GREMLIN Database
DUF4390 - Domain of unknown function (DUF4390)
PFAM: PF14334 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (157)
Sequences: 7491 (4949)
Seq/√Len: 395.0
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_F103_A3.5661.00
37_Q80_Y3.2951.00
52_R60_E2.7651.00
129_R157_W2.5791.00
49_E127_R2.4631.00
71_L100_A2.3281.00
7_R25_D2.2611.00
114_D117_L2.2151.00
47_E131_R2.1451.00
51_Y61_K2.0001.00
46_L130_A1.9731.00
33_E37_Q1.9521.00
46_L69_Y1.9481.00
96_S99_E1.9111.00
22_A128_V1.9041.00
49_E64_S1.8961.00
17_G111_P1.8791.00
61_K64_S1.8281.00
127_R159_R1.7951.00
79_Q95_A1.7821.00
54_R59_D1.7711.00
82_V103_A1.7261.00
29_S32_L1.7181.00
45_V68_R1.7121.00
23_R106_R1.6931.00
51_Y59_D1.6821.00
92_Q103_A1.6631.00
49_E61_K1.6601.00
51_Y125_Y1.6531.00
45_V66_T1.6291.00
47_E129_R1.6291.00
48_V126_V1.6101.00
51_Y127_R1.6081.00
107_V110_W1.5861.00
41_P70_R1.5251.00
22_A107_V1.5191.00
82_V100_A1.4691.00
36_L42_L1.4681.00
8_S23_R1.4651.00
26_F105_G1.4501.00
52_R122_E1.4441.00
12_E21_S1.4161.00
62_V124_Y1.3941.00
97_L101_L1.3651.00
21_S109_G1.3591.00
119_E122_E1.3521.00
102_R105_G1.3371.00
28_L101_L1.3361.00
30_P33_E1.3151.00
81_R93_S1.3021.00
6_I24_L1.3011.00
24_L130_A1.2991.00
53_P125_Y1.2901.00
32_L42_L1.2771.00
14_S19_L1.2621.00
73_Y78_R1.2461.00
50_L118_L1.2451.00
9_A158_Y1.2421.00
23_R108_R1.2411.00
149_S152_D1.2291.00
125_Y159_R1.1901.00
69_Y84_R1.1841.00
47_E66_T1.1791.00
139_K142_Q1.1681.00
37_Q97_L1.1641.00
121_G124_Y1.1591.00
33_E97_L1.1471.00
59_D125_Y1.1381.00
54_R60_E1.1381.00
49_E157_W1.1271.00
140_P143_L1.1241.00
4_I24_L1.1241.00
144_L147_F1.1071.00
30_P34_E1.1041.00
79_Q93_S1.1031.00
126_V130_A1.1011.00
43_T68_R1.1011.00
46_L107_V1.0921.00
72_S83_S1.0901.00
17_G114_D1.0861.00
6_I9_A1.0821.00
113_A117_L1.0821.00
118_L124_Y1.0821.00
13_L115_L1.0651.00
50_L113_A1.0461.00
6_I128_V1.0431.00
45_V131_R1.0341.00
70_R83_S1.0241.00
118_L121_G1.0231.00
119_E124_Y1.0081.00
145_A148_S0.9961.00
83_S91_Q0.9911.00
72_S81_R0.9841.00
26_F130_A0.9661.00
36_L71_L0.9641.00
127_R157_W0.9591.00
102_R106_R0.9381.00
34_E37_Q0.9311.00
11_L20_L0.9171.00
11_L126_V0.9161.00
137_L140_P0.9121.00
4_I44_F0.9121.00
31_E34_E0.9091.00
56_Y59_D0.9081.00
16_G115_L0.8951.00
19_L109_G0.8861.00
133_D136_Q0.8771.00
27_A105_G0.8671.00
135_S146_F0.8591.00
54_R57_W0.8551.00
68_R85_G0.8451.00
94_F101_L0.8391.00
82_V104_L0.8341.00
42_L132_L0.8321.00
71_L101_L0.8251.00
32_L44_F0.8231.00
33_E101_L0.8191.00
10_E21_S0.8181.00
13_L17_G0.8091.00
48_V110_W0.8011.00
120_P123_R0.7991.00
87_S90_L0.7911.00
6_I130_A0.7831.00
43_T70_R0.7811.00
139_K143_L0.7771.00
74_H81_R0.7681.00
4_I155_S0.7651.00
74_H79_Q0.7641.00
18_L36_L0.7601.00
74_H77_T0.7561.00
85_G88_G0.7511.00
18_L115_L0.7511.00
24_L46_L0.7501.00
84_R87_S0.7501.00
28_L33_E0.7491.00
82_V94_F0.7481.00
5_E25_D0.7481.00
12_E109_G0.7451.00
128_V157_W0.7431.00
96_S100_A0.7261.00
81_R91_Q0.7241.00
77_T81_R0.7161.00
67_R110_W0.7141.00
12_E19_L0.7051.00
134_T145_A0.7041.00
46_L128_V0.7031.00
113_A118_L0.7001.00
71_L104_L0.6951.00
21_S108_R0.6941.00
9_A22_A0.6891.00
143_L153_L0.6860.99
35_A42_L0.6840.99
148_S152_D0.6810.99
133_D151_W0.6810.99
9_A128_V0.6800.99
120_P124_Y0.6740.99
137_L142_Q0.6710.99
44_F100_A0.6710.99
136_Q143_L0.6640.99
99_E102_R0.6640.99
139_K144_L0.6640.99
90_L93_S0.6590.99
10_E13_L0.6580.99
65_L110_W0.6540.99
97_L100_A0.6530.99
98_E102_R0.6480.99
7_R10_E0.6480.99
69_Y104_L0.6420.99
71_L97_L0.6420.99
44_F104_L0.6410.99
11_L112_V0.6390.99
134_T152_D0.6350.99
144_L152_D0.6340.99
74_H110_W0.6340.99
50_L124_Y0.6330.99
9_A126_V0.6300.99
104_L130_A0.6300.99
44_F105_G0.6300.99
34_E38_S0.6290.99
94_F99_E0.6290.99
32_L35_A0.6250.99
138_P151_W0.6240.99
36_L80_Y0.6230.99
28_L32_L0.6180.99
76_L140_P0.6160.99
136_Q146_F0.6130.99
20_L48_V0.6110.99
69_Y86_G0.6080.99
129_R156_D0.6060.99
63_A117_L0.6050.99
20_L126_V0.6030.99
14_S115_L0.6010.99
31_E150_D0.5980.99
13_L18_L0.5970.99
71_L82_V0.5890.98
48_V128_V0.5860.98
48_V112_V0.5800.98
136_Q142_Q0.5800.98
14_S109_G0.5780.98
39_G76_L0.5740.98
135_S145_A0.5740.98
18_L113_A0.5740.98
101_L105_G0.5720.98
13_L21_S0.5680.98
76_L79_Q0.5650.98
66_T133_D0.5650.98
41_P72_S0.5640.98
92_Q108_R0.5630.98
130_A144_L0.5630.98
148_S155_S0.5610.98
141_L153_L0.5600.98
114_D118_L0.5580.98
35_A40_V0.5510.98
55_W59_D0.5490.98
14_S17_G0.5470.97
147_F150_D0.5470.97
62_V77_T0.5450.97
45_V133_D0.5440.97
140_P145_A0.5410.97
134_T146_F0.5400.97
40_V142_Q0.5340.97
78_R95_A0.5310.97
52_R57_W0.5270.97
135_S144_L0.5150.96
101_L104_L0.5140.96
8_S21_S0.5120.96
70_R81_R0.5120.96
98_E106_R0.5120.96
54_R58_F0.5110.96
43_T104_L0.5110.96
65_L114_D0.5090.96
47_E64_S0.5080.96
145_A149_S0.5070.96
6_I22_A0.5030.96
67_R84_R0.5020.96
144_L148_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xcmC 1 0.3727 4.1 0.935 Contact Map
1sh8A 2 0.4534 4.1 0.935 Contact Map
4qqdA 1 0.6149 3.6 0.937 Contact Map
2llgA 1 0.4348 3.5 0.937 Contact Map
4pbdA 1 0.5839 3.4 0.937 Contact Map
3eudA 1 0.5963 3.3 0.938 Contact Map
4gioA 1 0.4658 3.3 0.938 Contact Map
2ffgA 1 0.4783 2.9 0.94 Contact Map
1y8xB 1 0.3665 2.8 0.94 Contact Map
4alzA 1 0.3354 2.7 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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