GREMLIN Database
DUF4381 - Domain of unknown function (DUF4381)
PFAM: PF14316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 145 (143)
Sequences: 6167 (5165)
Seq/√Len: 431.9
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_R47_Y3.5161.00
35_A39_W3.3571.00
36_L40_R3.2191.00
37_A41_R2.7521.00
59_R140_R2.6641.00
4_R7_H2.4051.00
54_E78_R2.3461.00
84_Y100_F2.3331.00
110_F113_G2.2671.00
118_L121_P2.2051.00
68_L136_L2.0901.00
64_D67_A2.0651.00
34_L38_L2.0521.00
38_L42_R1.9881.00
131_D134_A1.9591.00
128_D131_D1.9151.00
56_D140_R1.8681.00
72_L139_A1.8041.00
54_E57_R1.7921.00
41_R45_R1.7511.00
119_E123_R1.7441.00
79_V143_I1.7391.00
59_R136_L1.7301.00
80_A100_F1.7291.00
95_E99_A1.6561.00
33_L37_A1.6391.00
32_A36_L1.6131.00
17_P25_A1.6091.00
98_L102_D1.5851.00
102_D110_F1.5751.00
96_A99_A1.5601.00
73_S97_W1.5451.00
56_D59_R1.5421.00
81_L85_P1.4951.00
67_A71_A1.4891.00
18_A21_W1.4641.00
77_R93_T1.4511.00
81_L90_A1.4321.00
36_L39_W1.4131.00
100_F104_T1.4101.00
92_L100_F1.3941.00
73_S77_R1.3911.00
79_V83_A1.3821.00
19_P23_L1.3691.00
50_E54_E1.3681.00
94_G97_W1.3531.00
35_A38_L1.3281.00
19_P22_W1.3271.00
117_L121_P1.3011.00
99_A103_R1.2931.00
115_R119_E1.2891.00
58_L71_A1.2541.00
86_R90_A1.2401.00
39_W42_R1.2251.00
76_L139_A1.2231.00
68_L132_L1.2081.00
18_A22_W1.1931.00
36_L42_R1.1551.00
37_A40_R1.1441.00
140_R144_R1.1361.00
15_W18_A1.1241.00
86_R89_V1.1131.00
38_L41_R1.1091.00
73_S121_P1.0691.00
52_L140_R1.0661.00
58_L75_L1.0501.00
74_E78_R1.0471.00
73_S120_A1.0391.00
33_L36_L1.0321.00
69_L120_A1.0211.00
84_Y104_T1.0041.00
14_W17_P0.9981.00
52_L144_R0.9731.00
64_D68_L0.9721.00
21_W24_L0.9721.00
110_F114_A0.9481.00
48_R52_L0.9441.00
43_R46_R0.9381.00
136_L140_R0.9341.00
81_L89_V0.9291.00
133_E137_A0.9221.00
55_L75_L0.9191.00
108_P112_E0.9171.00
21_W25_A0.9121.00
13_S16_P0.9021.00
80_A89_V0.8851.00
31_L35_A0.8781.00
132_L136_L0.8761.00
77_R121_P0.8761.00
13_S17_P0.8721.00
32_A35_A0.8681.00
20_G23_L0.8631.00
102_D113_G0.8611.00
89_V92_L0.8411.00
109_E114_A0.8331.00
108_P111_S0.8321.00
98_L118_L0.8311.00
116_L119_E0.8291.00
72_L136_L0.8261.00
97_W100_F0.8161.00
33_L41_R0.8111.00
72_L135_L0.8111.00
59_R133_E0.8101.00
23_L26_A0.8091.00
39_W43_R0.8091.00
81_L86_R0.8021.00
55_L59_R0.7971.00
69_L135_L0.7961.00
66_A70_A0.7881.00
42_R45_R0.7831.00
15_W22_W0.7831.00
7_H77_R0.7791.00
35_A42_R0.7751.00
17_P22_W0.7581.00
51_A79_V0.7521.00
114_A138_L0.7491.00
109_E138_L0.7491.00
115_R118_L0.7481.00
20_G24_L0.7431.00
8_L11_P0.7411.00
37_A44_R0.7341.00
76_L101_L0.7321.00
79_V142_W0.7321.00
40_R43_R0.7301.00
58_L68_L0.7281.00
51_A54_E0.7251.00
116_L120_A0.7171.00
60_A63_A0.7141.00
16_P21_W0.7091.00
65_P132_L0.7041.00
78_R82_A0.7041.00
111_S114_A0.7031.00
105_G109_E0.7031.00
102_D111_S0.7031.00
52_L56_D0.7011.00
2_Q8_L0.6921.00
80_A142_W0.6911.00
35_A41_R0.6891.00
118_L122_Y0.6841.00
85_P88_E0.6841.00
107_T110_F0.6831.00
68_L71_A0.6811.00
77_R100_F0.6651.00
109_E113_G0.6641.00
54_E58_L0.6580.99
51_A143_I0.6510.99
47_Y83_A0.6500.99
116_L130_A0.6490.99
130_A133_E0.6460.99
109_E112_E0.6450.99
92_L97_W0.6400.99
120_A123_R0.6400.99
41_R44_R0.6370.99
68_L72_L0.6360.99
102_D112_E0.6310.99
110_F138_L0.6300.99
127_L130_A0.6290.99
107_T111_S0.6270.99
54_E71_A0.6260.99
22_W26_A0.6260.99
35_A40_R0.6250.99
5_D8_L0.6230.99
71_A74_E0.6170.99
12_V16_P0.6140.99
14_W18_A0.6110.99
62_A65_P0.6110.99
54_E75_L0.6040.99
15_W19_P0.6030.99
105_G138_L0.6000.99
84_Y89_V0.6000.99
140_R143_I0.5980.99
102_D138_L0.5970.99
115_R120_A0.5940.99
105_G108_P0.5940.99
127_L131_D0.5920.99
121_P124_P0.5920.99
55_L72_L0.5910.99
98_L115_R0.5900.99
137_A141_R0.5890.99
34_L37_A0.5860.99
37_A42_R0.5860.99
105_G141_R0.5820.99
51_A55_L0.5770.99
9_P12_V0.5750.99
65_P129_D0.5740.99
61_A65_P0.5710.99
73_S117_L0.5690.99
70_A121_P0.5590.98
8_L12_V0.5590.98
95_E115_R0.5560.98
93_T96_A0.5520.98
14_W21_W0.5500.98
4_R14_W0.5470.98
73_S76_L0.5450.98
33_L42_R0.5410.98
122_Y125_D0.5400.98
138_L141_R0.5360.98
132_L137_A0.5330.98
68_L73_S0.5320.98
70_A74_E0.5300.98
128_D132_L0.5280.98
52_L75_L0.5250.98
7_H22_W0.5240.98
99_A102_D0.5200.97
92_L98_L0.5170.97
102_D114_A0.5150.97
79_V84_Y0.5140.97
32_A39_W0.5120.97
13_S18_A0.5100.97
97_W101_L0.5080.97
42_R47_Y0.5070.97
109_E141_R0.5070.97
7_H11_P0.5010.97
26_A33_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.2897 48.4 0.881 Contact Map
3j6da 3 0 48.3 0.881 Contact Map
4tllB 2 0.2759 43.8 0.884 Contact Map
4p02B 1 0.3103 38.3 0.888 Contact Map
2m20A 2 0.4069 33.6 0.891 Contact Map
4v3iA 2 0.0828 33.3 0.891 Contact Map
4tllA 1 0.1655 32.3 0.892 Contact Map
2kluA 1 0.4552 27.4 0.896 Contact Map
5a2fA 1 0 26.5 0.897 Contact Map
2ks1B 1 0.3034 24.3 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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