GREMLIN Database
DUF4397 - Domain of unknown function (DUF4397)
PFAM: PF14344 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (117)
Sequences: 20446 (16118)
Seq/√Len: 1490.1
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_R73_A3.0841.00
20_N44_Y3.0521.00
79_V88_L3.0121.00
69_A72_T2.7351.00
18_Y23_L2.6701.00
72_T91_T2.6121.00
2_R38_S2.3451.00
25_L28_V2.0951.00
23_L26_S2.0881.00
43_T67_T2.0791.00
29_A32_T2.0361.00
69_A74_Y1.9571.00
45_T63_S1.9471.00
6_V33_A1.9171.00
18_Y49_R1.8721.00
75_T92_D1.8211.00
9_S85_L1.7331.00
73_A94_L1.7081.00
14_A29_A1.6381.00
57_G60_V1.6001.00
50_P53_T1.5881.00
93_D103_R1.5731.00
49_R53_T1.5141.00
45_T65_T1.5061.00
19_V46_V1.5051.00
76_V89_V1.4971.00
77_V90_L1.4711.00
25_L34_S1.4411.00
47_A63_S1.4341.00
19_V24_V1.4171.00
43_T65_T1.4081.00
9_S80_G1.3761.00
77_V109_A1.3581.00
76_V87_L1.3261.00
79_V86_T1.3121.00
9_S12_A1.3051.00
14_A27_N1.3011.00
36_Y75_T1.2881.00
8_A109_A1.2761.00
79_V109_A1.2531.00
6_V77_V1.2481.00
80_G86_T1.2331.00
4_R36_Y1.1821.00
88_L107_V1.1751.00
98_A101_K1.1651.00
19_V44_Y1.1551.00
3_V76_V1.1551.00
21_G47_A1.1541.00
36_Y92_D1.1341.00
5_V17_V1.1271.00
7_H12_A1.1241.00
40_P44_Y1.1131.00
16_D27_N1.1081.00
94_L103_R1.1071.00
79_V107_V1.0901.00
74_Y89_V1.0531.00
18_Y47_A1.0491.00
97_P100_G1.0331.00
54_T58_T1.0311.00
62_L65_T1.0281.00
6_V75_T1.0211.00
16_D23_L1.0191.00
46_V66_V1.0031.00
56_A59_P0.9991.00
39_V44_Y0.9961.00
90_L107_V0.9941.00
110_S113_A0.9891.00
4_R33_A0.9871.00
106_V118_V0.9711.00
97_P103_R0.9681.00
11_D81_T0.9671.00
25_L37_L0.9421.00
81_T84_A0.9311.00
98_A103_R0.9241.00
41_A70_A0.9211.00
48_V78_A0.9111.00
92_D105_R0.9031.00
49_R54_T0.8961.00
28_V32_T0.8771.00
74_Y91_T0.8741.00
4_R35_G0.8591.00
4_R34_S0.8591.00
54_T59_P0.8561.00
12_A15_V0.8431.00
17_V48_V0.8411.00
113_A116_V0.8401.00
108_H113_A0.8251.00
24_V37_L0.8211.00
80_G84_A0.8041.00
49_R52_G0.7951.00
110_S114_P0.7861.00
11_D82_A0.7861.00
49_R59_P0.7721.00
95_T103_R0.7651.00
93_D97_P0.7631.00
2_R36_Y0.7571.00
8_A77_V0.7521.00
62_L87_L0.7501.00
47_A62_L0.7491.00
54_T57_G0.7471.00
4_R75_T0.7431.00
67_T70_A0.7381.00
80_G85_L0.7381.00
78_A85_L0.7261.00
26_S51_A0.7261.00
41_A44_Y0.7241.00
26_S52_G0.7231.00
86_T89_V0.7211.00
45_T62_L0.7181.00
11_D80_G0.7171.00
28_V34_S0.7141.00
18_Y57_G0.7071.00
49_R60_V0.7041.00
96_A101_K0.7041.00
36_Y73_A0.7011.00
7_H15_V0.6921.00
19_V39_V0.6881.00
68_L74_Y0.6811.00
46_V68_L0.6801.00
7_H78_A0.6691.00
80_G83_G0.6611.00
112_D115_A0.6561.00
90_L105_R0.6561.00
56_A60_V0.6541.00
77_V107_V0.6521.00
93_D96_A0.6501.00
7_H30_F0.6491.00
103_R106_V0.6391.00
87_L90_L0.6381.00
53_T57_G0.6371.00
21_G24_V0.6331.00
39_V68_L0.6321.00
63_S66_V0.6271.00
7_H13_P0.6211.00
96_A103_R0.6201.00
13_P82_A0.6181.00
89_V92_D0.6161.00
73_A92_D0.6161.00
86_T90_L0.6151.00
34_S37_L0.6001.00
16_D51_A0.5951.00
9_S78_A0.5921.00
81_T111_P0.5891.00
90_L109_A0.5831.00
43_T69_A0.5771.00
64_T87_L0.5761.00
47_A54_T0.5701.00
44_Y68_L0.5671.00
53_T56_A0.5651.00
52_G57_G0.5601.00
91_T94_L0.5521.00
66_V89_V0.5481.00
5_V78_A0.5471.00
96_A99_A0.5451.00
25_L29_A0.5431.00
28_V33_A0.5411.00
20_N24_V0.5391.00
27_N51_A0.5361.00
88_L109_A0.5361.00
18_Y54_T0.5351.00
18_Y56_A0.5341.00
5_V25_L0.5341.00
33_A77_V0.5321.00
33_A36_Y0.5211.00
49_R57_G0.5161.00
23_L27_N0.5131.00
20_N47_A0.5131.00
1_A68_L0.5121.00
8_A79_V0.5111.00
17_V28_V0.5101.00
66_V76_V0.5101.00
108_H114_P0.5091.00
102_A106_V0.5091.00
5_V28_V0.5011.00
97_P101_K0.5001.00
12_A82_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vzsA 1 0 51 0.839 Contact Map
4kmqA 1 0.5378 25.7 0.864 Contact Map
2vzpA 1 0.5378 19.9 0.87 Contact Map
4qb6A 1 0.5462 16.4 0.875 Contact Map
3v9fA 1 0.563 12.5 0.882 Contact Map
2w47A 1 0.605 12.1 0.883 Contact Map
3wnoA 2 0.9244 9.3 0.888 Contact Map
2wz8A 1 0.5546 8.3 0.891 Contact Map
1b77A 3 0.6303 8.1 0.891 Contact Map
4f7kA 1 0.8319 7.7 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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