GREMLIN Database
Beta_protein - Beta protein
PFAM: PF14350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 340 (336)
Sequences: 1624 (1490)
Seq/√Len: 81.3
META: 0.693

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_D192_R6.1161.00
4_I197_A5.5251.00
197_A240_G4.4741.00
24_D61_R3.7651.00
22_V336_T3.4781.00
126_G159_D3.4611.00
102_G105_R3.4131.00
200_S221_E3.3931.00
9_Q324_T3.3641.00
243_G331_T3.2961.00
15_L30_I3.0151.00
126_G192_R2.9961.00
101_I111_L2.8861.00
101_I105_R2.8411.00
2_V29_L2.7911.00
198_G221_E2.7711.00
128_A161_I2.7441.00
308_Q312_E2.7131.00
65_F128_A2.6151.00
7_W12_L2.6141.00
271_V292_L2.5361.00
244_I330_G2.4431.00
309_Y312_E2.3531.00
91_R122_D2.3411.00
305_W328_A2.3171.00
27_T65_F2.3151.00
67_D130_R2.2591.00
327_R331_T2.2171.00
216_E267_S2.1931.00
311_A315_N2.1851.00
304_S307_D2.1681.00
309_Y329_V2.1341.00
26_I335_L2.1331.00
226_K266_D2.0821.00
7_W30_I2.0781.00
2_V238_I2.0331.00
129_L144_I2.0151.00
261_R327_R2.0111.00
245_I327_R1.9871.00
322_N325_T1.9851.00
22_V339_V1.9811.00
259_K327_R1.9511.00
273_G284_Q1.9371.00
286_R316_G1.9081.00
17_E328_A1.8921.00
303_F307_D1.8921.00
2_V195_I1.8531.00
332_N336_T1.8131.00
293_V314_A1.7881.00
301_A311_A1.7681.00
19_S22_V1.7611.00
263_T268_W1.7251.00
299_R337_L1.6951.00
300_G303_F1.6741.00
321_G326_W1.6731.00
4_I31_E1.6661.00
18_L23_K1.6171.00
307_D333_H1.5691.00
6_K31_E1.5631.00
10_G331_T1.5551.00
18_L332_N1.5521.00
263_T333_H1.5461.00
160_L191_W1.5360.99
195_I240_G1.5070.99
29_L161_I1.4960.99
196_V228_L1.4830.99
3_P28_P1.4680.99
303_F336_T1.4610.99
286_R320_T1.4610.99
263_T337_L1.4610.99
262_Y292_L1.4560.99
18_L336_T1.4520.99
300_G307_D1.4370.99
128_A197_A1.4240.99
64_F95_L1.4190.99
201_F268_W1.4160.99
255_R275_S1.4130.99
313_C329_V1.4050.99
4_I240_G1.4050.99
276_V282_F1.4020.99
65_F159_D1.3980.99
222_W225_W1.3940.99
321_G325_T1.3930.99
239_F268_W1.3900.99
12_L53_R1.3810.99
195_I238_I1.3550.99
256_P323_P1.3460.99
159_D193_S1.3260.98
194_I237_P1.3240.98
65_F100_V1.2990.98
36_K39_P1.2950.98
258_P285_Y1.2900.98
9_Q12_L1.2850.98
159_D195_I1.2790.98
258_P276_V1.2710.98
312_E317_T1.2700.98
127_V158_V1.2660.98
259_K288_L1.2640.98
311_A314_A1.2600.98
285_Y323_P1.2560.98
9_Q13_K1.2550.98
18_L26_I1.2530.98
331_T335_L1.2400.98
16_E56_K1.2290.97
10_G324_T1.2230.97
301_A315_N1.2200.97
325_T328_A1.2150.97
65_F193_S1.2150.97
131_L135_D1.2060.97
183_L194_I1.1960.97
305_W332_N1.1950.97
75_L81_H1.1880.97
122_D125_R1.1800.97
327_R330_G1.1760.97
111_L114_V1.1750.97
306_G332_N1.1650.97
30_I64_F1.1630.96
127_V153_L1.1600.96
193_S238_I1.1450.96
6_K197_A1.1410.96
262_Y307_D1.1400.96
245_I331_T1.1400.96
90_L95_L1.1340.96
324_T328_A1.1320.96
18_L32_L1.1280.96
307_D332_N1.1260.96
269_L297_E1.1240.96
260_I288_L1.1180.96
245_I259_K1.1120.95
105_R111_L1.1080.95
64_F97_A1.1040.95
31_E130_R1.1000.95
132_R135_D1.0910.95
103_L135_D1.0820.95
299_R333_H1.0820.95
320_T326_W1.0790.95
282_F320_T1.0770.95
205_L259_K1.0730.94
292_L295_S1.0700.94
281_G284_Q1.0700.94
260_I289_A1.0700.94
201_F261_R1.0680.94
8_K321_G1.0630.94
201_F246_H1.0570.94
201_F257_S1.0510.94
130_R163_D1.0510.94
147_L151_L1.0490.94
68_L83_L1.0470.94
42_T45_E1.0390.93
17_E305_W1.0340.93
333_H338_V1.0280.93
276_V323_P1.0240.93
293_V311_A1.0200.93
336_T339_V1.0140.93
262_Y300_G1.0110.92
310_I329_V1.0090.92
115_V119_A1.0070.92
13_K16_E1.0060.92
81_H85_E1.0050.92
325_T329_V1.0030.92
271_V291_R0.9980.92
141_E145_E0.9970.92
1_Y5_L0.9960.92
259_K330_G0.9950.92
13_K17_E0.9950.92
98_I128_A0.9900.92
91_R125_R0.9820.91
305_W308_Q0.9790.91
164_L196_V0.9770.91
23_K59_G0.9760.91
290_K294_A0.9750.91
215_G272_R0.9720.91
89_L92_A0.9690.91
275_S279_G0.9690.91
48_D52_K0.9690.91
19_S336_T0.9630.91
165_G248_E0.9610.90
306_G329_V0.9570.90
2_V27_T0.9540.90
222_W338_V0.9520.90
319_G322_N0.9520.90
16_E53_R0.9520.90
23_K58_W0.9440.90
219_R307_D0.9400.89
313_C316_G0.9350.89
29_L65_F0.9330.89
293_V298_F0.9310.89
287_D291_R0.9240.89
285_Y289_A0.9220.89
274_R280_D0.9060.88
161_I240_G0.9060.88
187_P191_W0.9060.88
53_R56_K0.9040.88
7_W33_P0.9040.88
261_R330_G0.9030.88
323_P327_R0.9010.87
1_Y28_P0.8950.87
100_V130_R0.8940.87
101_I114_V0.8910.87
173_D296_P0.8880.87
2_V65_F0.8880.87
193_S330_G0.8870.87
301_A308_Q0.8860.87
110_Y113_A0.8850.86
20_P24_D0.8790.86
326_W329_V0.8790.86
3_P26_I0.8790.86
285_Y329_V0.8770.86
4_I29_L0.8690.85
205_L272_R0.8650.85
289_A327_R0.8640.85
203_K248_E0.8590.85
259_K289_A0.8550.84
221_E268_W0.8500.84
300_G333_H0.8500.84
330_G333_H0.8490.84
218_P267_S0.8490.84
208_I215_G0.8470.84
220_L223_L0.8450.84
65_F161_I0.8440.84
252_G257_S0.8420.84
298_F304_S0.8400.83
174_A178_A0.8340.83
258_P323_P0.8330.83
72_P75_L0.8300.83
303_F333_H0.8280.83
201_F205_L0.8280.83
143_D147_L0.8250.82
110_Y114_V0.8240.82
18_L22_V0.8200.82
1_Y11_E0.8150.82
219_R261_R0.8140.81
304_S336_T0.8130.81
201_F259_K0.8120.81
30_I54_L0.8110.81
12_L57_A0.8090.81
216_E269_L0.8020.81
302_D308_Q0.7970.80
304_S333_H0.7900.80
52_K56_K0.7880.79
219_R222_W0.7880.79
8_K327_R0.7870.79
217_I272_R0.7860.79
8_K219_R0.7850.79
258_P281_G0.7850.79
178_A181_A0.7840.79
10_G328_A0.7830.79
111_L115_V0.7820.79
245_I261_R0.7810.79
310_I326_W0.7800.79
205_L209_G0.7800.79
70_L73_D0.7770.78
6_K11_E0.7760.78
199_T275_S0.7690.78
258_P284_Q0.7660.77
1_Y8_K0.7650.77
167_V171_D0.7610.77
263_T307_D0.7600.77
244_I327_R0.7580.77
130_R242_Y0.7570.77
108_D207_G0.7550.76
308_Q311_A0.7540.76
244_I263_T0.7510.76
34_P285_Y0.7510.76
244_I259_K0.7500.76
87_F260_I0.7490.76
263_T338_V0.7480.76
276_V285_Y0.7470.76
212_D274_R0.7440.75
87_F97_A0.7430.75
20_P61_R0.7380.75
171_D225_W0.7340.74
34_P245_I0.7340.74
142_A146_A0.7330.74
327_R333_H0.7290.74
219_R270_I0.7260.74
129_L148_L0.7240.73
249_Y327_R0.7220.73
151_L158_V0.7220.73
27_T238_I0.7200.73
105_R110_Y0.7190.73
306_G333_H0.7180.73
313_C320_T0.7150.72
219_R263_T0.7140.72
205_L217_I0.7130.72
289_A306_G0.7120.72
6_K272_R0.7090.72
58_W61_R0.7080.72
54_L58_W0.7070.72
257_S272_R0.7060.71
13_K328_A0.7020.71
172_A175_L0.7010.71
148_L155_P0.6970.70
260_I305_W0.6970.70
143_D180_R0.6930.70
254_G275_S0.6910.70
223_L226_K0.6890.70
214_T269_L0.6870.69
284_Q288_L0.6860.69
5_L11_E0.6830.69
29_L100_V0.6810.69
259_K285_Y0.6800.69
35_E49_K0.6790.68
292_L297_E0.6790.68
27_T98_I0.6770.68
58_W98_I0.6730.68
118_I150_A0.6730.68
150_A180_R0.6710.68
288_L291_R0.6710.68
6_K242_Y0.6700.67
272_R279_G0.6690.67
75_L106_D0.6660.67
183_L186_L0.6660.67
15_L58_W0.6660.67
259_K273_G0.6640.67
66_L90_L0.6610.66
219_R262_Y0.6610.66
52_K93_A0.6580.66
189_L235_R0.6560.66
112_A116_A0.6560.66
244_I331_T0.6560.66
149_A317_T0.6560.66
243_G327_R0.6550.66
258_P275_S0.6550.66
27_T159_D0.6550.66
171_D227_A0.6540.66
219_R225_W0.6540.66
320_T325_T0.6500.65
244_I261_R0.6490.65
264_T267_S0.6440.64
37_R40_K0.6440.64
290_K316_G0.6440.64
309_Y325_T0.6420.64
303_F338_V0.6400.64
49_K54_L0.6360.63
112_A115_V0.6360.63
89_L93_A0.6350.63
42_T46_H0.6350.63
269_L292_L0.6340.63
228_L232_A0.6340.63
253_G272_R0.6330.63
90_L97_A0.6330.63
119_A123_G0.6330.63
257_S288_L0.6320.63
7_W50_F0.6320.63
199_T246_H0.6310.63
16_E55_A0.6310.63
173_D186_L0.6310.63
88_E121_R0.6270.62
219_R334_H0.6270.62
300_G304_S0.6230.62
260_I313_C0.6210.62
289_A313_C0.6190.61
8_K34_P0.6190.61
78_D157_E0.6150.61
67_D100_V0.6150.61
8_K11_E0.6140.61
45_E278_K0.6140.61
32_L56_K0.6140.61
83_L87_F0.6140.61
34_P327_R0.6140.61
307_D311_A0.6120.60
47_L128_A0.6120.60
81_H113_A0.6100.60
4_I128_A0.6080.60
219_R304_S0.6080.60
10_G219_R0.6050.60
298_F307_D0.6050.60
304_S321_G0.6050.60
307_D314_A0.6050.60
116_A156_E0.6040.59
98_I142_A0.6040.59
8_K324_T0.6030.59
200_S268_W0.6020.59
56_K139_D0.6010.59
202_P327_R0.6000.59
61_R64_F0.5990.59
31_E242_Y0.5980.59
219_R244_I0.5980.59
191_W330_G0.5970.59
310_I332_N0.5960.58
14_A247_P0.5960.58
259_K270_I0.5960.58
288_L292_L0.5950.58
11_E15_L0.5940.58
214_T291_R0.5940.58
161_I197_A0.5940.58
172_A179_I0.5910.58
5_L243_G0.5900.58
262_Y333_H0.5870.57
199_T221_E0.5870.57
212_D257_S0.5870.57
128_A132_R0.5860.57
161_I195_I0.5840.57
27_T30_I0.5830.57
160_L207_G0.5820.57
38_K150_A0.5820.57
180_R184_A0.5810.57
87_F118_I0.5810.57
4_I94_G0.5800.56
249_Y285_Y0.5790.56
175_L224_L0.5790.56
218_P223_L0.5770.56
245_I330_G0.5760.56
268_W272_R0.5740.56
257_S261_R0.5740.56
56_K134_E0.5720.55
147_L272_R0.5710.55
138_P240_G0.5700.55
290_K293_V0.5700.55
20_P339_V0.5690.55
260_I292_L0.5690.55
21_A294_A0.5690.55
254_G272_R0.5690.55
270_I323_P0.5670.55
184_A187_P0.5660.55
328_A332_N0.5660.55
288_L313_C0.5660.55
27_T193_S0.5660.55
82_P101_I0.5650.54
10_G327_R0.5640.54
11_E333_H0.5640.54
55_A60_G0.5640.54
52_K190_G0.5640.54
310_I330_G0.5640.54
163_D242_Y0.5630.54
118_I153_L0.5630.54
21_A296_P0.5620.54
205_L330_G0.5610.54
176_A179_I0.5600.54
119_A141_E0.5580.54
313_C318_A0.5570.53
168_D171_D0.5550.53
9_Q57_A0.5540.53
262_Y303_F0.5500.53
273_G288_L0.5490.52
264_T299_R0.5480.52
198_G239_F0.5470.52
207_G311_A0.5470.52
244_I249_Y0.5470.52
208_I217_I0.5470.52
228_L237_P0.5470.52
132_R165_G0.5460.52
56_K149_A0.5440.52
242_Y307_D0.5440.52
199_T245_I0.5440.52
230_R233_L0.5440.52
71_D74_E0.5440.52
160_L190_G0.5420.51
35_E38_K0.5410.51
72_P76_T0.5380.51
116_A119_A0.5380.51
39_P45_E0.5370.51
152_G190_G0.5360.51
223_L266_D0.5350.51
126_G335_L0.5350.51
281_G285_Y0.5340.50
69_L132_R0.5320.50
9_Q53_R0.5300.50
66_L98_I0.5290.50
144_I162_L0.5290.50
20_P142_A0.5280.50
54_L124_F0.5280.50
50_F66_L0.5280.50
100_V161_I0.5270.50
309_Y320_T0.5260.49
254_G257_S0.5240.49
182_L186_L0.5240.49
100_V128_A0.5230.49
65_F68_L0.5230.49
127_V201_F0.5230.49
59_G95_L0.5220.49
194_I278_K0.5210.49
126_G157_E0.5200.49
29_L130_R0.5180.48
261_R273_G0.5170.48
111_L116_A0.5160.48
249_Y331_T0.5150.48
55_A162_L0.5150.48
276_V281_G0.5140.48
145_E148_L0.5140.48
145_E161_I0.5130.48
41_K45_E0.5130.48
14_A30_I0.5130.48
299_R303_F0.5130.48
301_A312_E0.5130.48
86_L282_F0.5120.48
41_K86_L0.5110.47
39_P42_T0.5100.47
54_L61_R0.5100.47
83_L90_L0.5100.47
51_A54_L0.5090.47
194_I235_R0.5080.47
88_E91_R0.5070.47
84_E94_G0.5070.47
257_S323_P0.5060.47
19_S45_E0.5060.47
141_E196_V0.5040.47
83_L86_L0.5030.46
26_I162_L0.5020.46
326_W333_H0.5010.46
232_A296_P0.5000.46
249_Y270_I0.5000.46
176_A180_R0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n4sA 2 0.1353 19 0.96 Contact Map
2x49A 1 0.3529 9.4 0.965 Contact Map
2hzmB 1 0.1647 7.5 0.967 Contact Map
2q2kA 3 0.1324 6.8 0.967 Contact Map
2lusA 1 0.3941 5.5 0.969 Contact Map
4fyuA 3 0.4029 5.4 0.969 Contact Map
3ayhA 1 0.1588 3.4 0.971 Contact Map
1th8B 1 0.3382 3.4 0.971 Contact Map
1xk7A 2 0.4588 3.3 0.972 Contact Map
2yimA 2 0.3824 3.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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