GREMLIN Database
DUF4385 - Domain of unknown function (DUF4385)
PFAM: PF14328 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (145)
Sequences: 1197 (689)
Seq/√Len: 57.2
META: 0.715

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_L72_M4.4411.00
31_E35_S3.6051.00
40_H59_M3.5431.00
124_K128_D3.4291.00
53_S126_K3.1481.00
60_F130_A2.9561.00
37_I56_I2.7411.00
57_Y61_L2.7351.00
64_L133_D2.5751.00
45_T48_I2.5151.00
46_P119_S2.3801.00
87_R117_A2.2871.00
86_A119_S2.1941.00
37_I59_M2.1861.00
72_M133_D2.1761.00
6_Y11_F2.0531.00
40_H55_K2.0381.00
126_K129_K1.9941.00
128_D132_E1.9911.00
79_L130_A1.9791.00
10_D13_E1.8370.99
83_F127_W1.8080.99
55_K59_M1.8020.99
117_A120_A1.7960.99
118_E121_R1.7900.99
57_Y126_K1.7200.99
128_D131_R1.6570.99
46_P118_E1.6450.99
50_R54_E1.6430.99
44_K48_I1.6280.99
5_D8_N1.6060.99
76_R80_Q1.6020.99
24_E76_R1.5960.99
46_P115_E1.5830.98
6_Y9_I1.4800.98
31_E34_K1.4500.97
93_K116_K1.4460.97
110_D113_D1.4340.97
46_P122_I1.4280.97
135_K138_R1.4040.97
67_G135_K1.3820.96
24_E80_Q1.3810.96
119_S122_I1.3770.96
107_Q110_D1.3770.96
56_I59_M1.3270.95
107_Q111_E1.3030.95
55_K58_E1.2790.94
37_I40_H1.2670.94
92_H112_E1.2630.94
12_R36_E1.2440.93
138_R142_E1.2300.93
140_K144_R1.2150.93
135_K139_M1.1820.92
1_D5_D1.1560.91
11_F30_V1.1550.91
54_E126_K1.1520.90
93_K114_P1.1160.89
4_L17_L1.1160.89
131_R143_H1.1090.89
131_R137_L1.0920.88
38_L78_F1.0820.87
53_S129_K1.0720.87
132_E137_L1.0660.87
142_E145_E1.0570.86
62_D66_Q1.0520.86
99_D103_G1.0420.85
93_K111_E1.0290.85
4_L19_R1.0270.85
10_D15_P1.0040.83
12_R15_P1.0040.83
94_G111_E0.9970.83
105_K108_E0.9950.83
56_I79_L0.9680.81
57_Y129_K0.9650.81
52_S123_F0.9610.80
124_K127_W0.9590.80
104_V108_E0.9590.80
87_R120_A0.9570.80
60_F72_M0.9390.79
45_T119_S0.8750.74
50_R125_E0.8550.72
139_M143_H0.8490.72
43_F52_S0.8390.71
137_L143_H0.8360.70
56_I75_A0.8340.70
13_E17_L0.8260.69
8_N30_V0.8230.69
1_D4_L0.8200.69
94_G112_E0.8200.69
104_V107_Q0.8150.68
38_L80_Q0.8110.68
42_R48_I0.8010.67
104_V110_D0.7980.67
131_R140_K0.7970.67
61_L126_K0.7900.66
96_R103_G0.7860.66
141_K144_R0.7850.65
55_K62_D0.7830.65
141_K145_E0.7790.65
137_L140_K0.7770.65
121_R124_K0.7770.65
4_L29_L0.7710.64
30_V74_M0.7690.64
127_W140_K0.7580.63
76_R98_Y0.7570.63
121_R125_E0.7480.62
47_E115_E0.7470.62
20_I23_G0.7460.61
36_E63_Y0.7370.61
19_R24_E0.7370.61
72_M130_A0.7340.60
67_G139_M0.7310.60
43_F123_F0.7310.60
100_K103_G0.7270.60
87_R91_N0.7180.59
125_E129_K0.7180.59
92_H110_D0.7170.58
50_R65_E0.7110.58
5_D30_V0.7090.58
140_K143_H0.7080.57
131_R144_R0.7070.57
48_I51_E0.6990.57
116_K120_A0.6980.56
107_Q113_D0.6980.56
21_G25_Q0.6950.56
11_F29_L0.6940.56
134_E138_R0.6920.56
15_P70_V0.6900.56
88_R95_G0.6880.55
59_M62_D0.6820.55
4_L9_I0.6780.54
60_F75_A0.6760.54
117_A121_R0.6750.54
61_L129_K0.6600.52
108_E111_E0.6540.52
103_G106_P0.6540.52
115_E118_E0.6530.52
133_D139_M0.6510.51
111_E114_P0.6450.51
83_F110_D0.6400.50
47_E54_E0.6330.49
6_Y29_L0.6330.49
108_E113_D0.6290.49
34_K80_Q0.6240.48
99_D106_P0.6230.48
62_D65_E0.6230.48
34_K38_L0.6190.48
20_I131_R0.6160.47
57_Y130_A0.6150.47
6_Y30_V0.6120.47
94_G108_E0.6110.47
66_Q118_E0.6100.47
53_S125_E0.6070.46
42_R52_S0.6050.46
24_E98_Y0.6040.46
110_D114_P0.6030.46
54_E125_E0.6010.46
127_W131_R0.5950.45
47_E129_K0.5930.45
103_G108_E0.5920.45
50_R118_E0.5870.44
15_P36_E0.5860.44
80_Q83_F0.5860.44
114_P118_E0.5860.44
4_L8_N0.5740.43
35_S39_P0.5730.43
51_E62_D0.5730.43
22_R124_K0.5720.43
100_K104_V0.5710.43
57_Y67_G0.5700.42
10_D142_E0.5680.42
80_Q127_W0.5660.42
48_I53_S0.5620.42
92_H106_P0.5610.41
25_Q44_K0.5610.41
45_T118_E0.5600.41
43_F46_P0.5550.41
109_P112_E0.5550.41
64_L135_K0.5530.41
54_E58_E0.5510.40
96_R100_K0.5500.40
124_K132_E0.5440.40
43_F119_S0.5430.40
92_H108_E0.5410.39
96_R104_V0.5390.39
72_M76_R0.5390.39
101_D104_V0.5390.39
138_R141_K0.5370.39
134_E137_L0.5340.39
75_A130_A0.5340.39
61_L133_D0.5320.38
62_D121_R0.5310.38
36_E39_P0.5310.38
65_E106_P0.5270.38
119_S123_F0.5270.38
123_F127_W0.5250.38
108_E112_E0.5250.38
14_H17_L0.5230.38
53_S61_L0.5230.38
86_A94_G0.5160.37
92_H107_Q0.5160.37
78_F96_R0.5160.37
67_G142_E0.5160.37
3_S7_K0.5160.37
64_L130_A0.5150.37
39_P63_Y0.5150.37
134_E139_M0.5110.36
105_K113_D0.5100.36
93_K112_E0.5100.36
47_E142_E0.5100.36
28_L91_N0.5090.36
61_L65_E0.5070.36
7_K11_F0.5050.36
104_V113_D0.5030.35
79_L134_E0.5030.35
106_P110_D0.5020.35
115_E122_I0.5020.35
9_I17_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h41A 3 0.4041 11.1 0.961 Contact Map
1gwmA 1 0.3151 4.3 0.968 Contact Map
3r3jA 5 0.4315 4.3 0.968 Contact Map
2b7eA 1 0.2192 4.2 0.968 Contact Map
4x86A 1 0.2329 3.8 0.969 Contact Map
3v76A 2 0.3356 3 0.97 Contact Map
2dkhA 2 0.3836 2.7 0.971 Contact Map
1uzcA 1 0.2877 2.4 0.972 Contact Map
1i60A 1 0.4247 2.1 0.973 Contact Map
2basA 2 0.4863 2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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