GREMLIN Database
DUF4389 - Domain of unknown function (DUF4389)
PFAM: PF14333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (71)
Sequences: 28187 (14623)
Seq/√Len: 1735.4
META: 0.976

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A42_Y3.6221.00
36_I42_Y2.2831.00
11_A64_L2.2561.00
31_I46_L2.1791.00
25_A50_V2.1451.00
44_R48_D2.1261.00
28_V46_L2.1221.00
22_G57_S2.0461.00
14_H56_W1.9031.00
32_A43_P1.8601.00
30_I34_F1.8331.00
24_A49_F1.8301.00
19_A23_I1.6741.00
57_S61_Y1.6551.00
11_A15_L1.6081.00
28_V50_V1.6021.00
21_L53_V1.5441.00
25_A53_V1.5121.00
42_Y47_F1.4691.00
35_A43_P1.4591.00
58_A62_A1.4341.00
47_F51_V1.2911.00
27_V31_I1.2291.00
19_A22_G1.1901.00
29_A50_V1.1751.00
42_Y50_V1.1541.00
6_F10_L1.1421.00
22_G53_V1.1241.00
14_H18_L1.1111.00
18_L57_S1.0741.00
8_W33_W1.0621.00
58_A61_Y1.0601.00
18_L22_G1.0511.00
14_H60_V1.0101.00
61_Y65_L1.0041.00
17_V56_W0.9941.00
51_V55_R0.9781.00
17_V20_F0.9711.00
71_Y74_F0.9691.00
20_F24_A0.9571.00
62_A67_L0.9401.00
50_V54_L0.9361.00
54_L58_A0.9221.00
22_G26_F0.9211.00
11_A60_V0.9011.00
36_I39_T0.8921.00
7_R69_D0.8821.00
15_L60_V0.8481.00
29_A33_W0.8441.00
44_R47_F0.8211.00
16_I20_F0.8161.00
58_A67_L0.7961.00
34_F38_F0.7951.00
7_R66_L0.7951.00
5_L8_W0.7871.00
21_L52_G0.7801.00
21_L56_W0.7731.00
26_F30_I0.7661.00
49_F53_V0.7651.00
56_W60_V0.7581.00
4_V66_L0.7381.00
53_V57_S0.7381.00
18_L60_V0.7311.00
62_A68_T0.7281.00
45_G48_D0.7241.00
35_A39_T0.7151.00
8_W64_L0.7101.00
48_D52_G0.7081.00
52_G56_W0.7051.00
62_A65_L0.6961.00
19_A26_F0.6911.00
54_L57_S0.6851.00
31_I35_A0.6801.00
33_W66_L0.6751.00
14_H71_Y0.6751.00
14_H63_Y0.6711.00
41_R44_R0.6641.00
14_H17_V0.6421.00
63_Y66_L0.6381.00
23_I27_V0.6371.00
32_A46_L0.6331.00
36_I47_F0.6311.00
24_A27_V0.6301.00
50_V53_V0.6271.00
51_V54_L0.6181.00
63_Y68_T0.6141.00
20_F23_I0.6041.00
62_A66_L0.6041.00
51_V62_A0.5991.00
34_F37_L0.5951.00
56_W73_P0.5911.00
25_A29_A0.5751.00
59_R68_T0.5671.00
48_D51_V0.5541.00
10_L14_H0.5481.00
49_F52_G0.5451.00
55_R59_R0.5391.00
39_T45_G0.5351.00
18_L53_V0.5341.00
21_L49_F0.5181.00
14_H73_P0.5121.00
32_A36_I0.5111.00
15_L19_A0.5111.00
33_W40_G0.5061.00
10_L63_Y0.5061.00
6_F9_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k1tA 2 0.5921 2.4 0.896 Contact Map
3rvyA 3 0.9211 2 0.899 Contact Map
2kogA 1 0.3816 1.5 0.906 Contact Map
3fymA 1 0 1.5 0.906 Contact Map
3j08A 2 1 1.4 0.908 Contact Map
1j7mA 1 0.2368 1.3 0.91 Contact Map
3wvoA 2 0.8684 1.3 0.911 Contact Map
2r2nA 2 0.6447 1.2 0.913 Contact Map
3dl8C 1 0.4342 1.2 0.913 Contact Map
4bgnA 3 0.8553 1.1 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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