GREMLIN Database
DUF4387 - Domain of unknown function (DUF4387)
PFAM: PF14330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (96)
Sequences: 4695 (2919)
Seq/√Len: 297.9
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R31_E4.1941.00
26_D29_T3.8901.00
27_R65_L3.4161.00
42_E52_P3.0581.00
31_E35_A2.4841.00
34_K62_D2.4821.00
30_Y62_D2.4731.00
34_K60_E2.3201.00
24_F33_V2.1271.00
77_S85_V1.9971.00
17_E70_T1.9891.00
25_D29_T1.9861.00
60_E67_I1.9531.00
43_L46_R1.8621.00
20_F71_I1.7051.00
5_A22_I1.6791.00
56_V72_P1.6691.00
42_E46_R1.6201.00
92_A95_L1.5451.00
32_R36_S1.4911.00
37_G60_E1.4811.00
58_F69_I1.4681.00
45_A52_P1.4661.00
16_F76_P1.4481.00
30_Y60_E1.4441.00
6_K25_D1.4411.00
61_F64_A1.4341.00
41_R52_P1.4261.00
4_L29_T1.3511.00
73_R82_D1.3491.00
82_D85_V1.3481.00
31_E62_D1.3471.00
31_E34_K1.3221.00
75_V81_G1.2241.00
27_R62_D1.2101.00
45_A55_I1.2061.00
76_P79_S1.1991.00
88_A91_H1.1351.00
23_I66_A1.0571.00
43_L97_L1.0561.00
55_I72_P1.0491.00
39_L58_F1.0461.00
20_F94_L1.0431.00
18_L87_G1.0371.00
18_L71_I1.0241.00
50_V71_I1.0231.00
43_L47_L1.0181.00
51_P55_I1.0041.00
75_V79_S0.9861.00
44_I69_I0.9841.00
4_L33_V0.9611.00
40_T43_L0.9581.00
86_Y91_H0.9501.00
75_V82_D0.8921.00
29_T32_R0.8371.00
30_Y34_K0.8351.00
41_R58_F0.8331.00
23_I64_A0.8301.00
74_P83_R0.8171.00
33_V36_S0.8041.00
79_S82_D0.8011.00
45_A72_P0.7940.99
20_F69_I0.7870.99
4_L32_R0.7850.99
83_R88_A0.7820.99
17_E56_V0.7730.99
5_A8_I0.7700.99
28_E31_E0.7620.99
58_F67_I0.7620.99
11_K15_P0.7610.99
17_E72_P0.7610.99
28_E32_R0.7590.99
19_T70_T0.7590.99
48_Y93_P0.7580.99
40_T58_F0.7530.99
34_K67_I0.7500.99
57_K72_P0.7390.99
1_L8_I0.7390.99
20_F44_I0.7350.99
91_H95_L0.7350.99
50_V55_I0.7250.99
20_F48_Y0.7220.99
7_V88_A0.7140.99
18_L74_P0.6890.99
78_G82_D0.6860.99
40_T46_R0.6830.98
77_S86_Y0.6730.98
9_R23_I0.6660.98
73_R78_G0.6630.98
44_I48_Y0.6630.98
41_R45_A0.6530.98
38_V43_L0.6500.98
25_D65_L0.6440.98
18_L73_R0.6380.98
5_A33_V0.6370.98
18_L90_Q0.6320.97
59_F70_T0.6250.97
39_L44_I0.6200.97
61_F70_T0.6200.97
17_E64_A0.6180.97
22_I69_I0.6110.97
7_V23_I0.6050.97
38_V97_L0.6010.97
7_V91_H0.5920.96
17_E76_P0.5900.96
3_D6_K0.5900.96
41_R56_V0.5890.96
88_A92_A0.5860.96
48_Y71_I0.5820.96
59_F86_Y0.5810.96
35_A60_E0.5760.96
86_Y92_A0.5750.96
88_A95_L0.5740.96
77_S80_P0.5720.96
5_A25_D0.5690.95
14_G73_R0.5690.95
7_V18_L0.5640.95
10_S20_F0.5580.95
42_E53_E0.5570.95
76_P82_D0.5550.95
37_G40_T0.5530.95
41_R55_I0.5510.95
85_V91_H0.5510.95
22_I67_I0.5510.95
92_A96_D0.5460.94
2_G96_D0.5410.94
78_G85_V0.5400.94
25_D64_A0.5360.94
29_T65_L0.5300.93
1_L4_L0.5280.93
39_L43_L0.5280.93
11_K86_Y0.5230.93
11_K16_F0.5220.93
48_Y91_H0.5220.93
41_R60_E0.5220.93
78_G83_R0.5200.93
33_V67_I0.5170.92
29_T38_V0.5160.92
45_A51_P0.5120.92
2_G8_I0.5100.92
33_V37_G0.5080.92
5_A24_F0.5040.91
25_D33_V0.5040.91
13_A17_E0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uowA 2 0.3367 12.4 0.933 Contact Map
3tqiA 3 0.3265 8.3 0.938 Contact Map
4ecqA 1 0.7755 8.1 0.938 Contact Map
2dplA 2 0.3367 7.7 0.939 Contact Map
4j2nA 4 0.5102 7.4 0.94 Contact Map
2ywbA 4 0.3367 7.2 0.94 Contact Map
1gpmA 3 0.3367 6 0.942 Contact Map
5a0dA 1 0.3776 5.2 0.944 Contact Map
3hhwA 3 0.6531 4.7 0.945 Contact Map
1dgwA 3 0.7143 4.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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