GREMLIN Database
DUF4388 - Domain of unknown function (DUF4388)
PFAM: PF14332 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (91)
Sequences: 34468 (22623)
Seq/√Len: 2371.5
META: 0.973

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_A79_T2.6131.00
24_V35_R2.4861.00
34_G54_L2.3791.00
45_H74_T2.3221.00
23_G64_F2.3171.00
29_S57_W2.2101.00
39_R44_V2.0651.00
26_T65_E1.9281.00
11_D19_S1.8591.00
55_L86_G1.8461.00
24_V37_Y1.7971.00
26_T35_R1.7201.00
52_Y89_R1.7181.00
78_S81_A1.6361.00
73_R76_T1.6011.00
29_S32_G1.5701.00
37_Y45_H1.5621.00
2_G62_F1.5561.00
17_A80_E1.5531.00
84_L91_D1.5501.00
46_A50_A1.4791.00
28_T33_E1.4771.00
85_E88_R1.4741.00
16_L21_K1.4571.00
7_F15_L1.4461.00
17_A42_R1.3611.00
26_T33_E1.3591.00
22_T39_R1.3401.00
22_T41_G1.2831.00
24_V67_G1.2721.00
36_I51_L1.2691.00
13_L79_T1.2681.00
16_L38_F1.2561.00
3_S6_D1.2291.00
3_S61_T1.2201.00
5_S59_E1.2121.00
14_Q18_L1.2091.00
34_G50_A1.2081.00
56_S93_W1.1761.00
4_L9_L1.1751.00
36_I43_I1.1611.00
42_R78_S1.1351.00
25_L64_F1.1341.00
26_T63_E1.1281.00
52_Y86_G1.1271.00
9_L27_V1.1181.00
84_L87_A1.1161.00
20_R40_D1.0991.00
28_T61_T1.0901.00
8_S11_D1.0881.00
51_L82_L1.0591.00
34_G53_E1.0491.00
39_R73_R1.0251.00
4_L60_G0.9881.00
21_K64_F0.9531.00
42_R79_T0.9471.00
36_I54_L0.9361.00
43_I79_T0.9301.00
53_E56_S0.9161.00
58_T90_L0.9001.00
15_L19_S0.8981.00
24_V65_E0.8981.00
65_E68_E0.8751.00
28_T63_E0.8581.00
21_K66_P0.8501.00
88_R92_E0.8471.00
56_S90_L0.8371.00
81_A85_E0.8181.00
35_R48_Q0.8171.00
49_E89_R0.8161.00
67_G70_P0.8131.00
14_Q80_E0.8071.00
29_S59_E0.8061.00
49_E52_Y0.7981.00
13_L51_L0.7901.00
24_V68_E0.7811.00
22_T40_D0.7811.00
34_G46_A0.7751.00
17_A78_S0.7751.00
27_V54_L0.7721.00
45_H71_P0.7711.00
34_G57_W0.7631.00
77_L82_L0.7631.00
87_A91_D0.7581.00
13_L36_I0.7551.00
14_Q84_L0.7411.00
30_G59_E0.7371.00
77_L81_A0.7221.00
52_Y85_E0.7191.00
12_L62_F0.7081.00
6_D21_K0.7061.00
85_E89_R0.7061.00
51_L86_G0.6991.00
81_A84_L0.6761.00
39_R69_P0.6591.00
86_G90_L0.6581.00
42_R73_R0.6561.00
16_L23_G0.6521.00
53_E57_W0.6421.00
36_I46_A0.6261.00
3_S59_E0.6251.00
44_V73_R0.6211.00
57_W60_G0.6161.00
23_G67_G0.6151.00
32_G57_W0.6121.00
84_L88_R0.6111.00
50_A53_E0.6061.00
49_E53_E0.6011.00
6_D66_P0.5921.00
71_P74_T0.5881.00
10_P87_A0.5861.00
34_G45_H0.5701.00
9_L54_L0.5671.00
77_L85_E0.5651.00
89_R93_W0.5651.00
16_L64_F0.5631.00
15_L62_F0.5571.00
4_L27_V0.5571.00
23_G38_F0.5561.00
12_L16_L0.5531.00
11_D18_L0.5511.00
25_L38_F0.5481.00
15_L18_L0.5441.00
12_L23_G0.5411.00
42_R80_E0.5401.00
9_L13_L0.5301.00
11_D14_Q0.5251.00
7_F21_K0.5241.00
12_L64_F0.5191.00
88_R91_D0.5181.00
86_G89_R0.5151.00
10_P14_Q0.5131.00
37_Y71_P0.5071.00
13_L38_F0.5071.00
81_A88_R0.5061.00
11_D15_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l48A 2 0.6596 18.1 0.857 Contact Map
2ayiA 2 0.9681 16.9 0.859 Contact Map
1zjcA 2 0.9681 15.3 0.861 Contact Map
4icsA 2 0.9681 15.3 0.861 Contact Map
3d72A 2 0.9362 10.4 0.872 Contact Map
4wujA 3 0.9681 9.8 0.873 Contact Map
4nwbA 2 0.8085 7.7 0.879 Contact Map
4hoiA 2 0.6915 7.3 0.88 Contact Map
1n9lA 2 0.6809 6.4 0.883 Contact Map
3t50A 2 0.7128 6.3 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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