GREMLIN Database
DUF4379 - Probable Zinc-ribbon domain
PFAM: PF14311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (54)
Sequences: 33270 (29105)
Seq/√Len: 3960.7
META: 0.946

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_E46_R2.9111.00
8_H38_E2.2961.00
16_T19_D2.1861.00
29_W40_E2.0861.00
15_L20_V1.9081.00
8_H31_K1.8911.00
42_S45_N1.8761.00
31_K38_E1.8271.00
37_H55_Y1.8071.00
28_V43_I1.7721.00
27_K40_E1.7561.00
23_G47_T1.5561.00
41_A45_N1.4961.00
11_K38_E1.4211.00
11_K29_W1.4111.00
39_W46_R1.3781.00
25_N44_S1.3581.00
24_S43_I1.3351.00
6_E33_P1.3191.00
27_K42_S1.3021.00
20_V43_I1.2901.00
7_W28_V1.2291.00
29_W38_E1.2211.00
15_L28_V1.1051.00
23_G44_S1.0721.00
41_A46_R1.0691.00
30_W46_R1.0591.00
8_H29_W1.0491.00
53_C56_C1.0051.00
4_A17_P0.9831.00
7_W17_P0.9721.00
39_W54_P0.9711.00
44_S48_R0.9491.00
15_L26_K0.9491.00
25_N42_S0.9221.00
45_N49_G0.9061.00
3_L47_T0.9041.00
45_N48_R0.8731.00
45_N50_N0.8471.00
8_H11_K0.8341.00
9_P17_P0.8301.00
7_W16_T0.7901.00
6_E39_W0.7901.00
20_V28_V0.7841.00
21_T24_S0.7661.00
20_V26_K0.7451.00
4_A16_T0.7271.00
15_L19_D0.7121.00
32_C56_C0.7101.00
22_P47_T0.7011.00
32_C37_H0.6961.00
34_K55_Y0.6871.00
34_K37_H0.6761.00
48_R51_G0.6711.00
33_P36_G0.6681.00
9_P31_K0.6641.00
24_S28_V0.6541.00
5_K33_P0.6491.00
41_A51_G0.6411.00
7_W12_N0.6311.00
46_R51_G0.6311.00
2_E5_K0.6281.00
12_N29_W0.6271.00
41_A50_N0.5921.00
30_W43_I0.5851.00
23_G48_R0.5791.00
30_W39_W0.5751.00
45_N51_G0.5741.00
36_G55_Y0.5671.00
1_P4_A0.5601.00
24_S42_S0.5491.00
7_W43_I0.5471.00
7_W20_V0.5381.00
27_K41_A0.5361.00
4_A7_W0.5301.00
33_P37_H0.5291.00
21_T25_N0.5241.00
27_K43_I0.5181.00
18_E22_P0.5141.00
10_T29_W0.5051.00
8_H12_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aybP 1 0.4464 70.5 0.713 Contact Map
4tpuA 3 0.9107 69 0.715 Contact Map
2lcqA 1 0.8393 68.7 0.716 Contact Map
1yuzA 2 0.875 63.6 0.726 Contact Map
3pwfA 4 0.8393 58.4 0.734 Contact Map
1lkoA 3 0.9107 55.9 0.739 Contact Map
5aunA 1 0.9286 54.2 0.741 Contact Map
1s24A 1 0.5536 54.2 0.741 Contact Map
2kdxA 1 0.8393 52.3 0.744 Contact Map
4qiwP 1 0.4107 50.8 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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