GREMLIN Database
Zn_Tnp_IS91 - Transposase zinc-binding domain
PFAM: PF14319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (108)
Sequences: 27913 (13846)
Seq/√Len: 1332.3
META: 0.981

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_R80_E3.2251.00
28_A59_N3.1021.00
101_A108_L3.0111.00
40_H55_N2.9461.00
31_R37_L2.6331.00
19_S22_Q2.5771.00
43_R50_E2.5431.00
95_H98_R2.5251.00
42_Y51_R2.2801.00
67_G71_A2.1181.00
41_V50_E2.1171.00
93_L101_A2.0501.00
41_V52_I2.0141.00
3_F26_L1.9401.00
27_R31_R1.9291.00
7_G26_L1.8561.00
26_L30_L1.8071.00
68_L72_R1.7831.00
23_R27_R1.7281.00
42_Y53_V1.6551.00
11_R23_R1.6511.00
31_R36_A1.6451.00
10_Y14_H1.6131.00
75_E78_Q1.5541.00
43_R48_G1.5301.00
24_K28_A1.4461.00
82_L86_Y1.4171.00
4_R30_L1.4021.00
25_V59_N1.3951.00
33_R64_K1.3951.00
7_G11_R1.3671.00
35_A54_Y1.3471.00
39_G52_I1.3241.00
102_L105_Q1.2371.00
34_T37_L1.2171.00
7_G30_L1.1781.00
69_A72_R1.1671.00
3_F29_I1.1451.00
62_C65_C1.1221.00
57_C62_C1.1201.00
39_G54_Y1.1181.00
99_P103_Q1.1081.00
25_V61_H1.0861.00
67_G70_R1.0771.00
44_C47_C1.0691.00
8_P12_A1.0591.00
33_R56_S1.0131.00
22_Q105_Q1.0071.00
10_Y18_L1.0001.00
72_R76_A0.9941.00
93_L108_L0.9821.00
98_R101_A0.9711.00
40_H53_V0.9691.00
7_G10_Y0.9651.00
11_R30_L0.9551.00
9_A12_A0.9531.00
52_I55_N0.9471.00
21_S25_V0.9451.00
104_N107_L0.9411.00
9_A13_R0.9341.00
18_L23_R0.9331.00
53_V64_K0.9301.00
96_E99_P0.9291.00
68_L71_A0.9261.00
20_P23_R0.9111.00
71_A75_E0.9021.00
3_F30_L0.8961.00
58_R69_A0.8761.00
74_L78_Q0.8551.00
20_P24_K0.8461.00
70_R74_L0.8411.00
76_A80_E0.8321.00
14_H18_L0.8311.00
66_Q70_R0.8301.00
34_T54_Y0.8301.00
57_C60_R0.8291.00
98_R102_L0.8111.00
101_A105_Q0.8111.00
11_R18_L0.8021.00
27_R30_L0.8021.00
2_I6_H0.8011.00
78_Q81_L0.7991.00
93_L98_R0.7871.00
76_A79_A0.7861.00
11_R26_L0.7841.00
66_Q69_A0.7791.00
6_H9_A0.7771.00
18_L22_Q0.7761.00
28_A31_R0.7741.00
105_Q109_Y0.7541.00
100_L104_N0.7481.00
42_Y49_H0.7401.00
57_C65_C0.7371.00
95_H99_P0.7321.00
43_R49_H0.7321.00
78_Q83_P0.7251.00
71_A78_Q0.7211.00
21_S59_N0.7161.00
11_R15_G0.7161.00
39_G55_N0.7001.00
71_A74_L0.6981.00
22_Q25_V0.6961.00
35_A52_I0.6931.00
93_L97_L0.6891.00
31_R34_T0.6821.00
75_E79_A0.6791.00
14_H17_R0.6791.00
100_L108_L0.6781.00
21_S24_K0.6741.00
56_S64_K0.6731.00
40_H52_I0.6641.00
61_H66_Q0.6591.00
35_A39_G0.6531.00
18_L26_L0.6531.00
29_I63_P0.6461.00
99_P102_L0.6431.00
98_R103_Q0.6411.00
8_P11_R0.6341.00
5_R8_P0.6211.00
101_A109_Y0.6201.00
70_R80_E0.6161.00
21_S105_Q0.6141.00
15_G23_R0.6141.00
6_H10_Y0.6071.00
4_R7_G0.6071.00
72_R75_E0.6051.00
8_P30_L0.5991.00
58_R66_Q0.5951.00
5_R9_A0.5891.00
76_A81_L0.5791.00
3_F10_Y0.5771.00
74_L77_R0.5771.00
15_G18_L0.5771.00
23_R30_L0.5761.00
12_A15_G0.5611.00
49_H52_I0.5591.00
7_G18_L0.5561.00
20_P27_R0.5551.00
7_G23_R0.5551.00
89_V92_T0.5511.00
33_R54_Y0.5481.00
23_R26_L0.5471.00
7_G14_H0.5451.00
4_R8_P0.5431.00
29_I34_T0.5401.00
3_F7_G0.5391.00
60_R65_C0.5361.00
55_N58_R0.5331.00
100_L103_Q0.5321.00
11_R14_H0.5291.00
19_S23_R0.5271.00
46_D49_H0.5221.00
25_V29_I0.5211.00
3_F6_H0.5191.00
95_H102_L0.5181.00
77_R82_L0.5181.00
48_G51_R0.5151.00
73_W76_A0.5061.00
80_E90_V0.5051.00
98_R105_Q0.5011.00
92_T95_H0.5011.00
54_Y64_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qiwP 1 0.3761 58.7 0.878 Contact Map
1gh9A 1 0.5413 58.7 0.878 Contact Map
1yuzA 2 0.578 49.3 0.884 Contact Map
4ce45 1 0.4404 49.2 0.884 Contact Map
4aybP 1 0.3853 45.8 0.886 Contact Map
1vq8Z 1 0.6697 44 0.888 Contact Map
3pwfA 4 0.6147 36.5 0.893 Contact Map
1lkoA 3 0.6606 30.8 0.897 Contact Map
2lcqA 1 0.6789 30.7 0.897 Contact Map
1vw4W 1 0.6972 26.5 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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