GREMLIN Database
DUF4401 - Domain of unknown function (DUF4401)
PFAM: PF14351 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 312 (308)
Sequences: 1129 (982)
Seq/√Len: 56.0
META: 0.726

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_S110_H4.6731.00
246_G276_F4.2971.00
13_W63_Q4.1811.00
9_G63_Q3.9041.00
257_G269_G3.8111.00
289_L292_S3.2831.00
293_L296_L3.0351.00
41_G79_G3.0111.00
73_Q110_H2.9651.00
77_A94_L2.8311.00
98_A117_A2.7941.00
41_G72_G2.5301.00
73_Q98_A2.4781.00
38_L79_G2.4731.00
254_L269_G2.4271.00
182_G186_L2.3201.00
112_F173_G2.3191.00
122_L125_A2.2911.00
12_A60_F2.2541.00
38_L83_L2.2391.00
299_G303_L2.2271.00
179_L183_L2.1621.00
69_S73_Q2.1381.00
70_L74_A2.1271.00
281_Y288_L2.0981.00
13_W67_A2.0741.00
12_A63_Q2.0321.00
12_A105_M1.9881.00
39_V43_L1.9851.00
8_L11_G1.9731.00
293_L297_A1.9561.00
52_L107_N1.9331.00
175_L178_L1.9211.00
60_F63_Q1.9101.00
110_H114_S1.7980.99
102_A170_L1.7970.99
73_Q101_L1.7880.99
67_A71_A1.7700.99
208_L211_V1.7660.99
281_Y291_K1.7650.99
202_L210_L1.7370.99
101_L110_H1.7240.99
9_G13_W1.6680.99
121_A124_L1.6660.99
13_W69_S1.6500.99
66_L105_M1.6450.99
16_A67_A1.6440.99
257_G265_L1.6090.98
286_L290_T1.6030.98
23_L29_G1.6030.98
45_I72_G1.5970.98
287_T295_L1.5880.98
8_L12_A1.5850.98
290_T293_L1.5800.98
291_K295_L1.5670.98
122_L127_L1.5510.98
207_L210_L1.5480.98
131_L141_L1.5450.98
172_Y262_N1.5350.98
287_T292_S1.5300.98
5_R9_G1.5260.98
66_L111_R1.5230.98
179_L182_G1.5080.98
227_G231_L1.5040.98
246_G257_G1.4960.98
33_S36_G1.4870.97
272_A277_L1.4850.97
102_A173_G1.4790.97
122_L131_L1.4680.97
183_L188_G1.4620.97
102_A241_S1.4610.97
280_Y294_L1.4600.97
7_L11_G1.4390.97
283_D286_L1.4160.97
95_A118_A1.4140.97
297_A300_A1.4120.97
5_R59_L1.4080.96
18_F22_F1.4000.96
172_Y265_L1.3970.96
121_A125_A1.3860.96
173_G177_A1.3850.96
280_Y295_L1.3820.96
274_L277_L1.3590.96
182_G187_S1.3350.95
274_L278_S1.3350.95
67_A306_R1.3280.95
66_L98_A1.3280.95
10_F14_L1.3280.95
294_L298_S1.3000.94
23_L266_L1.2880.94
66_L107_N1.2870.94
199_S202_L1.2860.94
147_L151_L1.2820.94
148_A152_L1.2810.94
288_L295_L1.2800.94
36_G50_A1.2770.94
3_Y246_G1.2750.94
194_L197_W1.2700.94
13_W73_Q1.2610.93
123_L126_L1.2600.93
60_F65_A1.2540.93
274_L283_D1.2470.93
48_A111_R1.2440.93
69_S101_L1.2430.93
282_Y291_K1.2410.93
78_F82_E1.2390.93
74_A78_F1.2340.93
200_A208_L1.2300.93
277_L295_L1.2250.92
292_S303_L1.2240.92
40_L47_A1.2190.92
120_A125_A1.2140.92
43_L47_A1.2100.92
200_A209_A1.2080.92
135_L138_L1.2020.92
47_A50_A1.1940.91
125_A129_S1.1910.91
102_A118_A1.1840.91
303_L306_R1.1830.91
174_L197_W1.1790.91
250_A272_A1.1780.91
276_F283_D1.1740.91
197_W209_A1.1630.90
27_L31_L1.1600.90
168_R262_N1.1580.90
98_A110_H1.1520.90
25_L29_G1.1490.90
232_L235_L1.1490.90
3_Y8_L1.1460.90
121_A126_L1.1450.90
63_Q67_A1.1370.89
16_A64_L1.1260.89
197_W200_A1.1250.89
173_G279_A1.1240.89
203_L209_A1.1210.89
109_I112_F1.1210.89
214_L217_R1.1190.89
11_G243_F1.1100.88
98_A118_A1.0940.87
293_L304_A1.0880.87
76_L97_L1.0830.87
281_Y284_L1.0810.87
205_A210_L1.0750.87
249_A252_L1.0680.86
220_I227_G1.0640.86
279_A283_D1.0630.86
123_L129_S1.0590.86
66_L110_H1.0560.86
112_F176_L1.0500.85
12_A15_A1.0460.85
116_L268_L1.0460.85
121_A127_L1.0430.85
255_L258_F1.0420.85
69_S111_R1.0420.85
262_N306_R1.0420.85
13_W17_L1.0410.85
123_L128_L1.0320.84
215_L300_A1.0280.84
16_A70_L1.0250.84
275_Y279_A1.0230.84
224_S227_G1.0210.84
15_A60_F1.0050.83
3_Y6_L0.9920.82
12_A16_A0.9880.81
250_A269_G0.9790.81
254_L266_L0.9790.81
44_L71_A0.9780.81
127_L137_A0.9780.81
196_P199_S0.9760.81
8_L251_L0.9670.80
52_L65_A0.9650.80
46_A50_A0.9540.79
19_L23_L0.9530.79
13_W65_A0.9530.79
73_Q114_S0.9510.79
183_L187_S0.9500.79
198_A209_A0.9450.78
230_A254_L0.9410.78
108_F112_F0.9380.78
247_I273_L0.9350.78
196_P200_A0.9350.78
97_L162_R0.9270.77
272_A279_A0.9200.77
1_P9_G0.9110.76
67_A111_R0.9080.76
115_A170_L0.9070.76
288_L302_L0.9040.75
29_G33_S0.9040.75
244_A276_F0.8990.75
271_L274_L0.8950.75
12_A243_F0.8920.74
244_A247_I0.8900.74
7_L10_F0.8840.74
9_G12_A0.8840.74
287_T290_T0.8820.74
248_G252_L0.8790.73
250_A273_L0.8650.72
79_G261_G0.8630.72
251_L306_R0.8630.72
105_M114_S0.8600.72
3_Y7_L0.8570.71
11_G14_L0.8550.71
59_L247_I0.8540.71
148_A151_L0.8460.70
288_L291_K0.8460.70
89_A304_A0.8350.69
122_L129_S0.8330.69
205_A209_A0.8330.69
58_S264_V0.8290.69
209_A309_L0.8250.68
120_A131_L0.8160.68
173_G241_S0.8140.67
12_A248_G0.8110.67
103_L228_L0.8080.67
52_L102_A0.8050.67
74_A212_W0.8050.67
34_E37_A0.8040.66
181_L185_L0.7990.66
14_L45_I0.7940.65
221_K225_L0.7920.65
241_S245_P0.7890.65
235_L239_L0.7860.65
19_L24_G0.7830.64
204_A211_V0.7820.64
190_P201_L0.7820.64
299_G302_L0.7810.64
75_L79_G0.7810.64
42_L66_L0.7800.64
200_A203_L0.7800.64
13_W60_F0.7790.64
190_P193_A0.7770.64
172_Y277_L0.7760.64
37_A78_F0.7760.64
137_A141_L0.7750.64
112_F251_L0.7750.64
2_W13_W0.7740.63
39_V204_A0.7700.63
249_A268_L0.7670.63
13_W66_L0.7650.63
73_Q261_G0.7640.62
44_L178_L0.7630.62
280_Y291_K0.7600.62
48_A106_P0.7590.62
1_P4_V0.7580.62
290_T294_L0.7570.62
284_L291_K0.7550.62
208_L212_W0.7540.61
199_S206_L0.7540.61
68_L74_A0.7530.61
24_G34_E0.7530.61
177_A208_L0.7500.61
51_L82_E0.7490.61
241_S253_L0.7470.61
39_V42_L0.7450.60
102_A113_L0.7450.60
262_N270_I0.7440.60
115_A173_G0.7440.60
100_A300_A0.7420.60
123_L132_G0.7420.60
58_S262_N0.7410.60
99_L103_L0.7390.60
64_L140_L0.7380.60
65_A267_G0.7370.60
257_G260_R0.7370.60
196_P212_W0.7350.59
24_G31_L0.7300.59
123_L127_L0.7300.59
61_L64_L0.7280.59
15_A67_A0.7250.58
246_G250_A0.7250.58
21_G250_A0.7230.58
11_G265_L0.7220.58
120_A124_L0.7220.58
201_L211_V0.7200.58
123_L131_L0.7200.58
183_L186_L0.7190.58
272_A275_Y0.7180.58
272_A276_F0.7160.57
121_A131_L0.7160.57
20_L75_L0.7150.57
120_A126_L0.7140.57
214_L218_L0.7110.57
51_L68_L0.7110.57
32_D43_L0.7040.56
182_G188_G0.7040.56
39_V191_L0.7040.56
64_L74_A0.6960.55
29_G32_D0.6910.55
172_Y264_V0.6900.55
169_P182_G0.6900.55
70_L268_L0.6900.55
126_L129_S0.6890.55
163_R166_L0.6880.54
166_L169_P0.6870.54
241_S244_A0.6870.54
171_A257_G0.6860.54
145_L150_L0.6830.54
13_W16_A0.6830.54
198_A207_L0.6820.54
104_L117_A0.6800.54
21_G43_L0.6790.53
131_L138_L0.6780.53
209_A212_W0.6720.53
24_G127_L0.6720.53
284_L288_L0.6720.53
226_R233_A0.6700.53
10_F68_L0.6700.53
127_L130_G0.6680.52
148_A155_A0.6680.52
249_A257_G0.6660.52
112_F169_P0.6650.52
93_L235_L0.6650.52
216_K220_I0.6650.52
9_G173_G0.6620.52
137_A140_L0.6620.52
125_A136_I0.6610.52
3_Y67_A0.6590.51
273_L276_F0.6550.51
80_L90_L0.6540.51
275_Y278_S0.6540.51
167_L177_A0.6530.51
212_W223_P0.6510.50
123_L135_L0.6500.50
152_L208_L0.6500.50
281_Y292_S0.6500.50
126_L133_P0.6490.50
52_L276_F0.6460.50
43_L148_A0.6460.50
180_L187_S0.6440.50
285_D296_L0.6440.50
19_L31_L0.6430.50
106_P188_G0.6400.49
86_S90_L0.6400.49
23_L44_L0.6400.49
245_P298_S0.6400.49
70_L285_D0.6390.49
143_L148_A0.6380.49
96_L239_L0.6360.49
126_L141_L0.6360.49
84_L89_A0.6350.49
302_L307_W0.6330.49
75_L114_S0.6330.49
96_L220_I0.6330.49
106_P111_R0.6300.48
60_F245_P0.6300.48
133_P137_A0.6300.48
89_A212_W0.6290.48
125_A128_L0.6260.48
13_W110_H0.6230.47
17_L32_D0.6220.47
248_G253_L0.6130.46
229_L236_L0.6120.46
257_G266_L0.6110.46
62_E263_R0.6100.46
123_L300_A0.6080.46
76_L294_L0.6080.46
73_Q289_L0.6080.46
9_G60_F0.6070.46
64_L68_L0.6060.46
212_W220_I0.6030.45
58_S270_I0.6030.45
292_S299_G0.6020.45
16_A110_H0.6010.45
275_Y283_D0.6000.45
11_G79_G0.6000.45
51_L189_G0.5990.45
49_I170_L0.5980.45
8_L13_W0.5980.45
158_L169_P0.5970.45
66_L257_G0.5960.45
222_L228_L0.5950.44
270_I289_L0.5940.44
128_L203_L0.5930.44
138_L142_L0.5910.44
69_S114_S0.5890.44
291_K299_G0.5880.44
223_P226_R0.5860.43
48_A61_L0.5850.43
88_S169_P0.5840.43
41_G75_L0.5820.43
189_G192_F0.5820.43
42_L76_L0.5810.43
8_L19_L0.5790.43
9_G67_A0.5780.43
222_L227_G0.5770.42
283_D292_S0.5730.42
104_L254_L0.5730.42
161_A239_L0.5710.42
170_L173_G0.5700.42
7_L254_L0.5690.42
285_D301_L0.5680.42
73_Q105_M0.5650.41
22_F280_Y0.5650.41
265_L288_L0.5640.41
276_F292_S0.5640.41
71_A176_L0.5610.41
140_L144_A0.5600.41
121_A130_G0.5560.40
26_L37_A0.5560.40
10_F17_L0.5550.40
241_S247_I0.5550.40
190_P195_L0.5550.40
128_L149_L0.5540.40
199_S210_L0.5520.40
120_A123_L0.5510.40
32_D201_L0.5510.40
102_A115_A0.5500.40
64_L79_G0.5470.39
58_S263_R0.5470.39
10_F113_L0.5470.39
300_A304_A0.5470.39
37_A64_L0.5470.39
269_G306_R0.5440.39
18_F69_S0.5440.39
30_L33_S0.5420.39
3_Y18_F0.5390.39
131_L134_L0.5380.38
205_A229_L0.5380.38
78_F94_L0.5380.38
21_G207_L0.5370.38
67_A246_G0.5360.38
247_I283_D0.5350.38
158_L204_A0.5330.38
142_L165_A0.5320.38
8_L16_A0.5320.38
286_L294_L0.5320.38
247_I278_S0.5310.38
24_G40_L0.5310.38
249_A286_L0.5290.37
151_L154_E0.5290.37
194_L199_S0.5290.37
235_L286_L0.5280.37
169_P245_P0.5270.37
105_M272_A0.5270.37
257_G262_N0.5260.37
165_A201_L0.5250.37
195_L229_L0.5250.37
203_L207_L0.5240.37
24_G56_R0.5240.37
9_G26_L0.5230.37
60_F266_L0.5230.37
269_G276_F0.5200.37
57_K268_L0.5200.37
18_F71_A0.5200.37
180_L183_L0.5140.36
243_F248_G0.5130.36
141_L304_A0.5130.36
49_I105_M0.5110.36
76_L202_L0.5090.35
245_P282_Y0.5090.35
203_L206_L0.5090.35
48_A65_A0.5080.35
127_L133_P0.5050.35
110_H258_F0.5030.35
123_L130_G0.5030.35
138_L143_L0.5030.35
175_L253_L0.5030.35
12_A113_L0.5020.35
202_L205_A0.5020.35
5_R79_G0.5010.35
190_P194_L0.5000.35
67_A73_Q0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j01B 1 0.1731 11.4 0.947 Contact Map
2kv5A 1 0.1058 2.8 0.96 Contact Map
3l1lA 2 0.3622 2.7 0.96 Contact Map
4b19A 1 0.0962 2.3 0.962 Contact Map
2basA 2 0.1923 2 0.963 Contact Map
2k1aA 1 0.109 2 0.963 Contact Map
4p6vB 1 0.4455 1.7 0.965 Contact Map
2m3eA 1 0.1282 1.4 0.966 Contact Map
2xq2A 2 0.4712 1.3 0.967 Contact Map
2ksfA 1 0.3301 1.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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