GREMLIN Database
AAA_assoc - Domain associated at C-terminal with AAA
PFAM: PF14363 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (95)
Sequences: 1067 (759)
Seq/√Len: 77.9
META: 0.074

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_Y92_W4.3511.00
29_I45_A4.1201.00
12_K15_R3.2031.00
11_S15_R2.4841.00
28_V77_D2.1581.00
29_I47_A2.0821.00
18_F46_E2.0131.00
41_L72_L1.9601.00
22_S31_E1.9291.00
50_S73_V1.9101.00
42_Y95_L1.7291.00
11_S17_L1.6821.00
81_E92_W1.6541.00
33_D66_G1.6041.00
9_L20_F1.5961.00
14_S88_G1.5941.00
81_E94_T1.5931.00
53_I58_A1.5750.99
37_K40_E1.5390.99
40_E46_E1.4750.99
28_V60_R1.4590.99
26_T30_E1.4090.99
52_K55_P1.3860.99
7_D30_E1.3700.99
38_R43_D1.3700.99
20_F23_P1.3330.98
12_K74_L1.3300.98
63_A74_L1.2740.98
42_Y69_S1.2490.97
29_I90_K1.2250.97
2_P6_R1.2230.97
77_D80_E1.1970.97
3_P42_Y1.1870.96
68_K96_V1.1780.96
35_R64_S1.1650.96
6_R11_S1.1590.96
27_I41_L1.1530.96
31_E34_G1.1450.96
68_K71_S1.1270.95
66_G86_F1.1060.95
47_A71_S1.0940.94
1_L7_D1.0680.94
32_F80_E1.0460.93
69_S88_G1.0450.93
53_I61_L1.0370.93
66_G69_S1.0300.92
33_D62_K1.0000.91
33_D50_S0.9920.91
63_A86_F0.9900.91
43_D91_L0.9820.90
4_E7_D0.9810.90
42_Y94_T0.9750.90
10_F14_S0.9690.90
83_T92_W0.9580.89
41_L64_S0.9570.89
25_L61_L0.9420.89
1_L4_E0.9390.88
56_S60_R0.9380.88
48_Y84_D0.9370.88
38_R85_E0.9340.88
43_D65_K0.8980.86
73_V76_M0.8870.85
14_S21_F0.8800.85
30_E95_L0.8730.84
27_I77_D0.8620.84
15_R43_D0.8430.82
45_A61_L0.8430.82
41_L80_E0.8410.82
16_K29_I0.8200.81
43_D61_L0.8180.80
38_R47_A0.8150.80
42_Y73_V0.8150.80
26_T29_I0.7960.79
4_E8_Y0.7950.78
18_F32_F0.7840.77
5_L10_F0.7830.77
91_L95_L0.7830.77
8_Y26_T0.7740.77
27_I64_S0.7740.77
56_S90_K0.7740.77
32_F38_R0.7640.76
59_R78_D0.7620.75
25_L76_M0.7620.75
9_L78_D0.7610.75
69_S83_T0.7550.75
47_A50_S0.7510.74
56_S86_F0.7250.72
21_F32_F0.7250.72
30_E52_K0.7230.72
27_I47_A0.7210.71
17_L83_T0.7190.71
60_R77_D0.7160.71
3_P6_R0.7040.70
8_Y19_S0.7030.69
47_A67_K0.7030.69
32_F41_L0.6890.68
73_V95_L0.6880.68
45_A49_L0.6840.67
56_S65_K0.6740.66
37_K74_L0.6710.66
20_F91_L0.6610.65
58_A61_L0.6520.64
14_S19_S0.6450.63
58_A80_E0.6430.63
60_R63_A0.6340.61
39_N64_S0.6280.61
5_L18_F0.6220.60
52_K60_R0.6200.60
21_F49_L0.6190.60
27_I53_I0.6180.59
2_P44_A0.6160.59
50_S91_L0.6100.58
6_R74_L0.6070.58
47_A79_N0.6070.58
1_L22_S0.6060.58
71_S80_E0.5960.57
36_L51_T0.5860.55
45_A71_S0.5820.55
45_A78_D0.5790.55
46_E73_V0.5790.55
34_G95_L0.5780.54
46_E89_V0.5750.54
66_G79_N0.5700.53
16_K26_T0.5550.52
31_E67_K0.5540.51
51_T54_S0.5530.51
4_E47_A0.5470.51
9_L15_R0.5440.50
20_F83_T0.5370.49
62_K80_E0.5340.49
31_E88_G0.5320.49
29_I65_K0.5260.48
84_D96_V0.5260.48
71_S75_S0.5260.48
47_A89_V0.5180.47
70_K89_V0.5150.46
82_V89_V0.5130.46
7_D19_S0.5110.46
71_S89_V0.5090.46
3_P10_F0.5040.45
37_K96_V0.5030.45
16_K62_K0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wcqA 1 0.4124 5.9 0.919 Contact Map
3kq4B 1 0.9588 5 0.922 Contact Map
2ve7C 1 0.9278 4.8 0.922 Contact Map
3hr0A 2 0.8866 4.8 0.922 Contact Map
2a1rA 2 0.2268 4.4 0.923 Contact Map
1mkyA 1 0.3402 4.4 0.924 Contact Map
2khuA 1 0.1753 4.1 0.925 Contact Map
1ve0A 3 0.9072 3.8 0.926 Contact Map
1i7hA 1 0.4021 3.8 0.926 Contact Map
4orlA 1 0.9485 3.8 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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