GREMLIN Database
DUF4399 - Domain of unknown function (DUF4399)
PFAM: PF14347 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (85)
Sequences: 8034 (4634)
Seq/√Len: 502.6
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D45_H3.4311.00
28_D64_H2.9441.00
5_L8_M2.8531.00
26_L29_T2.7691.00
16_D73_G2.5321.00
24_H75_H2.5051.00
39_I45_H2.1731.00
11_A20_T1.9101.00
34_P37_Q1.7951.00
72_D76_V1.7411.00
10_V51_G1.7311.00
2_R54_E1.6461.00
11_A17_K1.6401.00
29_T45_H1.5901.00
29_T44_N1.5781.00
3_F48_F1.5681.00
30_D86_K1.5481.00
9_G20_T1.5391.00
43_D46_L1.4951.00
23_H68_L1.4871.00
67_Q86_K1.4561.00
48_F55_T1.3571.00
69_L83_M1.3451.00
29_T32_P1.3371.00
17_K20_T1.3351.00
60_P64_H1.2721.00
60_P63_K1.2651.00
27_I57_L1.2561.00
46_L55_T1.2381.00
65_T86_K1.2181.00
78_H81_P1.1841.00
38_P76_V1.1581.00
8_M70_L1.1471.00
26_L69_L1.1451.00
27_I46_L1.1301.00
8_M82_V1.1261.00
26_L32_P1.1211.00
11_A15_V1.1161.00
32_P69_L1.0851.00
31_L67_Q1.0401.00
5_L9_G1.0401.00
30_D65_T1.0401.00
3_F68_L1.0061.00
35_L81_P0.9781.00
79_D82_V0.9761.00
9_G17_K0.9691.00
31_L83_M0.9541.00
26_L39_I0.9531.00
5_L10_V0.9491.00
2_R6_E0.9381.00
28_D60_P0.9341.00
48_F68_L0.9301.00
12_P15_V0.9281.00
69_L78_H0.9171.00
41_A46_L0.9121.00
16_D74_N0.9121.00
29_T42_D0.9121.00
27_I66_L0.9071.00
27_I59_L0.9061.00
22_H75_H0.9051.00
23_H70_L0.8921.00
83_M86_K0.8531.00
17_K50_K0.8281.00
49_G75_H0.8241.00
5_L70_L0.8201.00
35_L69_L0.8111.00
47_H75_H0.8061.00
78_H82_V0.8041.00
39_I42_D0.7861.00
69_L77_P0.7801.00
49_G52_Q0.7781.00
43_D58_T0.7731.00
35_L83_M0.7591.00
22_H68_L0.7521.00
15_V73_G0.7331.00
71_G75_H0.7281.00
26_L31_L0.7261.00
16_D20_T0.7261.00
26_L45_H0.7191.00
10_V23_H0.7141.00
38_P41_A0.6901.00
4_G23_H0.6891.00
24_H49_G0.6871.00
25_L66_L0.6781.00
21_G70_L0.6731.00
10_V53_T0.6731.00
17_K73_G0.6721.00
72_D78_H0.6691.00
48_F52_Q0.6681.00
24_H71_G0.6661.00
39_I69_L0.6611.00
41_A50_K0.6601.00
9_G15_V0.6581.00
52_Q55_T0.6531.00
31_L39_I0.6461.00
21_G72_D0.6381.00
23_H53_T0.6321.00
3_F25_L0.6251.00
46_L57_L0.6211.00
55_T58_T0.6111.00
3_F11_A0.6111.00
15_V18_P0.6090.99
47_H51_G0.6080.99
76_V79_D0.6070.99
31_L80_P0.5840.99
28_D44_N0.5750.99
79_D85_K0.5740.99
16_D72_D0.5730.99
36_G79_D0.5690.99
6_E9_G0.5690.99
55_T68_L0.5660.99
12_P50_K0.5650.99
11_A19_N0.5550.99
4_G9_G0.5550.99
43_D60_P0.5410.99
39_I71_G0.5390.99
9_G12_P0.5390.99
9_G19_N0.5360.99
79_D86_K0.5280.99
80_P83_M0.5260.99
5_L23_H0.5250.99
32_P45_H0.5230.98
15_V19_N0.5200.98
24_H47_H0.5190.98
10_V13_A0.5180.98
2_R56_T0.5080.98
37_Q74_N0.5040.98
11_A16_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4crrA 1 0.8736 46.3 0.845 Contact Map
4xvhA 1 0.8851 40.3 0.85 Contact Map
3ottA 2 0.977 39 0.851 Contact Map
3nqhA 2 0.8966 35.5 0.854 Contact Map
1uxzA 1 0.8966 34 0.856 Contact Map
2waoA 1 0.8851 33.6 0.856 Contact Map
2waaA 1 0.8966 32.3 0.858 Contact Map
3c7fA 1 0.8736 30.8 0.859 Contact Map
4e9lA 1 0.977 30.4 0.859 Contact Map
1cwvA 1 0.908 30.1 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.