GREMLIN Database
WAK_assoc - Wall-associated receptor kinase C-terminal
PFAM: PF14380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (96)
Sequences: 542 (446)
Seq/√Len: 45.6
META: 0.081

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_G100_Y3.7161.00
84_S101_C2.4451.00
13_Y17_S2.2041.00
11_S16_P2.0871.00
59_L100_Y2.0761.00
38_V97_F1.8830.99
15_F18_G1.8730.99
62_A67_F1.8660.99
39_V91_N1.7580.98
33_S98_V1.6920.98
63_L70_E1.6870.98
48_N52_S1.6710.98
81_C88_C1.6530.97
25_A28_N1.6220.97
62_A66_G1.5760.97
86_G99_C1.5660.96
34_C78_C1.5320.96
34_C81_C1.5120.96
44_G62_A1.4930.95
9_G16_P1.4730.95
75_A97_F1.4400.94
101_C104_G1.4320.94
34_C88_C1.4290.94
71_W90_Y1.4280.94
71_W76_G1.4260.94
68_E72_N1.3970.93
21_P24_E1.3950.93
60_G69_L1.3800.93
69_L102_S1.3630.92
59_L68_E1.3260.91
15_F55_T1.2770.90
41_P67_F1.2590.89
60_G82_E1.2470.89
29_D83_S1.2260.88
22_G29_D1.2250.88
66_G84_S1.2020.87
20_L56_S1.1960.87
14_V21_P1.1860.86
59_L63_L1.1680.85
68_E75_A1.1670.85
28_N93_T1.1560.85
67_F84_S1.1440.84
46_A62_A1.1370.84
61_E79_S1.1310.83
90_Y95_E1.1270.83
54_L57_D1.1250.83
89_G97_F1.1140.82
9_G12_S1.1110.82
24_E28_N1.1100.82
52_S91_N1.1100.82
17_S20_L1.1080.82
35_K87_R1.0950.81
59_L64_K1.0820.80
72_N92_Q1.0730.80
66_G101_C1.0540.79
27_L72_N1.0440.78
88_C99_C1.0290.77
34_C99_C1.0140.76
68_E77_D0.9880.74
46_A102_S0.9860.74
11_S17_S0.9490.71
44_G61_E0.9380.70
91_N95_E0.9280.69
78_C81_C0.9270.69
42_V82_E0.9130.68
61_E83_S0.9000.67
32_G79_S0.8770.65
56_S68_E0.8740.65
83_S104_G0.8710.64
79_S98_V0.8670.64
14_V20_L0.8640.64
36_E74_D0.8570.63
49_T61_E0.8540.63
65_Q75_A0.8420.62
46_A104_G0.8410.62
78_C88_C0.8400.61
39_V68_E0.8340.61
45_S50_L0.8100.59
44_G47_L0.8020.58
42_V54_L0.8000.58
33_S37_V0.7960.57
46_A75_A0.7840.56
20_L93_T0.7820.56
77_D98_V0.7780.56
16_P94_S0.7750.55
81_C99_C0.7750.55
19_D24_E0.7660.54
73_A77_D0.7630.54
65_Q70_E0.7580.54
21_P32_G0.7560.53
31_L102_S0.7530.53
16_P62_A0.7510.53
44_G104_G0.7500.53
91_N94_S0.7330.51
69_L74_D0.7290.51
33_S77_D0.7280.51
40_V67_F0.7050.48
58_G61_E0.7030.48
33_S43_L0.7010.48
35_K48_N0.7010.48
89_G101_C0.6950.47
63_L87_R0.6940.47
43_L100_Y0.6860.47
64_K85_G0.6820.46
90_Y101_C0.6650.45
90_Y100_Y0.6580.44
20_L23_S0.6550.44
37_V69_L0.6510.43
11_S14_V0.6500.43
16_P19_D0.6500.43
56_S76_G0.6370.42
51_E54_L0.6290.41
87_R100_Y0.6260.41
47_L70_E0.6250.41
15_F19_D0.6220.40
55_T83_S0.6210.40
71_W92_Q0.6190.40
39_V71_W0.6120.39
42_V100_Y0.6100.39
14_V28_N0.6100.39
72_N84_S0.6090.39
91_N101_C0.6070.39
15_F22_G0.6050.39
17_S49_T0.6030.39
45_S71_W0.5980.38
87_R92_Q0.5820.37
37_V80_Q0.5800.37
96_F100_Y0.5770.36
30_L60_G0.5710.36
75_A79_S0.5670.35
20_L31_L0.5630.35
31_L64_K0.5600.35
67_F81_C0.5580.35
37_V56_S0.5570.34
34_C86_G0.5560.34
35_K46_A0.5560.34
81_C86_G0.5540.34
62_A87_R0.5520.34
62_A70_E0.5320.32
72_N77_D0.5230.32
55_T72_N0.5120.31
10_G16_P0.5090.30
35_K96_F0.5010.30
38_V62_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a3pA 1 0.2596 23.7 0.88 Contact Map
2rnlA 1 0.3462 16.8 0.888 Contact Map
1ioxA 1 0.3077 15.4 0.89 Contact Map
1haeA 1 0.3077 15.3 0.89 Contact Map
1egfA 1 0.2981 12.3 0.894 Contact Map
3ltfD 1 0.3077 10.4 0.898 Contact Map
1k36A 1 0.2885 8.6 0.902 Contact Map
1d0qA 2 0.5865 8.2 0.903 Contact Map
1nziA 2 0.8269 8 0.903 Contact Map
3u7uG 1 0.2981 7 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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