GREMLIN Database
DUF4410 - Domain of unknown function (DUF4410)
PFAM: PF14366 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 134 (132)
Sequences: 3038 (2212)
Seq/√Len: 192.6
META: 0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K87_A3.5351.00
68_Y97_E2.6681.00
126_T129_V2.5371.00
33_A52_R2.4481.00
35_L69_F2.4181.00
85_F125_V2.3741.00
5_D52_R2.2311.00
76_N79_K2.2261.00
70_L95_A2.1641.00
61_N100_Q1.9961.00
59_P62_D1.9931.00
43_L46_M1.9611.00
75_G86_G1.9291.00
34_A38_E1.9221.00
36_A52_R1.9111.00
7_A12_D1.8801.00
65_I98_V1.8661.00
105_L109_G1.7651.00
26_A30_K1.7461.00
38_E42_E1.7141.00
33_A37_E1.7051.00
37_E52_R1.6991.00
36_A40_V1.6461.00
21_T24_Q1.6241.00
64_V105_L1.6211.00
3_V40_V1.6151.00
69_F72_V1.5841.00
38_E41_A1.5531.00
93_K114_D1.5411.00
126_T130_G1.5341.00
104_G109_G1.5321.00
123_A126_T1.5261.00
40_V50_A1.5141.00
101_M105_L1.4331.00
110_S113_T1.4161.00
80_R88_G1.3781.00
20_Q25_I1.3751.00
127_L130_G1.3671.00
5_D36_A1.3421.00
28_G32_G1.3401.00
44_R49_P1.3291.00
105_L108_L1.3031.00
2_Y53_A1.2971.00
35_L94_T1.2941.00
111_F115_A1.2841.00
30_K34_A1.2801.00
42_E45_K1.2701.00
14_P17_S1.2591.00
94_T113_T1.2441.00
66_R99_Y1.2431.00
40_V52_R1.2411.00
41_A45_K1.2181.00
75_G85_F1.2051.00
91_E114_D1.1901.00
4_Y64_V1.1881.00
1_I48_L1.1811.00
13_V16_D1.1661.00
128_G131_A1.1601.00
41_A44_R1.1581.00
37_E41_A1.1541.00
40_V44_R1.1481.00
51_E57_T1.1301.00
31_L72_V1.1191.00
15_L18_G1.0981.00
125_V129_V1.0981.00
78_A82_V1.0971.00
6_F96_V1.0901.00
25_I28_G1.0861.00
106_R109_G1.0841.00
10_P13_V1.0571.00
73_D77_R1.0171.00
34_A37_E1.0071.00
12_D29_R0.9920.99
68_Y95_A0.9910.99
26_A29_R0.9600.99
124_A129_V0.9570.99
95_A110_S0.9420.99
123_A130_G0.9210.99
110_S114_D0.8930.99
49_P52_R0.8900.99
111_F114_D0.8820.99
74_E79_K0.8790.99
66_R97_E0.8750.99
104_G108_L0.8630.99
13_V18_G0.8600.99
21_T29_R0.8580.99
85_F88_G0.8540.98
104_G107_K0.8530.98
55_G66_R0.8500.98
39_L65_I0.8380.98
14_P18_G0.8370.98
4_Y7_A0.8350.98
85_F121_P0.8340.98
20_Q24_Q0.8340.98
54_S57_T0.8330.98
124_A128_G0.8310.98
92_L100_Q0.8270.98
75_G88_G0.8250.98
7_A68_Y0.8230.98
27_L30_K0.8190.98
44_R51_E0.8080.98
28_G31_L0.8000.98
23_E26_A0.7960.98
51_E55_G0.7940.98
112_T115_A0.7910.97
29_R32_G0.7860.97
93_K112_T0.7850.97
75_G80_R0.7710.97
79_K83_I0.7690.97
7_A13_V0.7670.97
123_A128_G0.7590.97
62_D101_M0.7420.96
89_A119_K0.7410.96
89_A117_S0.7370.96
39_L43_L0.7350.96
98_V111_F0.7350.96
4_Y66_R0.7310.96
100_Q106_R0.7280.96
62_D100_Q0.7270.96
9_S12_D0.7180.96
5_D54_S0.7120.95
8_A12_D0.7120.95
73_D79_K0.7060.95
3_V43_L0.7030.95
43_L48_L0.6980.95
64_V101_M0.6970.95
30_K33_A0.6960.95
8_A11_A0.6960.95
81_V123_A0.6940.95
125_V128_G0.6890.94
25_I29_R0.6880.94
27_L74_E0.6860.94
18_G78_A0.6790.94
116_G119_K0.6750.94
45_K54_S0.6660.93
60_G98_V0.6650.93
74_E77_R0.6650.93
9_S25_I0.6640.93
110_S115_A0.6580.93
65_I96_V0.6570.93
44_R48_L0.6470.92
2_Y51_E0.6400.92
113_T117_S0.6390.92
5_D33_A0.6390.92
80_R90_S0.6370.92
58_P61_N0.6370.92
73_D91_E0.6320.92
88_G122_G0.6310.91
41_A52_R0.6290.91
36_A43_L0.6250.91
31_L94_T0.6240.91
39_L46_M0.6220.91
95_A112_T0.6210.91
89_A116_G0.6160.90
8_A14_P0.6140.90
36_A67_G0.6140.90
31_L35_L0.6130.90
117_S120_M0.6100.90
124_A130_G0.6060.90
58_P101_M0.6050.90
84_G88_G0.6030.90
101_M106_R0.6020.89
79_K82_V0.6020.89
123_A127_L0.6010.89
86_G118_G0.6000.89
41_A107_K0.5980.89
40_V53_A0.5810.88
102_T105_L0.5780.88
22_A44_R0.5740.87
75_G90_S0.5720.87
10_P14_P0.5700.87
35_L70_L0.5690.87
1_I4_Y0.5620.86
34_A41_A0.5600.86
6_F36_A0.5590.86
55_G59_P0.5560.85
47_G50_A0.5510.85
29_R33_A0.5510.85
89_A118_G0.5440.84
3_V50_A0.5420.84
24_Q28_G0.5400.84
51_E54_S0.5340.83
74_E81_V0.5330.83
83_I88_G0.5300.83
4_Y8_A0.5280.82
3_V6_F0.5270.82
3_V39_L0.5260.82
123_A132_A0.5240.82
77_R81_V0.5200.81
32_G92_L0.5170.81
79_K89_A0.5110.80
9_S16_D0.5110.80
107_K110_S0.5090.80
17_S43_L0.5040.79
4_Y10_P0.5020.79
11_A14_P0.5010.79
89_A115_A0.5000.79
63_L98_V0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uv2A 3 0.9478 57.6 0.867 Contact Map
3w1eA 1 0.8955 44.4 0.877 Contact Map
2iqiA 1 0.9328 37.9 0.881 Contact Map
2miiA 1 0.6343 20.4 0.896 Contact Map
4hrvA 2 0.8134 13.9 0.904 Contact Map
4q6vA 1 0.6194 8.6 0.912 Contact Map
4ltoA 3 0.3134 4.8 0.922 Contact Map
3zyyX 2 0.8657 4.7 0.922 Contact Map
2mhjA 1 0.5299 4.1 0.925 Contact Map
2hqsA 2 0.8582 3.9 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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