GREMLIN Database
DUF4395 - Domain of unknown function (DUF4395)
PFAM: PF14340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (129)
Sequences: 11666 (7146)
Seq/√Len: 629.1
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_F115_A3.9071.00
118_F123_E3.8501.00
37_A81_L3.6661.00
123_E127_L3.2341.00
51_L55_R3.0701.00
90_L98_L3.0501.00
109_A120_L2.2611.00
91_F99_G2.1271.00
79_I83_F2.0881.00
30_A88_L2.0681.00
52_L56_V2.0531.00
33_A85_L2.0011.00
42_L46_L1.9541.00
40_A78_G1.8581.00
34_L38_I1.6861.00
33_A88_L1.6851.00
11_G114_A1.6701.00
20_A28_L1.6461.00
8_F53_Y1.6381.00
83_F102_L1.6341.00
78_G82_V1.5761.00
79_I124_I1.5591.00
17_L107_L1.4971.00
101_V105_L1.4641.00
84_L106_L1.4631.00
51_L54_R1.4351.00
16_L28_L1.4261.00
69_D72_P1.3971.00
33_A84_L1.3761.00
105_L109_A1.3701.00
90_L102_L1.3651.00
90_L95_A1.3471.00
4_R63_P1.3031.00
14_V111_F1.3011.00
97_T101_V1.2931.00
37_A85_L1.2901.00
111_F116_F1.2841.00
100_W104_G1.2791.00
86_A102_L1.2751.00
87_A103_A1.2681.00
29_L87_A1.2531.00
20_A23_T1.2511.00
12_I49_L1.2491.00
97_T100_W1.2431.00
95_A98_L1.2271.00
93_L96_T1.2251.00
125_Y129_M1.2241.00
121_G126_L1.1991.00
19_V23_T1.1991.00
52_L57_V1.1841.00
1_V6_P1.1761.00
38_I42_L1.1731.00
123_E126_L1.1721.00
88_L92_L1.1591.00
74_R78_G1.1571.00
35_V49_L1.1571.00
20_A29_L1.1381.00
104_G108_V1.1171.00
26_P88_L1.1131.00
20_A103_A1.0871.00
40_A81_L1.0821.00
16_L32_L1.0711.00
14_V110_A1.0551.00
86_A90_L1.0211.00
75_F79_I1.0111.00
89_V93_L0.9921.00
31_L35_V0.9751.00
100_W103_A0.9681.00
14_V107_L0.9641.00
26_P30_A0.9581.00
79_I109_A0.9581.00
87_A102_L0.9501.00
2_D5_A0.9461.00
64_P67_L0.9451.00
35_V39_R0.9301.00
84_L88_L0.9181.00
25_S28_L0.9151.00
37_A41_L0.9151.00
9_N13_V0.9121.00
120_L123_E0.9011.00
58_R63_P0.8931.00
56_V59_P0.8911.00
83_F106_L0.8901.00
82_V86_A0.8891.00
21_L100_W0.8891.00
39_R47_S0.8891.00
124_I127_L0.8771.00
5_A8_F0.8721.00
91_F100_W0.8581.00
27_W31_L0.8551.00
42_L45_R0.8511.00
33_A81_L0.8441.00
5_A54_R0.8371.00
18_L107_L0.8361.00
29_L91_F0.8321.00
33_A37_A0.8291.00
106_L109_A0.8241.00
26_P91_F0.8231.00
5_A58_R0.8221.00
112_L116_F0.8161.00
29_L103_A0.8111.00
81_L85_L0.8071.00
17_L106_L0.7901.00
35_V38_I0.7841.00
101_V104_G0.7801.00
96_T100_W0.7761.00
53_Y58_R0.7741.00
4_R65_P0.7681.00
3_E66_E0.7611.00
76_A80_G0.7561.00
36_F81_L0.7551.00
35_V47_S0.7461.00
38_I46_L0.7391.00
29_L84_L0.7351.00
47_S50_G0.7351.00
83_F105_L0.7271.00
12_I16_L0.7221.00
14_V115_A0.7141.00
21_L24_G0.7021.00
15_V19_V0.6991.00
16_L20_A0.6941.00
17_L103_A0.6931.00
8_F12_I0.6841.00
9_N49_L0.6761.00
44_P70_A0.6741.00
3_E67_L0.6731.00
110_A113_E0.6721.00
113_E116_F0.6691.00
11_G15_V0.6681.00
117_G123_E0.6621.00
88_L91_F0.6611.00
26_P92_L0.6571.00
78_G81_L0.6551.00
91_F96_T0.6451.00
119_C122_C0.6451.00
108_V111_F0.6411.00
112_L118_F0.6391.00
44_P50_G0.6381.00
75_F121_G0.6381.00
3_E6_P0.6351.00
20_A91_F0.6311.00
17_L32_L0.6301.00
18_L22_V0.6251.00
126_L129_M0.6241.00
8_F11_G0.6171.00
32_L36_F0.6151.00
11_G14_V0.6131.00
36_F80_G0.6081.00
30_A92_L0.6041.00
20_A24_G0.6041.00
104_G107_L0.6031.00
109_A118_F0.6031.00
58_R67_L0.6011.00
21_L107_L0.5991.00
13_V17_L0.5991.00
77_Q113_E0.5971.00
9_N53_Y0.5971.00
72_P76_A0.5971.00
10_A13_V0.5961.00
38_I41_L0.5951.00
79_I121_G0.5921.00
87_A106_L0.5891.00
83_F124_I0.5891.00
1_V73_K0.5881.00
80_G83_F0.5791.00
72_P75_F0.5781.00
79_I82_V0.5731.00
45_R51_L0.5721.00
41_L78_G0.5661.00
22_V25_S0.5641.00
112_L120_L0.5611.00
113_E117_G0.5591.00
3_E68_E0.5571.00
4_R8_F0.5561.00
41_L81_L0.5551.00
70_A74_R0.5521.00
12_I15_V0.5491.00
106_L110_A0.5491.00
13_V49_L0.5441.00
45_R48_P0.5410.99
36_F39_R0.5410.99
120_L124_I0.5390.99
14_V18_L0.5370.99
1_V4_R0.5350.99
110_A114_A0.5310.99
25_S31_L0.5290.99
54_R58_R0.5270.99
73_K76_A0.5230.99
29_L88_L0.5230.99
124_I128_L0.5140.99
99_G102_L0.5090.99
60_R63_P0.5040.99
103_A106_L0.5010.99
75_F125_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zzaA 1 0.3231 11 0.909 Contact Map
2mpnA 2 0.4923 10.7 0.909 Contact Map
2b2hA 3 0.9462 8.9 0.912 Contact Map
1u7gA 3 0.9462 4 0.926 Contact Map
4od4A 1 0.8615 3.5 0.928 Contact Map
3ze3A 4 0.7 3.5 0.928 Contact Map
2jlnA 1 0.8154 3.1 0.93 Contact Map
3hd6A 3 0.9462 1.7 0.939 Contact Map
1jmoA 1 0.3615 1.5 0.94 Contact Map
3k3fA 3 0.8462 1.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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