GREMLIN Database
DUF4384 - Domain of unknown function (DUF4384)
PFAM: PF14326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (79)
Sequences: 22206 (17205)
Seq/√Len: 1935.7
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_G77_A3.3911.00
22_V75_A2.7931.00
4_S68_P2.7371.00
14_S18_G2.4301.00
17_D46_R2.4031.00
11_R50_T2.3851.00
13_R50_T2.3411.00
11_R52_E2.3031.00
7_R61_W2.2971.00
3_R6_D2.2891.00
9_R52_E2.1521.00
23_F33_L2.0151.00
16_R79_R1.9501.00
17_D47_A1.9261.00
17_D44_R1.7381.00
7_R63_R1.7051.00
46_R49_Q1.6741.00
25_I31_V1.6221.00
24_N71_E1.5861.00
26_D30_E1.5521.00
26_D32_T1.3981.00
4_S67_P1.3611.00
23_F76_I1.3111.00
24_N32_T1.2831.00
19_Y43_N1.2561.00
21_Y43_N1.2451.00
19_Y44_R1.2291.00
12_V20_L1.2261.00
46_R51_Y1.2211.00
4_S66_G1.2121.00
35_F43_N1.1841.00
21_Y78_S1.1731.00
25_I74_L1.1711.00
55_G58_D1.1631.00
10_L73_L1.1331.00
12_V51_Y1.1151.00
35_F53_I1.0651.00
25_I72_T1.0591.00
20_L75_A1.0531.00
21_Y33_L1.0401.00
23_F31_V1.0271.00
5_G63_R0.9541.00
14_S45_V0.9501.00
57_G60_F0.9391.00
13_R48_G0.9231.00
2_Y6_D0.8911.00
4_S65_D0.8851.00
37_N41_G0.8761.00
34_L73_L0.8731.00
2_Y64_V0.8501.00
27_S71_E0.8161.00
23_F74_L0.8111.00
64_V71_E0.8011.00
27_S69_G0.7931.00
27_S70_T0.7931.00
60_F63_R0.7891.00
41_G44_R0.7741.00
39_F60_F0.7641.00
9_R61_W0.7601.00
20_L77_A0.7301.00
37_N40_D0.7041.00
8_L64_V0.6991.00
15_N18_G0.6981.00
45_V51_Y0.6951.00
55_G59_G0.6871.00
34_L62_F0.6831.00
40_D55_G0.6781.00
60_F64_V0.6631.00
45_V48_G0.6601.00
21_Y76_I0.6601.00
21_Y25_I0.6581.00
20_L45_V0.6581.00
24_N34_L0.6461.00
42_D46_R0.6451.00
52_E55_G0.6301.00
27_S68_P0.6301.00
40_D58_D0.6241.00
31_V74_L0.6231.00
19_Y78_S0.6091.00
8_L24_N0.6081.00
14_S77_A0.6061.00
52_E56_P0.5911.00
69_G75_A0.5861.00
18_G45_V0.5811.00
22_V53_I0.5781.00
58_D61_W0.5761.00
54_P62_F0.5761.00
16_R47_A0.5711.00
28_D67_P0.5691.00
10_L34_L0.5681.00
12_V45_V0.5661.00
20_L35_F0.5651.00
74_L78_S0.5631.00
42_D45_V0.5581.00
26_D71_E0.5521.00
38_R41_G0.5511.00
18_G79_R0.5471.00
40_D60_F0.5471.00
15_N47_A0.5431.00
14_S20_L0.5401.00
10_L24_N0.5391.00
23_F54_P0.5351.00
28_D31_V0.5331.00
27_S67_P0.5311.00
35_F45_V0.5281.00
66_G69_G0.5241.00
39_F43_N0.5231.00
37_N60_F0.5211.00
21_Y24_N0.5171.00
74_L79_R0.5151.00
17_D48_G0.5141.00
2_Y5_G0.5131.00
57_G61_W0.5101.00
10_L62_F0.5091.00
56_P59_G0.5041.00
11_R14_S0.5021.00
41_G45_V0.5001.00
9_R56_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eweA 1 0.8765 26.6 0.819 Contact Map
2p17A 1 0.8395 21.5 0.827 Contact Map
3qacA 3 0.9506 19.1 0.831 Contact Map
2vqaA 3 0.963 16.9 0.836 Contact Map
1tq5A 1 0.8025 16.5 0.836 Contact Map
2e9qA 6 0.9506 16.2 0.836 Contact Map
4f7kA 1 0.8889 16 0.837 Contact Map
3kscA 4 0.9506 15.9 0.837 Contact Map
1j58A 5 0.963 14.9 0.839 Contact Map
3hrzA 1 0.9012 14.6 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.