GREMLIN Database
GDYXXLXY - GDYXXLXY protein
PFAM: PF14345 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (145)
Sequences: 5556 (4732)
Seq/√Len: 393.0
META: 0.853

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E45_E3.8731.00
21_E136_E3.4441.00
138_R148_K2.9811.00
33_D36_R2.6471.00
14_R18_T2.5911.00
69_K79_A2.4521.00
120_K123_E2.4171.00
32_R38_D2.4051.00
10_A14_R2.3481.00
140_D144_R2.3371.00
7_G11_Q2.3161.00
135_A147_L2.2621.00
122_R125_E2.0171.00
21_E138_R1.9601.00
116_V121_A1.9171.00
22_V96_V1.8871.00
136_E149_G1.8471.00
38_D121_A1.8061.00
20_T96_V1.7771.00
117_P120_K1.7011.00
67_V80_R1.6641.00
24_L46_I1.6631.00
36_R115_F1.6461.00
63_T99_R1.6311.00
16_L148_K1.6151.00
38_D119_G1.6151.00
24_L137_V1.6141.00
13_E17_A1.6001.00
23_L136_E1.5801.00
40_V116_V1.5761.00
92_P95_E1.5351.00
111_I137_V1.4801.00
71_D77_R1.4751.00
75_V134_Y1.4321.00
59_R62_D1.4221.00
15_I146_V1.4031.00
44_Y111_I1.3981.00
121_A125_E1.3801.00
33_D113_R1.3721.00
3_A7_G1.3721.00
26_T42_L1.3691.00
21_E148_K1.3511.00
58_L62_D1.3331.00
116_V124_Y1.3281.00
43_R48_R1.3181.00
136_E148_K1.2941.00
82_S85_P1.2941.00
91_L95_E1.2861.00
137_V145_A1.2621.00
96_V139_V1.2611.00
66_V78_A1.2531.00
64_V100_G1.2401.00
122_R126_R1.2161.00
123_E126_R1.2141.00
82_S97_Y1.1761.00
70_L76_A1.1571.00
86_P92_P1.1531.00
62_D83_R1.1521.00
108_R112_E1.1391.00
23_L134_Y1.1381.00
5_L8_M1.1281.00
13_E16_L1.1231.00
44_Y135_A1.1201.00
12_K15_I1.1201.00
8_M12_K1.1181.00
2_L6_A1.1041.00
9_I13_E1.0911.00
66_V81_V1.0791.00
100_G107_V1.0671.00
65_Y85_P1.0591.00
12_K146_V1.0451.00
69_K77_R1.0361.00
20_T70_L1.0341.00
6_A10_A1.0311.00
67_V82_S1.0271.00
65_Y97_Y1.0261.00
22_V76_A1.0161.00
128_L133_L0.9951.00
27_A45_E0.9941.00
61_G64_V0.9931.00
69_K95_E0.9881.00
92_P97_Y0.9781.00
38_D122_R0.9751.00
38_D118_E0.9741.00
47_S112_E0.9741.00
67_V95_E0.9721.00
29_V41_A0.9591.00
111_I145_A0.9511.00
27_A43_R0.9491.00
30_D39_Y0.9391.00
66_V109_Y0.9361.00
85_P97_Y0.9331.00
12_K144_R0.8971.00
22_V139_V0.8921.00
15_I19_G0.8741.00
38_D116_V0.8571.00
25_E75_V0.8561.00
46_I109_Y0.8531.00
127_A131_G0.8501.00
11_Q15_I0.8501.00
71_D75_V0.8491.00
44_Y112_E0.8441.00
101_R105_G0.8411.00
64_V67_V0.8361.00
25_E132_A0.8361.00
43_R106_R0.8351.00
8_M11_Q0.8341.00
102_V105_G0.8271.00
138_R146_V0.8221.00
110_G145_A0.7991.00
67_V97_Y0.7981.00
15_I140_D0.7951.00
79_A84_E0.7871.00
27_A48_R0.7821.00
18_T141_P0.7711.00
71_D74_G0.7711.00
126_R129_R0.7651.00
25_E133_L0.7621.00
123_E127_A0.7591.00
6_A9_I0.7561.00
98_L145_A0.7551.00
79_A82_S0.7551.00
24_L76_A0.7401.00
96_V100_G0.7391.00
26_T135_A0.7371.00
67_V91_L0.7321.00
127_A132_A0.7291.00
43_R47_S0.7281.00
64_V107_V0.7251.00
44_Y110_G0.7201.00
65_Y99_R0.7201.00
78_A82_S0.7181.00
41_A112_E0.7181.00
4_V8_M0.7161.00
11_Q144_R0.7101.00
28_P42_L0.7081.00
49_L52_L0.7081.00
28_P44_Y0.7051.00
38_D117_P0.6971.00
128_L131_G0.6911.00
38_D120_K0.6900.99
30_D34_L0.6820.99
114_Y149_G0.6750.99
33_D115_F0.6750.99
80_R95_E0.6720.99
124_Y133_L0.6710.99
126_R130_E0.6700.99
114_Y135_A0.6690.99
103_R108_R0.6680.99
52_L55_D0.6590.99
99_R144_R0.6550.99
80_R83_R0.6530.99
36_R113_R0.6520.99
58_L61_G0.6510.99
31_P39_Y0.6500.99
31_P37_G0.6490.99
116_V120_K0.6450.99
20_T74_G0.6410.99
78_A81_V0.6410.99
101_R104_G0.6370.99
19_G138_R0.6300.99
24_L47_S0.6250.99
40_V121_A0.6240.99
32_R119_G0.6170.99
68_L76_A0.6110.99
109_Y112_E0.6090.99
120_K124_Y0.6080.99
55_D58_L0.6060.99
29_V43_R0.6050.99
25_E134_Y0.5970.99
86_P91_L0.5960.99
26_T128_L0.5950.99
94_G98_L0.5950.99
51_P57_D0.5920.98
48_R106_R0.5900.98
15_I144_R0.5860.98
3_A13_E0.5830.98
8_M15_I0.5820.98
65_Y86_P0.5800.98
54_G58_L0.5790.98
9_I16_L0.5780.98
67_V86_P0.5740.98
40_V125_E0.5690.98
22_V137_V0.5620.98
36_R133_L0.5590.98
111_I135_A0.5580.98
127_A130_E0.5550.98
23_L73_D0.5540.98
82_S86_P0.5530.98
124_Y127_A0.5500.98
12_K16_L0.5490.98
116_V119_G0.5440.97
40_V122_R0.5420.97
41_A113_R0.5400.97
68_L145_A0.5360.97
49_L54_G0.5360.97
116_V122_R0.5350.97
7_G10_A0.5340.97
107_V112_E0.5340.97
47_S109_Y0.5340.97
139_V145_A0.5290.97
40_V118_E0.5210.97
114_Y150_L0.5210.97
72_A77_R0.5210.97
58_L83_R0.5200.97
4_V12_K0.5190.97
14_R141_P0.5180.96
22_V98_L0.5110.96
76_A79_A0.5110.96
2_L5_L0.5110.96
91_L94_G0.5100.96
9_I12_K0.5100.96
51_P54_G0.5070.96
16_L147_L0.5060.96
26_T40_V0.5050.96
70_L96_V0.5020.96
9_I15_I0.5000.96
27_A132_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d8kA 1 0.6667 5.8 0.93 Contact Map
4mzuA 5 0.34 5.2 0.932 Contact Map
3k6oA 1 0.8267 4.6 0.934 Contact Map
4m8rA 4 0.88 3.9 0.936 Contact Map
3k0yA 1 0.7733 3.6 0.937 Contact Map
1wltA 2 0.4467 3 0.939 Contact Map
1k9aA 2 0.7667 2.7 0.941 Contact Map
5buvA 2 0.42 2.7 0.941 Contact Map
3qwnA 4 0.7733 2.7 0.941 Contact Map
4jr2A 2 0.3933 2.4 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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