GREMLIN Database
DUF4382 - Domain of unknown function (DUF4382)
PFAM: PF14321 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (130)
Sequences: 11557 (8476)
Seq/√Len: 743.4
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_W43_L3.5411.00
55_D58_D3.4901.00
18_S55_D2.8351.00
25_S83_V2.7871.00
29_H40_W2.5451.00
25_S42_T2.4331.00
24_T85_G2.3651.00
76_T105_D2.2581.00
5_S115_D2.2221.00
7_S115_D2.2081.00
22_T53_T2.1491.00
89_T135_I2.1041.00
22_T85_G2.0711.00
27_E83_V2.0631.00
29_H78_T2.0121.00
90_V93_G1.9251.00
127_V137_K1.9041.00
10_D119_D1.8441.00
109_A112_G1.8361.00
129_G135_I1.8301.00
121_D124_K1.8061.00
27_E42_T1.7841.00
29_H79_Q1.7131.00
27_E81_R1.6601.00
13_A16_F1.6591.00
20_N53_T1.6191.00
76_T107_V1.5731.00
129_G133_K1.5381.00
19_V122_A1.5231.00
2_G108_V1.5231.00
5_S113_T1.5051.00
19_V126_I1.4721.00
5_S69_D1.4561.00
24_T83_V1.4501.00
20_N55_D1.4331.00
79_Q101_P1.3911.00
89_T133_K1.3831.00
3_T71_E1.3751.00
128_V134_Y1.3721.00
4_L28_V1.3301.00
30_P77_Y1.3091.00
7_S64_T1.2861.00
40_W44_T1.2541.00
41_V44_T1.2401.00
6_V116_L1.1991.00
66_L69_D1.1911.00
23_I54_V1.1781.00
96_S100_L1.1551.00
9_T117_V1.1501.00
7_S117_V1.1491.00
93_G96_S1.1441.00
88_L97_G1.1381.00
129_G132_G1.1231.00
90_V94_Q1.1181.00
27_E40_W1.1111.00
30_P73_P1.1061.00
95_Q98_L1.0981.00
74_A110_A1.0951.00
54_V65_T1.0951.00
39_G44_T1.0921.00
3_T69_D1.0811.00
92_S95_Q1.0781.00
127_V135_I1.0771.00
22_T51_P1.0721.00
18_S58_D1.0681.00
109_A114_T1.0641.00
7_S66_L1.0631.00
52_G65_T1.0341.00
28_V80_I1.0261.00
31_S76_T1.0211.00
96_S99_K1.0061.00
2_G74_A1.0031.00
92_S96_S0.9981.00
24_T84_L0.9911.00
5_S66_L0.9701.00
28_V72_L0.9621.00
21_V56_L0.9591.00
108_V114_T0.9581.00
91_P94_Q0.9331.00
29_H81_R0.9281.00
39_G43_L0.9081.00
82_L118_L0.8931.00
26_V82_L0.8831.00
9_T61_N0.8771.00
76_T103_N0.8691.00
104_F107_V0.8671.00
105_D109_A0.8651.00
14_D123_A0.8601.00
96_S102_S0.8531.00
16_F126_I0.8501.00
90_V96_S0.8491.00
57_L60_Q0.8451.00
88_L91_P0.8131.00
80_I118_L0.8051.00
28_V43_L0.7931.00
30_P33_G0.7921.00
128_V132_G0.7771.00
44_T50_T0.7701.00
128_V133_K0.7671.00
131_N135_I0.7601.00
23_I84_L0.7601.00
4_L116_L0.7601.00
87_P90_V0.7501.00
30_P41_V0.7161.00
3_T113_T0.7131.00
59_L65_T0.7111.00
6_V26_V0.7081.00
97_G100_L0.7071.00
30_P40_W0.7051.00
90_V97_G0.7041.00
108_V111_G0.7021.00
63_V67_L0.7001.00
57_L122_A0.6991.00
8_L54_V0.6961.00
91_P96_S0.6871.00
9_T64_T0.6871.00
9_T119_D0.6861.00
51_P85_G0.6841.00
91_P97_G0.6801.00
37_D42_T0.6781.00
122_A125_S0.6771.00
31_S78_T0.6751.00
64_T117_V0.6641.00
30_P39_G0.6621.00
94_Q97_G0.6591.00
92_S97_G0.6551.00
83_V97_G0.6541.00
49_S52_G0.6491.00
8_L23_I0.6481.00
89_T96_S0.6481.00
2_G77_Y0.6461.00
22_T52_G0.6411.00
16_F19_V0.6401.00
89_T92_S0.6371.00
20_N58_D0.6341.00
40_W81_R0.6341.00
130_G133_K0.6331.00
91_P101_P0.6261.00
94_Q99_K0.6241.00
30_P78_T0.6221.00
121_D125_S0.6201.00
107_V110_A0.6201.00
74_A109_A0.6191.00
16_F123_A0.6161.00
78_T105_D0.6141.00
13_A123_A0.6131.00
18_S22_T0.6121.00
96_S101_P0.6121.00
125_S136_L0.6111.00
38_G41_V0.6041.00
21_V120_F0.6021.00
67_L70_A0.6011.00
59_L63_V0.5961.00
73_P77_Y0.5951.00
65_T68_G0.5951.00
29_H39_G0.5951.00
4_L72_L0.5941.00
92_S99_K0.5831.00
72_L77_Y0.5831.00
28_V77_Y0.5811.00
126_I136_L0.5801.00
37_D41_V0.5801.00
10_D57_L0.5731.00
97_G101_P0.5681.00
23_I82_L0.5651.00
88_L126_I0.5651.00
13_A122_A0.5571.00
77_Y106_L0.5571.00
98_L101_P0.5571.00
29_H33_G0.5571.00
59_L64_T0.5551.00
102_S105_D0.5441.00
44_T49_S0.5421.00
122_A126_I0.5391.00
5_S68_G0.5341.00
80_I100_L0.5331.00
22_T86_S0.5301.00
17_D20_N0.5301.00
64_T68_G0.5261.00
19_V56_L0.5261.00
53_T85_G0.5251.00
91_P99_K0.5241.00
72_L108_V0.5221.00
73_P76_T0.5181.00
103_N106_L0.5131.00
2_G114_T0.5131.00
38_G43_L0.5121.00
126_I134_Y0.5071.00
119_D122_A0.5071.00
91_P95_Q0.5031.00
130_G135_I0.5021.00
133_K136_L0.5021.00
13_A126_I0.5011.00
59_L119_D0.5011.00
2_G5_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kkrA 2 0.8986 11.2 0.898 Contact Map
3rfzB 2 0.8696 5.6 0.911 Contact Map
4lm8A 1 0.8406 4.8 0.914 Contact Map
1ej6A 3 0.558 4 0.917 Contact Map
4jtmA 2 0.2899 3.9 0.918 Contact Map
2fauA 1 0.7391 3.6 0.919 Contact Map
3iylW 3 0.3333 3.4 0.92 Contact Map
3nqhA 2 0.7971 3.3 0.921 Contact Map
1o7dD 1 0.3913 3 0.922 Contact Map
2r51A 2 0.7319 2.5 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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