GREMLIN Database
Cys_rich_CWC - Cysteine-rich CWC
PFAM: PF14375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (46)
Sequences: 5983 (3986)
Seq/√Len: 587.6
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_W47_P3.2601.00
6_A48_A2.7541.00
20_P25_E2.2411.00
29_S32_L1.8951.00
3_R45_L1.7731.00
26_V47_P1.7561.00
2_P8_F1.6071.00
28_L50_L1.5891.00
34_A37_P1.5751.00
30_P34_A1.5011.00
8_F43_D1.4691.00
35_R40_R1.4081.00
25_E47_P1.4051.00
14_A20_P1.3181.00
12_A15_G1.2611.00
2_P43_D1.2541.00
12_A24_A1.2511.00
20_P24_A1.2241.00
34_A38_E1.1391.00
36_L40_R1.1251.00
28_L33_L1.1231.00
28_L32_L1.1061.00
8_F47_P1.0301.00
32_L35_R1.0021.00
12_A16_G0.9551.00
11_G15_G0.9381.00
30_P33_L0.9251.00
13_A16_G0.9171.00
3_R41_Y0.9051.00
1_C4_C0.8881.00
32_L50_L0.8831.00
35_R38_E0.8631.00
35_R42_K0.8581.00
33_L36_L0.8331.00
11_G14_A0.7921.00
46_C49_C0.7881.00
11_G24_A0.7861.00
9_E13_A0.7801.00
16_G24_A0.7721.00
31_E35_R0.7641.00
5_G38_E0.7551.00
9_E14_A0.7521.00
32_L36_L0.7491.00
29_S33_L0.7471.00
9_E47_P0.7341.00
33_L37_P0.7281.00
23_C44_C0.7281.00
13_A43_D0.7251.00
3_R35_R0.6971.00
15_G22_W0.6961.00
37_P42_K0.6891.00
3_R8_F0.6841.00
2_P41_Y0.6401.00
22_W25_E0.6321.00
2_P45_L0.6291.00
36_L45_L0.6151.00
2_P7_P0.6001.00
37_P41_Y0.5981.00
44_C49_C0.5871.00
5_G10_C0.5761.00
26_V45_L0.5651.00
36_L41_Y0.5480.99
16_G20_P0.5470.99
31_E34_A0.5240.99
11_G20_P0.5210.99
28_L45_L0.5160.99
15_G25_E0.5050.99
11_G22_W0.5010.99
3_R40_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wnfA 1 0.1765 7.7 0.814 Contact Map
1s24A 1 0.3333 4.9 0.831 Contact Map
2y69F 1 0.2941 4.5 0.833 Contact Map
1v54F 2 0.3333 4.3 0.836 Contact Map
2v3bB 1 0.2941 4.2 0.836 Contact Map
3h2yA 1 0 3.1 0.846 Contact Map
1vx7a 1 0.8431 2.7 0.851 Contact Map
3t6pA 1 0.2941 2.6 0.851 Contact Map
2gmgA 1 0.6863 2.5 0.854 Contact Map
3u5eg 1 0.8431 2.4 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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