20_A0.5560.95
48_K89_K0.5560.95
75_L79_E0.5560.95
10_S14_E0.5540.95
46_Y110_K0.5540.95
117_Y125_E0.5530.95
45_Y110_K0.5500.95
39_P53_P0.5480.95
139_P146_R0.5470.95
2_V117_Y0.5470.95
140_W144_D0.5470.95
126_V140_W0.5450.94
114_H126_V0.5410.94
100_T112_Y0.5400.94
8_V57_R0.5390.94
35_S57_R0.5380.94
62_E160_K0.5330.94
78_N121_G0.5300.94
106_L145_Y0.5250.93
118_L121_G0.5250.93
44_D52_P0.5230.93
15_E19_E0.5210.93
90_R93_N0.5210.93
152_E155_N0.5200.93
71_A118_L0.5190.93
138_L141_T0.5190.93
41_D149_E0.5180.93
63_R69_E0.5180.93
10_S57_R0.5090.92
3_K160_K0.5080.92
1_P66_D0.5080.92
101_L113_S0.5070.92
104_L135_F0.5010.92
109_T127_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q0oA 2 0.6522 8.8 0.957 Contact Map
3d45A 2 0.5528 8.3 0.957 Contact Map
3biyA 1 0.8385 7.7 0.958 Contact Map
3wvzA 2 0.528 6.2 0.96 Contact Map
1vcoA 4 0.6211 5.4 0.961 Contact Map
2id1A 1 0.5714 5.4 0.961 Contact Map
4zdjA 4 0.6273 5.3 0.961 Contact Map
2o5aA 2 0.559 5.2 0.961 Contact Map
4bhwA 2 0.8385 4.9 0.961 Contact Map
4wcwA 2 0.5901 4.8 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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