GREMLIN Database
PrcB_C - PrcB C-terminal
PFAM: PF14343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (56)
Sequences: 8065 (6207)
Seq/√Len: 829.4
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_G45_T3.8361.00
39_G42_C2.8381.00
7_L35_E2.3591.00
4_A54_L2.0971.00
7_L37_S2.0181.00
12_T44_V1.9261.00
20_T34_R1.8861.00
9_E50_Y1.8311.00
7_L10_R1.8091.00
9_E48_L1.5971.00
21_S32_R1.4851.00
12_T46_Q1.4151.00
16_S36_T1.4071.00
13_G47_V1.3811.00
19_I22_V1.3761.00
7_L17_I1.3651.00
19_I53_H1.2561.00
20_T32_R1.2341.00
19_I55_V1.2261.00
23_E32_R1.2161.00
18_E36_T1.1721.00
43_M46_Q1.1031.00
18_E34_R1.0981.00
25_T30_V1.0941.00
13_G44_V1.0931.00
6_F52_Y1.0691.00
24_E27_D1.0631.00
12_T49_T1.0581.00
10_R35_E1.0441.00
5_V31_V1.0081.00
5_V53_H0.9681.00
2_V54_L0.9581.00
3_V57_I0.9541.00
5_V33_V0.9431.00
14_G44_V0.9031.00
22_V57_I0.8911.00
43_M47_V0.8721.00
13_G49_T0.8661.00
27_D33_V0.8651.00
23_E30_V0.8521.00
13_G46_Q0.8461.00
5_V17_I0.8461.00
10_R49_T0.8381.00
22_V55_V0.8301.00
11_P48_L0.8211.00
22_V29_L0.8101.00
8_G50_Y0.8021.00
17_I33_V0.7591.00
2_V42_C0.7291.00
25_T28_T0.7241.00
17_I53_H0.7161.00
43_M48_L0.7151.00
4_A52_Y0.6871.00
5_V19_I0.6831.00
6_F50_Y0.6781.00
22_V31_V0.6741.00
18_E53_H0.6561.00
2_V50_Y0.6551.00
53_H56_K0.6531.00
6_F54_L0.6481.00
17_I35_E0.6421.00
15_Y37_S0.6371.00
45_T48_L0.6351.00
7_L33_V0.6301.00
10_R37_S0.6291.00
3_V31_V0.6181.00
52_Y56_K0.6041.00
33_V52_Y0.6031.00
37_S42_C0.5961.00
2_V5_V0.5841.00
24_E28_T0.5831.00
10_R15_Y0.5681.00
13_G43_M0.5641.00
38_P41_G0.5641.00
2_V6_F0.5631.00
2_V56_K0.5611.00
12_T48_L0.5521.00
24_E29_L0.5401.00
38_P44_V0.5351.00
52_Y55_V0.5351.00
6_F53_H0.5281.00
22_V52_Y0.5211.00
29_L35_E0.5081.00
25_T29_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nkhA 2 1 3.9 0.859 Contact Map
1a0pA 1 0.8966 3.4 0.863 Contact Map
2n0yB 1 0.4138 3.4 0.863 Contact Map
1okcA 1 0.569 3 0.867 Contact Map
2lckA 1 0.4828 2.8 0.868 Contact Map
2a3vA 3 0.9138 2.5 0.873 Contact Map
2y35A 1 0.6897 2.4 0.873 Contact Map
3izxD 1 0.8621 2.4 0.874 Contact Map
4h3wA 1 0.9138 2.4 0.874 Contact Map
2ijrA 1 0.9483 2.3 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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