GREMLIN Database
DUF4383 - Domain of unknown function (DUF4383)
PFAM: PF14325 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (118)
Sequences: 7257 (4793)
Seq/√Len: 441.2
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_G75_Y4.5361.00
84_L115_G3.5211.00
58_F83_Y2.9091.00
87_A112_L2.8511.00
11_F114_L2.7051.00
68_S71_A2.4721.00
45_F110_L1.9201.00
73_R77_L1.9031.00
77_L123_L1.8961.00
5_L66_A1.8911.00
3_A76_L1.8371.00
87_A115_G1.7351.00
40_K46_Q1.7311.00
89_L93_V1.7281.00
87_A91_L1.6961.00
8_G63_L1.6751.00
58_F79_F1.6391.00
16_I20_I1.6301.00
27_Y30_L1.5501.00
106_A109_W1.5401.00
60_V64_A1.5201.00
77_L122_G1.5121.00
19_F52_N1.4801.00
80_G115_G1.4601.00
32_F35_H1.4131.00
51_H107_D1.4111.00
12_L59_G1.3811.00
10_V14_V1.3591.00
74_T78_G1.3521.00
105_G109_W1.3441.00
80_G119_L1.3421.00
93_V96_G1.3401.00
65_A71_A1.3151.00
3_A118_M1.3081.00
5_L63_L1.3011.00
62_G118_M1.2961.00
119_L123_L1.2901.00
55_H111_H1.2761.00
11_F58_F1.2651.00
3_A121_L1.2601.00
58_F114_L1.2431.00
2_T6_V1.2241.00
91_L108_N1.2181.00
12_L63_L1.2171.00
76_L118_M1.2151.00
38_G46_Q1.2091.00
15_G56_L1.2021.00
103_L108_N1.1651.00
28_D31_S1.1571.00
70_A74_T1.1521.00
114_L118_M1.1421.00
109_W113_V1.1351.00
61_A65_A1.1131.00
81_V85_L1.1071.00
91_L112_L1.0531.00
87_A109_W1.0471.00
54_V86_L1.0421.00
5_L9_A1.0381.00
49_G53_L1.0381.00
104_N107_D1.0081.00
105_G108_N0.9981.00
93_V97_S0.9951.00
71_A74_T0.9881.00
8_G59_G0.9691.00
31_S35_H0.9591.00
2_T5_L0.9571.00
62_G65_A0.9491.00
46_Q102_P0.9411.00
31_S36_T0.9411.00
69_A73_R0.9401.00
31_S34_G0.9381.00
12_L56_L0.9241.00
46_Q104_N0.9181.00
18_G52_N0.9171.00
27_Y31_S0.9131.00
107_D111_H0.8971.00
15_G59_G0.8911.00
67_R71_A0.8881.00
41_L47_V0.8831.00
115_G119_L0.8671.00
33_A36_T0.8671.00
116_L120_A0.8661.00
28_D33_A0.8641.00
65_A75_Y0.8631.00
65_A68_S0.8581.00
50_L54_V0.8541.00
51_H55_H0.8341.00
78_G82_V0.8301.00
74_T77_L0.8251.00
17_L41_L0.8191.00
90_G108_N0.8021.00
70_A73_R0.8021.00
9_A13_L0.8011.00
1_R69_A0.7901.00
55_H83_Y0.7861.00
4_A76_L0.7761.00
6_V10_V0.7741.00
58_F82_V0.7651.00
7_F76_L0.7571.00
48_N102_P0.7561.00
67_R70_A0.7501.00
30_L34_G0.7491.00
120_A123_L0.7411.00
51_H83_Y0.7371.00
30_L36_T0.7351.00
95_G108_N0.7281.00
27_Y32_F0.7271.00
19_F49_G0.7221.00
52_N55_H0.7221.00
28_D32_F0.7211.00
44_L106_A0.7181.00
29_G32_F0.7171.00
107_D110_L0.7131.00
38_G41_L0.7091.00
2_T69_A0.7051.00
79_F83_Y0.7021.00
64_A67_R0.7021.00
11_F83_Y0.7011.00
113_V117_V0.7001.00
75_Y79_F0.6971.00
65_A72_A0.6961.00
51_H111_H0.6921.00
85_L89_L0.6881.00
7_F118_M0.6881.00
61_A82_V0.6861.00
106_A110_L0.6851.00
40_K104_N0.6821.00
65_A78_G0.6811.00
47_V55_H0.6791.00
30_L33_A0.6761.00
14_V55_H0.6701.00
86_L90_G0.6691.00
14_V83_Y0.6691.00
93_V99_G0.6631.00
89_L95_G0.6631.00
30_L35_H0.6611.00
78_G122_G0.6541.00
8_G62_G0.6480.99
2_T66_A0.6420.99
32_F36_T0.6410.99
61_A75_Y0.6310.99
51_H54_V0.6200.99
53_L57_L0.6170.99
46_Q49_G0.6150.99
29_G38_G0.6130.99
30_L39_G0.6090.99
48_N98_L0.6080.99
47_V52_N0.6080.99
76_L121_L0.6050.99
82_V85_L0.6040.99
91_L105_G0.6020.99
4_A62_G0.5880.99
3_A7_F0.5860.99
31_S37_S0.5760.99
28_D36_T0.5760.99
118_M121_L0.5730.99
38_G104_N0.5710.99
79_F118_M0.5630.99
7_F11_F0.5610.99
28_D38_G0.5580.98
13_L17_L0.5580.98
37_S40_K0.5550.98
102_P105_G0.5460.98
17_L20_I0.5450.98
50_L101_L0.5410.98
14_V51_H0.5390.98
12_L60_V0.5390.98
27_Y33_A0.5370.98
97_S103_L0.5330.98
45_F107_D0.5320.98
29_G40_K0.5280.98
24_T52_N0.5220.98
113_V120_A0.5150.97
32_F38_G0.5070.97
76_L80_G0.5070.97
94_G97_S0.5010.97
7_F117_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.8952 6.1 0.9 Contact Map
2ww9B 1 0.2661 3 0.914 Contact Map
1rh5B 1 0.2661 2.9 0.915 Contact Map
3mp7B 1 0.25 2.2 0.92 Contact Map
4w252 1 0.2823 1.8 0.924 Contact Map
2mpnA 2 0.2823 1.5 0.927 Contact Map
4p79A 1 0.5565 1.4 0.928 Contact Map
1qleC 1 0.7581 1.3 0.93 Contact Map
1m56C 2 0.7581 1.3 0.93 Contact Map
1fftC 1 0.7823 1.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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